scholarly journals Pre-emptive analgesia and its supraspinal mechanisms: enhanced descending inhibition and decreased descending facilitation by dexmedetomidine

2016 ◽  
Vol 594 (7) ◽  
pp. 1875-1890 ◽  
Author(s):  
Hao-Jun You ◽  
Jing Lei ◽  
Ying Xiao ◽  
Gang Ye ◽  
Zhi-Hong Sun ◽  
...  
Keyword(s):  
Descending Inhibition ◽  
Descending Facilitation

scholarly journals Pain Treatment for Patients With Osteoarthritis and Central Sensitization

2013 ◽  
Vol 93 (6) ◽  
pp. 842-851 ◽  
Author(s):  
Enrique Lluch Girbés ◽  
Jo Nijs ◽  
Rafael Torres-Cueco ◽  
Carlos López Cubas
Keyword(s):  
Central Sensitization ◽  
Pain Treatment ◽  
Behavioral Therapy ◽  
Modern Society ◽  
Descending Inhibition ◽  
Osteoarthritis Pain ◽  
Descending Facilitation ◽  
Neuroscience Education ◽  
New Treatment ◽  
Central Pain Processing

Osteoarthritis is one of the most frequent, disabling, and costly pathologies of modern society. Among the main aims of osteoarthritis management are pain control and functional ability improvement. The exact cause of osteoarthritis pain remains unclear. In addition to the pathological changes in articular structures, changes in central pain processing or central sensitization appear to be involved in osteoarthritis pain. The latter calls for a broader approach to the management of patients with osteoarthritis. Yet, the scientific literature offers scant information addressing the treatment of central sensitization, specifically in patients with osteoarthritis. Interventions such as cognitive-behavioral therapy and neuroscience education potentially target cognitive-emotional sensitization (and descending facilitation), and centrally acting drugs and exercise therapy can improve endogenous analgesia (descending inhibition) in patients with osteoarthritis. Future studies should assess these new treatment avenues.

Behavioral analysis of anorexia produced by hindbrain injections of AMPA receptor antagonist NBQX in rats

2002 ◽  
Vol 282 (1) ◽  
pp. R147-R155 ◽  
Author(s):  
Huiyuan Zheng ◽  
Christiane Patterson ◽  
Hans-Rudolf Berthoud
Keyword(s):  
Nucleus Tractus Solitarius ◽  
Burst Size ◽  
Lick Rate ◽  
Ingestive Behavior ◽  
Receptor Subtypes ◽  
General Role ◽  
Motor Processing ◽  
Descending Facilitation ◽  
Response Measures ◽  
Integrative Process

The caudal brain stem integrates short-term feedback signals from the oral cavity and the food-handling abdominal viscera, as well as long-term homeostatic, cognitive, and emotional signals from the forebrain, to control ingestive behavior. Glutamate, acting on various receptor subtypes, plays a prominent role in this integrative process. Fourth ventricular injection of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)/kainate receptor blocker 1,2,3,4-tetrahydro-6-nitro-2,3-dioxobenzo[ f]quinoxaline-7-sulfonamide (NBQX, 0.5–5 nmol/3 μl) dose dependently suppressed intake of 15% sucrose in food-deprived and non-food-deprived rats compared with saline injection. Two consecutive paired NBQX injections (5 nmol) into the fourth ventricle did not produce conditioned taste aversion to saccharin, but LiCl did. Intraburst lick rate and lick efficiency were not affected, but burst size and number and initial lick rate were significantly decreased by NBQX. Local injection of NBQX (2 nmol) into and near the nucleus tractus solitarius also suppressed sucrose intake. These results suggest a general role for non- N-methyl-d-aspartate receptors in the transmission of positive (feedforward) signals, but do not identify the exact processing step involved, such as taste input, sensory-motor processing, or descending facilitation. More localized injections and response measures will be necessary.

Autotomy after nerve sections in the rat is influenced by tonic descending inhibition from locus coeruleus

1986 ◽  
Vol 67 (1) ◽  
pp. 82-86 ◽  
Author(s):  
Terence J. Coderre ◽  
Robert W. Grimes ◽  
Ronald Melzack
Keyword(s):  
Locus Coeruleus ◽  
Descending Inhibition

scholarly journals Experimental muscle pain impairs descending inhibition

Pain ◽  
2008 ◽  
Vol 140 (3) ◽  
pp. 465-471 ◽  
Author(s):  
Lars Arendt-Nielsen ◽  
Kathleen A. Sluka ◽  
Hong Ling Nie
Keyword(s):  
Muscle Pain ◽  
Descending Inhibition ◽  
Experimental Muscle Pain
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