TWO GENES CONTRIBUTE TO DIFFERENT EXTENTS TO THE HEME OXYGENASE ENZYME ACTIVITY MEASURED IN CULTURED HUMAN SKIN FIBROBLASTS AND KERATINOCYTES: IMPLICATIONS FOR PROTECTION AGAINST OXIDANT STRESS

1995 ◽  
Vol 61 (3) ◽  
pp. 285-291 ◽  
Author(s):  
Lee Ann Applegate ◽  
Alexandre Noël ◽  
Glenn Vile ◽  
Edgar Frenk ◽  
Rex M. Tyrrell
Keyword(s):  
Enzyme Activity ◽  
Human Skin ◽  
Heme Oxygenase ◽  
Oxidant Stress ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts

A role for Nrf2 in UVA-mediated heme oxygenase induction and protection from membrane damage in human skin fibroblasts

2010 ◽  
Author(s):  
Haibin Li ◽  
Linhao Li ◽  
Linhong Deng ◽  
Gurinder Singh ◽  
Rex M. Tyrrell ◽  
...  
Keyword(s):  
Human Skin ◽  
Heme Oxygenase ◽  
Membrane Damage ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts

Effect of zinc supplementation on resistance of cultured human skin fibroblasts toward oxidant stress

1993 ◽  
Vol 37 (2-3) ◽  
pp. 187-199 ◽  
Author(s):  
Marie-Jeanne Richard ◽  
Pascale Guiraud ◽  
Marie-Therese Leccia ◽  
Jean-Claude Beani ◽  
Alain Favier
Keyword(s):  
Human Skin ◽  
Zinc Supplementation ◽  
Oxidant Stress ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts

The role of Nrf2 in ultraviolet A mediated heme oxygenase 1 induction in human skin fibroblasts

2010 ◽  
Vol 9 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Julia L. Zhong ◽  
Gavin P. Edwards ◽  
Chintan Raval ◽  
Haibin Li ◽  
Rex M. Tyrrell
Keyword(s):  
Human Skin ◽  
Heme Oxygenase ◽  
Skin Fibroblasts ◽  
Heme Oxygenase 1 ◽  
Human Skin Fibroblasts ◽  
Ultraviolet A

scholarly journals The effect of β-carotene on the expression of interleukin-6 and heme oxygenase-1 in UV-irradiated human skin fibroblasts in vitro

FEBS Letters ◽  
2001 ◽  
Vol 509 (2) ◽  
pp. 186-190 ◽  
Author(s):  
Ute C. Obermüller-Jevic ◽  
Beate Schlegel ◽  
Andrea Flaccus ◽  
Hans Konrad Biesalski
Keyword(s):  
Human Skin ◽  
Heme Oxygenase ◽  
Interleukin 6 ◽  
Skin Fibroblasts ◽  
Heme Oxygenase 1 ◽  
Human Skin Fibroblasts ◽  
Β Carotene

Cholesterol-mediated regulation of HMG-CoA reductase in microsomes from human skin fibroblasts and rat liver

1990 ◽  
Vol 68 (3) ◽  
pp. 674-679 ◽  
Author(s):  
R. George ◽  
P. J. Davis ◽  
L. Luong ◽  
M. J. Poznansky
Keyword(s):  
Tissue Culture ◽  
Enzyme Activity ◽  
Human Skin ◽  
Rat Liver ◽  
Reductase Activity ◽  
Cholesterol Content ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Hmg Coa Reductase ◽  
Coa Reductase

3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase activity was determined in microsomes from human skin fibroblasts and rat liver that had been variously manipulated in vivo or in tissue culture to up- and down-regulate the enzyme. The cholesterol content of these microsomal preparations was then altered by depletion to or enrichment from either cholesterol-free or cholesterol-rich lipid vesicles. Microsomes from human skin fibroblasts responded to cholesterol depletion by increasing HMG-CoA reductase activity and by decreasing it in response to cholesterol enrichment. This was independent of the initial enzyme activity or the tissue culture conditions. Alterations in cholesterol content of rat liver microsomes in vitro failed to demonstrate any significant changes in HMG-CoA reductase activity whether the microsomes started with low enzyme activity (cholesterol-fed rats) or with high enzyme activity (cholestyramine-treated rats). The results are discussed in relation to previously published data and in respect to differences in the control of the human skin fibroblast and rat liver enzymes.Key words: cholesterol, HMG-CoA reductase, microsomes, fibroblasts, rat liver.

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