Inhibitory effect of azelastine, a potent antiallergic agent, on release of tumor necrosis factor-alpha from activated human peripheral blood mononuclear cells and U937 cells

1993 ◽  
Vol 2 (5) ◽  
pp. 231-235 ◽  
Author(s):  
Yoshiaki Hamamoto ◽  
Kou Nagai ◽  
Masahiko Muto ◽  
Chidori Asagami
2006 ◽  
Vol 74 (4) ◽  
pp. 2462-2467 ◽  
Author(s):  
Meguru Miyamoto ◽  
Kazuyuki Ishihara ◽  
Katsuji Okuda

ABSTRACT Dentilisin is a major surface protease and virulence factor of the bacterium Treponema denticola. In this study, we found that T. denticola reduced inflammatory cytokines, including interleukin-1β (IL-1β), IL-6, and tumor necrosis factor alpha, in peripheral blood mononuclear cells through degradation by dentilisin.


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