Pre‐procedure intravenous lidocaine administration on propofol consumption for endoscopic retrograde cholangiopancreatography: A prospective, randomized, double‐blind study

2020 ◽  
Author(s):  
Irem Ates ◽  
Muhammed Enes Aydin ◽  
Bulent Albayrak ◽  
Esra Disci ◽  
Elif Oral Ahiskalioglu ◽  
...  
Keyword(s):  
Endoscopic Retrograde Cholangiopancreatography ◽  
Blind Study ◽  
Double Blind Study ◽  
Intravenous Lidocaine ◽  
Endoscopic Retrograde ◽  
Double Blind ◽  
Lidocaine Administration

scholarly journals Doxapram as an additive to propofol sedation for endoscopic retrograde cholangiopancreatography: a placebo-controlled, randomized, double-blinded study

2020 ◽  
Vol 34 (12) ◽  
pp. 5477-5483 ◽  
Author(s):  
Jarno Jokelainen ◽  
Anna Belozerskikh ◽  
Harri Mustonen ◽  
Marianne Udd ◽  
Leena Kylänpää ◽  
...  
Keyword(s):  
Respiratory Depression ◽  
Endoscopic Retrograde Cholangiopancreatography ◽  
Significant Rise ◽  
Repeated Measurements ◽  
Double Blind Study ◽  
Continuous Variables ◽  
Endoscopic Retrograde ◽  
Double Blind ◽  
Clinical Trial Registration ◽  
Propofol Sedation

Abstract Background Endoscopic retrograde cholangiopancreatography (ERCP) requires moderate to deep sedation, usually with propofol. Adverse effects of propofol sedation are relatively common, such as respiratory and cardiovascular depression. This study was conducted to determine if doxapram, a respiratory stimulant, could be used to reduce the incidence of respiratory depression. Methods This is a single-center, prospective randomized double-blind study performed in the endoscopy unit of Helsinki University Central Hospital. 56 patients were randomized in a 1:1 ratio to either receive doxapram as an initial 1 mg/kg bolus and an infusion of 1 mg/kg/h (group DOX) or placebo (group P) during propofol sedation for ERCP. Main outcome measures were apneic episodes and hypoxemia (SpO2 < 90%). Mann–Whitney test for continuous variables and Fisher’s exact test for discrete variables were used and mixed effects modeling to take into account repeated measurements on the same subject and comparing both changes within a group as a function of time and between the groups. Results There were no statistically significant differences in apneic episodes (p = 0.18) or hypoxemia (p = 0.53) between the groups. There was a statistically significant rise in etCO2 levels in both groups, but the rise was smaller in group P. There was a statistically significant rise in Bispectral Index (p = 0.002) but not modified Observer’s Assessment of Agitation/Sedation (p = 0.21) in group P. There were no statistically significant differences in any other measured parameters. Conclusions Doxapram was not effective in reducing respiratory depression caused by deep propofol sedation during ERCP. Further studies are warranted using different sedation protocols and dosing regimens. Clinical trial registration ClinicalTrials.gov ID NCT02171910.

Postoperative analgesic efficacy of perioperative intravenous lidocaine infusion in patients undergoing septorhinoplasty: a prospective, randomized, double-blind study

2020 ◽  
Vol 277 (4) ◽  
pp. 1095-1100 ◽  
Author(s):  
İrem Ates ◽  
Muhammed Enes Aydin ◽  
Ali Ahiskalioglu ◽  
Elif Oral Ahiskalioglu ◽  
Zulkuf Kaya ◽  
...  
Keyword(s):  
Analgesic Efficacy ◽  
Blind Study ◽  
Double Blind Study ◽  
Intravenous Lidocaine ◽  
Double Blind

Intravenous lidocaine vs. NSAIDs for migraine attack in the ED: a prospective, randomized, double-blind study

2021 ◽  
Author(s):  
Sultan Tuna Akgol Gur ◽  
Elif Oral Ahiskalioglu ◽  
Muhammed Enes Aydin ◽  
Abdullah Osman Kocak ◽  
Pelin Aydin ◽  
...  
Keyword(s):  
Migraine Attack ◽  
Blind Study ◽  
Double Blind Study ◽  
Intravenous Lidocaine ◽  
Double Blind
Sign in / Sign up

Export Citation Format

Share Document