Stoichiometry of the Interleukin-6 High Affinity Receptor Complex

2006 ◽  
Vol 762 (1) ◽  
pp. 471-473 ◽  
Author(s):  
L. D. WARD ◽  
G. J. HOWLETT ◽  
A. HAMMACHER ◽  
R. L. MORITZ ◽  
R. J. SIMPSON
Keyword(s):  
Interleukin 6 ◽  
Receptor Complex ◽  
High Affinity ◽  
High Affinity Receptor ◽  
Affinity Receptor

Homodimeric Murine Interleukin-3 Agonists Indicate that Ligand Dimerization is Important for High-Affinity Receptor Complex Formation

1994 ◽  
Vol 10 (1) ◽  
pp. 17-27 ◽  
Author(s):  
Horst Müther ◽  
Klaus Kühlcke ◽  
André Gessner ◽  
Said Abdallah ◽  
Heinz Lother
Keyword(s):  
Complex Formation ◽  
Receptor Complex ◽  
Interleukin 3 ◽  
High Affinity ◽  
High Affinity Receptor ◽  
Affinity Receptor

Tumor Necrosis Factor (TNF)-Soluble High-Affinity Receptor Complex as a TNF Antagonist

2007 ◽  
Vol 322 (2) ◽  
pp. 822-828 ◽  
Author(s):  
Sean D. McKenna ◽  
Georg Feger ◽  
Christie Kelton ◽  
Meijia Yang ◽  
Vittoria Ardissone ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Receptor Complex ◽  
High Affinity ◽  
Tnf Antagonist ◽  
High Affinity Receptor ◽  
Affinity Receptor ◽  
Necrosis Factor

Assessing the role of Asp 194 in the transmembrane domains of the α-chain of the high-affinity receptor complex for immunoglobulin E in signal transduction

2010 ◽  
Vol 48 (1-3) ◽  
pp. 128-136 ◽  
Author(s):  
Amir Rashid ◽  
Marco W. Iodice ◽  
Kathleen M. Carroll ◽  
Jonathan E.M. Housden ◽  
Michael Hunter ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Immunoglobulin E ◽  
Transmembrane Domains ◽  
Receptor Complex ◽  
High Affinity ◽  
High Affinity Receptor ◽  
Affinity Receptor ◽  
Α Chain

scholarly journals Co-internalization of the p55 and p70 subunits of the high-affinity human interleukin 2 receptor. Evidence for a stable ternary receptor complex.

1988 ◽  
Vol 168 (5) ◽  
pp. 1923-1928 ◽  
Author(s):  
M R Fung ◽  
G Ju ◽  
W C Greene
Keyword(s):  
Binding Sites ◽  
Interleukin 2 ◽  
Affinity Binding ◽  
Receptor Complex ◽  
Homogeneous Population ◽  
High Affinity ◽  
Membrane Complex ◽  
High Affinity Receptor ◽  
Affinity Receptor ◽  
Receptor Assembly

The high-affinity IL-2-R complex is composed of at least two distinct IL-2-binding subunits, including p55 (Tac, IL-2-R alpha) and p70 (IL-2-R beta). Using a radiolabeled mAb specific for the p55 receptor subunit and cells expressing a homogeneous population of high-affinity binding sites, we demonstrate that p55 is co-internalized with p70 after IL-2 binding to the receptor complex. Endocytosis of p55 depends upon the presence of IL-2 in a form capable of effectively interacting with the p70 subunit. Whether IL-2 is required for high-affinity receptor assembly or triggering of the internalization of preassembled receptors remains unresolved. Together, these findings support the existence of a stable, high-affinity human IL-2-R membrane complex composed of at least the p55 and p70 receptor subunits and IL-2.

Sign in / Sign up

Export Citation Format

Share Document