Central and peripheral effects of the peptide ANF on renal function and blood pressure in hypertensive rats.

We have studied during 30 days the effect of a low dose of NG-nitro-L-arginine methyl ester (1 mg ·kg-1 ·day-1 in drinking water) in the presence of D- or L-arginine (1 mg ·kg-1 ·day-1 in drinking water) in comparison with D- or L-arginine alone on blood pressure and renal function in conscious uninephrectomized female spontaneously hypertensive rats. At the end of the study, there was a significant increase in systolic blood pressure in the NG-nitro-L-arginine methyl ester + D-arginine group (307 ± 6 mmHg (1 mmHg = 133.3 Pa), n = 14, p << 0.05) in comparison with NG-nitro-L-arginine methyl ester + L-arginine (281 ± 6 mmHg, n = 14), L-arginine (262 ± 5 mmHg, n = 13), and D-arginine (258 ± 7 mmHg, n = 12) groups. There were no changes in diuresis, proteinuria, or sodium and potassium excretion between differently treated animals during this study. These results suggest that in uninephrectomized female spontaneously hypertensive rats, after 1 month blockade of NO synthesis with a low dose of NG-nitro-L-arginine methyl ester, vasculature is under tonic control by NO and it is not correlated with renal dysfunction.Key words: Key words: NG -nitro-L-arginine methyl ester (L-NAME), kidney, hypertension, spontaneously hypertensive rats, renaldysfunction, uninephrectomy.

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Renin content and excretory function of the kidney in rats with experimental hypertension

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1962.202.4.795 ◽

1962 ◽

Vol 202 (4) ◽

pp. 795-799 ◽

Cited By ~ 19

Author(s):

H. Brunner ◽

P. A. Desaulles ◽

D. Regoli ◽

F. Gross

Keyword(s):

Blood Pressure ◽

Renal Function ◽

Renal Hypertension ◽

Experimental Hypertension ◽

Elevated Blood ◽

Hypertensive Rats ◽

Excretory Function ◽

Contralateral Kidney ◽

Ligation Of The Ureter ◽

Renin Content

To determine relationship between kidney renin content and excretory function, rats with renal hypertension induced by unilateral clamping of the renal artery were given an oral load of 3 ml of 0.9% saline/100 g body wt. Excretion of the saline load was accelerated in rats with renal hypertension as well as in animals with hypertension due to overdosage with cortexone and salt, provided that the loading experiment was made 3–4 weeks after hypertension was established, but not when animals had been hypertensive for 11–14 weeks. Renin concentration was markedly reduced in the unclamped kidney and also in the kidney of the rats overdosed with cortexone and salt. Excreting capacity of the clamped kidney was compared with that of the unclamped kidney, after removal or after functional elimination of the contralateral kidney, by ligation of the ureter, 3, 24, and 48 hr after the operation. In all experiments excretion of saline load by the unclamped kidney was more rapid than by the clamped kidney, but the highest values were reached in the presence of a functional clamped kidney. Only in rats with elevated blood pressure was the load more rapidly excreted than in normal rats, but hypertension alone cannot be the only factor responsible, the excretion not being accelerated in unilaterally nephrectomized hypertensive rats. Although these hint at a connection between the renin concentration and renal function the nature of this relationship remains uncertain.

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High-potassium diet attenuates salt-induced acceleration of hypertension in SHR

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1991.260.1.r21 ◽

1991 ◽

Vol 260 (1) ◽

pp. R21-R26 ◽

Cited By ~ 2

Author(s):

Y. Sato ◽

K. Ando ◽

E. Ogata ◽

T. Fujita

Keyword(s):

Blood Pressure ◽

Renal Function ◽

Spontaneously Hypertensive Rats ◽

Hypertensive Rats ◽

High Potassium ◽

Spontaneously Hypertensive ◽

Antihypertensive Action ◽

High K ◽

Wistar Kyoto ◽

Renal Vascular

We studied the effects of K supplementation (8% KCl) for 4 wk on blood pressure (BP), Na space, and renal hemodynamics in 5-wk-old, spontaneously hypertensive rats (SHR) or age-matched Wistar-Kyoto rats (WKY) eating normal-NaCl (0.66%) or high-NaCl (8%) diet. In WKY, high-Na and/or high-K diets had no effects on BP. In SHR, Na load accelerated the development of hypertension, whereas K supplementation did not affect BP of normal-Na SHR but attenuated the increase in BP with Na load. Correspondingly, Na load in SHR significantly increased renal vascular resistance (RVR), and K supplementation attenuated the increased RVR of Na-loaded SHR. Moreover, Na space of SHR was increased compared with that of WKY, and although Na load did not affect Na space, K supplementation tended to decrease Na space in SHR. These results indicate that 9-wk-old SHR is relatively volume-expanded compared with age-matched WKY, and K supplementation could improve the lowered slope of the pressure-Na excretion relationship in SHR, resulting in maintenance of Na balance. Thus the data suggest that changes in RVR, which might be intimately related to renal function for Na excretion, contribute to both salt sensitivity of SHR and antihypertensive action of K supplementation in Na-loaded SHR.

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Differential regulation of blood pressure and renal function by renal at1 receptors in normotensive and spontaneously hypertensive rats

American Journal of Hypertension ◽

10.1016/j.amjhyper.2004.03.247 ◽

2004 ◽

Vol 17 (5) ◽

pp. S95-S96

Author(s):

M YONEDA

Keyword(s):

Blood Pressure ◽

Renal Function ◽

Spontaneously Hypertensive Rats ◽

Differential Regulation ◽

Hypertensive Rats ◽

At1 Receptors ◽

Spontaneously Hypertensive ◽

Regulation Of Blood Pressure

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Antihypertensive and renal effects of cilazapril and their reversal by angiotensin in renovascular hypertensive rats

Clinical Science ◽

10.1042/cs0740365 ◽

1988 ◽

Vol 74 (4) ◽

pp. 365-372 ◽

Cited By ~ 6

Author(s):

Yu-An Ding ◽

Shin-Tsu Chang ◽

Shyh-Ming Shieh ◽

Wann-Chu Huang

Keyword(s):

Blood Pressure ◽

Renal Function ◽

Angiotensin Ii ◽

Enzyme Inhibitor ◽

Fractional Excretion ◽

Hypotensive Effect ◽

Hypertensive Rats ◽

Renal Effects ◽

Angiotensin Iii ◽

Excretion Rates

1. The antihypertensive and renal effects of cilazapril, a new angiotensin converting enzyme inhibitor, were evaluated in both two-kidney, one-clip Goldblatt hypertensive rats (n = 11) and normotensive rats (n = 6). 2. Intravenous infusion of cilazapril (1 mg/kg followed by 25 μg min−1 kg−1) caused significant reductions of blood pressure from 163 ± 3 to 122 ± 4 mmHg and from 157 ± 2 to 113 ± 3 mmHg in two separate groups of hypertensive rats and from 124 ± 1 to 105 ± 2 mmHg in normotensive rats. The hypotensive effect in terms of absolute value or percentage change was greater in hypertensive rats than in normotensive rats (41 ± 6 vs 20 ± 3 mmHg or 25 ± 4% vs 16 ± 2%, respectively). 3. Cilazapril increased glomerular filtration rate, urine flow, and absolute and fractional excretion rates of sodium and potassium in the non-clipped kidney of hypertensive rats. In contrast, the clipped kidney exhibited a depressed renal function during cilazapril infusion. 4. In normotensive rats, the hypotensive and enhanced renal function responses to cilazapril were much less than those of the non-clipped kidney of hypertensive rats. 5. Superimposed administration of either angiotensin II or angiotensin III during cilazapril infusion completely reversed the blood pressure and bilateral renal responses of cilazapril in both hypertensive and normotensive rats. 6. These results indicate that cilazapril reduces arterial pressure and enhances renal excretion mainly via inhibition of angiotensin II and angiotensin III formation.

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Comparative Evaluation of Aloe vera and Diclofenac on Body Weight, Blood Pressure and Renal Function of Hypertensive Rats

Proceedings of Shaikh Zayed Medical Complex Lahore - October to December ◽

10.47489/p000s351z7821-6mc ◽

2021 ◽

Vol 35 (1) ◽

pp. 39-44

Author(s):

Nadeem Yaqoob

Keyword(s):

Blood Pressure ◽

Renal Function ◽

Body Weight ◽

Systolic Blood Pressure ◽

Aloe Vera ◽

Treated Group ◽

Control Group ◽

Hypertensive Rats ◽

Aloe Vera Gel ◽

Group B

Introduction: NSAIDs are known to cause salt and water retention leading to hypertension and renal impairment. Aloe vera gel has been used in medicinal preparations for decades. Limited data is available regarding effect of Aloe vera on renal function. There is a need to search this aspect of Aloe vera, to use it judiciously. Aims & Objectives: To estimate and compare the effects of Aloe vera and diclofenac on systolic blood pressure and renal functions of hypertensive rats. Place and duration of study: This study was conducted at Post Graduate Medical Institute Lahore, Sargodha Medical College, Sargodha and Department of Pharmacy, University of Sargodha for the period of three months. Material & Methods: Male Sprague Dawley rats (n=24) were divided into four groups; Group A (Normal control), Group B (Hypertensive control), Group C (Aloe vera treated) and Group D (Diclofenac treated). Hypertension was induced in groups B, C and D by 20% sucrose diet in 8 weeks. After induction of hypertension, distilled water, dried Aloe vera gel 400 mg/kg and diclofenac 12 mg/kg were given orally to group B, C and D respectively for 2 weeks as a single morning dose. Body weight and systolic blood pressure were measured weekly, while serum creatinine, creatinine clearance and urinary proteins were estimated and compared at 0, 8 and 10 weeks. Data was analyzed using SPSS 23 and p value of ?0.05 was considered significant. Results: Diclofenac decreased body weight of rats non-significantly and increased systolic blood pressure significantly (p< 0.03) whereas Aloe vera increased body weight significantly (p<0.012) and had no significant effect on systolic blood pressure. Diclofenac treated group showed deterioration of renal function as compared to Aloe vera treated group numerically. Conclusion: Aloe vera may be safer anti-inflammatory agent than diclofenac for treatment of chronic inflammatory conditions if the patient also has hypertension or renal disease.

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