Expression of Epidermal Growth Factor Receptors in Human Breast Cancer: Mass Versus Ligand Binding Capacity

1995 ◽  
Vol 1 (2) ◽  
pp. 102-106 ◽  
Author(s):  
Slobodan Miseljic ◽  
Ai-Ru Yang ◽  
Vivian Jean M. Cline ◽  
James L. Wittliff
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Ligand Binding ◽  
Human Breast Cancer ◽  
Binding Capacity ◽  
Growth Factor Receptors ◽  
Epidermal Growth Factor Receptors ◽  
Human Breast ◽  
Epidermal Growth

Analysis of the genes for oestrogen and epidermal growth factor receptors in human breast cancer

The Breast ◽  
1996 ◽  
Vol 5 (5) ◽  
pp. 344-350 ◽  
Author(s):  
A.K. Sharma ◽  
D. Grimshaw ◽  
K. Horgan ◽  
G.T. Neades ◽  
J.M.W. Gee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Human Breast Cancer ◽  
Growth Factor Receptors ◽  
Epidermal Growth Factor Receptors ◽  
Human Breast ◽  
Epidermal Growth

Epidermal growth factor receptors in human breast cancer: a plea for standardisation of assay methodology

1992 ◽  
Vol 28 (2-3) ◽  
pp. 693-697 ◽  
Author(s):  
P.G. Koenders ◽  
C.B.M. Kienhuis ◽  
Th.J. Benraad ◽  
L.V.A.M. Beex ◽  
D. Faverly ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Human Breast Cancer ◽  
Growth Factor Receptors ◽  
Epidermal Growth Factor Receptors ◽  
Human Breast ◽  
Epidermal Growth

Epidermal growth factor receptors in human breast cancer

1984 ◽  
Vol 4 (3) ◽  
pp. 189-193 ◽  
Author(s):  
Rolando Pérez ◽  
María Pascual ◽  
Amparo Macías ◽  
Agustín Lage
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Human Breast Cancer ◽  
Growth Factor Receptors ◽  
Epidermal Growth Factor Receptors ◽  
Human Breast ◽  
Epidermal Growth

Steroidal regulation of oestradiol-17β dehydrogenase activity of the human breast cancer cell line MCF-7

1988 ◽  
Vol 118 (1) ◽  
pp. 149-154 ◽  
Author(s):  
E. F. Adams ◽  
N. G. Coldham ◽  
V. H. T. James
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Human Breast Cancer ◽  
Transforming Growth Factor ◽  
Cancer Cell Line ◽  
Human Breast Cancer Cell ◽  
Human Breast ◽  
Epidermal Growth ◽  
Mcf 7

ABSTRACT We have examined the direct effects of progestins, oestrogens, peptide hormones and growth factors on oestradiol-17β dehydrogenase (OE2DH) activity of cultures of the human breast cancer cell line MCF-7. Cells were cultured in the presence of steroid or peptide for 6 days, after which the number of cells was determined and cellular OE2DH activity assessed. Progesterone, 6α-methyl-17α-hydroxyprogesterone acetate, norethisterone and d(−)-norgestrel all profoundly inhibited cell mitosis and stimulated reductive (oestrone→oestradiol-17β) and oxidative (oestradiol-17β→oestrone) OE2DH activity. Both oestrone and oestradiol-17β directly stimulated reductive OE2DH activity, but had no effect on the oxidative direction. Oestradiol-17β stimulated cell growth only in phenolred free culture medium. Ovine prolactin, LH, epidermal growth factor and transforming growth factor did not alter OE2DH activity but small stimulatory effects on the growth of MCF-7 cells were exerted by prolactin and a combination of transforming growth factor with epidermal growth factor. It is concluded that these results may explain, at least in part, the alterations in mitotic activity and tissue oestradiol-17β levels observed in breast tissue during varying physiological and pathological conditions, such as during the menstrual cycle and in breast cancers. J. Endocr. (1988) 118, 149–154

Sign in / Sign up

Export Citation Format

Share Document