scholarly journals Antioxidant Status and Biomarkers of Oxidative Stress in Dogs with Lymphoma

2009 ◽  
Vol 23 (2) ◽  
pp. 311-316 ◽  
Author(s):  
J.L. Winter ◽  
L.G. Barber ◽  
L. Freeman ◽  
P.C. Griessmayr ◽  
P.E. Milbury ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Biomarkers Of Oxidative Stress

Antioxidant status and biomarkers of oxidative stress in cats with diabetes mellitus

2009 ◽  
Vol 93 (2) ◽  
pp. 145-145
Author(s):  
J. R. Smith ◽  
S. K. Cox ◽  
S. D. Lauten ◽  
R. C. Hill ◽  
J. W. Bartges ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Antioxidant Status ◽  
Biomarkers Of Oxidative Stress

Antioxidant status and biomarkers of oxidative stress in bovine leukemia virus-infected dairy cows

2011 ◽  
Vol 143 (1-2) ◽  
pp. 162-166 ◽  
Author(s):  
Fernando N. Souza ◽  
Andrea M. Monteiro ◽  
Priscilla R. dos Santos ◽  
Eduardo M. Ramos Sanchez ◽  
Maiara G. Blagitz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dairy Cows ◽  
Bovine Leukemia Virus ◽  
Antioxidant Status ◽  
Leukemia Virus ◽  
Biomarkers Of Oxidative Stress

scholarly journals Analyses of antioxidant status and nucleotide alterations in genes encoding antioxidant enzymes in patients with benign and malignant thyroid disorders

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3365 ◽  
Author(s):  
Nur Siti Fatimah Ramli ◽  
Sarni Mat Junit ◽  
Ng Khoon Leong ◽  
Nurhanani Razali ◽  
Jaime Jacqueline Jayapalan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Antioxidant Status ◽  
Antioxidant Activities ◽  
Control Group ◽  
Thyroid Disorders ◽  
Whole Exome ◽  
Genes Encoding ◽  
Gpx Activity ◽  
Biomarkers Of Oxidative Stress

Background Synthesis of thyroid hormones and regulation of their metabolism involve free radicals that may affect redox balance in the body. Thyroid disorders causing variations in the levels of thyroid hormones may alter cellular oxidative stress. The aim of this study was to measure the antioxidant activities and biomarkers of oxidative stress in serum and red blood cells (RBC) of patients with benign and malignant thyroid disorders and to investigate if changes in the antioxidant activities in these patients were linked to alterations in genes encoding the antioxidant enzymes. Methods Forty-one patients with thyroid disorders from University of Malaya Medical Centre were recruited. They were categorised into four groups: multinodular goitre (MNG) (n = 18), follicular thyroid adenoma (FTA) (n = 7), papillary thyroid cancer (PTC) (n = 10), and follicular thyroid cancer (FTC) (n = 6). Serum and RBC of patients were analysed for antioxidant activities, antioxidant enzymes, and biomarkers of oxidative stress. Alterations in genes encoding the antioxidant enzymes were analysed using whole exome sequencing and PCR–DNA sequencing. Results Patients with thyroid disorders had significantly higher serum superoxide dismutase (SOD) and catalase (CAT) activities compared to control, but had lower activities in RBC. There were no significant changes in serum glutathione peroxidase (GPx) activity. Meanwhile, GPx activity in RBC was reduced in PTC and FTC, compared to control and the respective benign groups. Antioxidant activities in serum were decreased in the thyroid disorder groups when compared to the control group. The levels of malondialdehyde (MDA) were elevated in the serum of FTA group when compared to controls, while in the RBC, only the MNG and PTC groups showed higher MDA equivalents than control. Serum reactive oxygen species (ROS) levels in PTC group of both serum and RBC were significantly higher than control group. Whole exome sequencing has resulted in identification of 49 single nucleotide polymorphisms (SNPs) in MNG and PTC patients and their genotypic and allelic frequencies were calculated. Analyses of the relationship between serum enzyme activities and the total SNPs identified in both groups revealed no correlation. Discussion Different forms of thyroid disorders influence the levels of antioxidant status in the serum and RBC of these patients, implying varying capability of preventing oxidative stress. A more comprehensive study with a larger target population should be done in order to further evaluate the relationships between antioxidant enzymes gene polymorphisms and thyroid disorders, as well as strengthening the minor evidences provided in literatures.

scholarly journals Biomarkers of Oxidative Stress and Antioxidant Status in Children Born Small for Gestational Age: Evidence of Lipid Peroxidation

2007 ◽  
Vol 62 (2) ◽  
pp. 204-208 ◽  
Author(s):  
Maria C P Franco ◽  
Elisa M Kawamoto ◽  
Renata Gorjão ◽  
Viviani M F Rastelli ◽  
Rui Curi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Antioxidant Status ◽  
Biomarkers Of Oxidative Stress

scholarly journals Role of Lipid Peroxidation Products, Plasma Total Antioxidant Status, and Cu-, Zn-Superoxide Dismutase Activity as Biomarkers of Oxidative Stress in Elderly Prediabetics

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Sylwia Dzięgielewska-Gęsiak ◽  
Ewa Wysocka ◽  
Sławomir Michalak ◽  
Ewa Nowakowska-Zajdel ◽  
Teresa Kokot ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Antioxidant Status ◽  
Plasma Lipids ◽  
Total Antioxidant Status ◽  
Oral Glucose ◽  
Elderly Persons ◽  
Arterial Blood ◽  
Total Antioxidant ◽  
Biomarkers Of Oxidative Stress

The relationship between hyperglycemia and oxidative stress in diabetes is well known, but the influence of metabolic disturbances recognized as prediabetes, in elderly patients especially, awaits for an explanation.Methods. 52 elderly persons (65 years old and older) with no acute or severe chronic disorders were assessed: waist circumference (WC), body mass index (BMI), percentage of body fat (FAT), and arterial blood pressure. During an oral glucose tolerance test (OGTT) fasting (0′) and 120-minute (120′) glycemia and insulinemia were determined, and type 2 diabetics (n=6) were excluded. Subjects were tested for glycated hemoglobin HbA1c, plasma lipids, total antioxidant status (TAS), thiobarbituric acid-reacting substances (TBARS), and activity of erythrocyte superoxide dismutase (SOD-1). According to OGTT results, patients were classified as normoglycemics, (NGT,n=18) and prediabetics, (PRE,n=28).Results. Both groups did not differ with their lipids, FAT, and TBARS. PRE group had higher WC (P<0.002) and BMI (P<0.002). Lower SOD-1 activity (P<0.04) and TAS status (P<0.04) were found in PRE versus NGT group.Significance. In elderly prediabetics, SOD-1 and TAS seem to reflect the first symptoms of oxidative stress, while TBARS are later biomarkers of oxidative stress.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

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