Interrelationships among Blood Pressure, Renal Function, Thyroid Activity and Renal Thyroid Depressing Factor in Renal Hypertensive Rats

We have studied during 30 days the effect of a low dose of NG-nitro-L-arginine methyl ester (1 mg ·kg-1 ·day-1 in drinking water) in the presence of D- or L-arginine (1 mg ·kg-1 ·day-1 in drinking water) in comparison with D- or L-arginine alone on blood pressure and renal function in conscious uninephrectomized female spontaneously hypertensive rats. At the end of the study, there was a significant increase in systolic blood pressure in the NG-nitro-L-arginine methyl ester + D-arginine group (307 ± 6 mmHg (1 mmHg = 133.3 Pa), n = 14, p << 0.05) in comparison with NG-nitro-L-arginine methyl ester + L-arginine (281 ± 6 mmHg, n = 14), L-arginine (262 ± 5 mmHg, n = 13), and D-arginine (258 ± 7 mmHg, n = 12) groups. There were no changes in diuresis, proteinuria, or sodium and potassium excretion between differently treated animals during this study. These results suggest that in uninephrectomized female spontaneously hypertensive rats, after 1 month blockade of NO synthesis with a low dose of NG-nitro-L-arginine methyl ester, vasculature is under tonic control by NO and it is not correlated with renal dysfunction.Key words: Key words: NG -nitro-L-arginine methyl ester (L-NAME), kidney, hypertension, spontaneously hypertensive rats, renaldysfunction, uninephrectomy.

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Renin content and excretory function of the kidney in rats with experimental hypertension

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1962.202.4.795 ◽

1962 ◽

Vol 202 (4) ◽

pp. 795-799 ◽

Cited By ~ 19

Author(s):

H. Brunner ◽

P. A. Desaulles ◽

D. Regoli ◽

F. Gross

Keyword(s):

Blood Pressure ◽

Renal Function ◽

Renal Hypertension ◽

Experimental Hypertension ◽

Elevated Blood ◽

Hypertensive Rats ◽

Excretory Function ◽

Contralateral Kidney ◽

Ligation Of The Ureter ◽

Renin Content

To determine relationship between kidney renin content and excretory function, rats with renal hypertension induced by unilateral clamping of the renal artery were given an oral load of 3 ml of 0.9% saline/100 g body wt. Excretion of the saline load was accelerated in rats with renal hypertension as well as in animals with hypertension due to overdosage with cortexone and salt, provided that the loading experiment was made 3–4 weeks after hypertension was established, but not when animals had been hypertensive for 11–14 weeks. Renin concentration was markedly reduced in the unclamped kidney and also in the kidney of the rats overdosed with cortexone and salt. Excreting capacity of the clamped kidney was compared with that of the unclamped kidney, after removal or after functional elimination of the contralateral kidney, by ligation of the ureter, 3, 24, and 48 hr after the operation. In all experiments excretion of saline load by the unclamped kidney was more rapid than by the clamped kidney, but the highest values were reached in the presence of a functional clamped kidney. Only in rats with elevated blood pressure was the load more rapidly excreted than in normal rats, but hypertension alone cannot be the only factor responsible, the excretion not being accelerated in unilaterally nephrectomized hypertensive rats. Although these hint at a connection between the renin concentration and renal function the nature of this relationship remains uncertain.

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Time course of the enhanced blood pressure response to reinduction of renal artery stenosis in unclipped renal hypertensive rats

Pflügers Archiv - European Journal of Physiology ◽

10.1007/bf00582148 ◽

1979 ◽

Vol 380 (2) ◽

pp. 133-137 ◽

Cited By ~ 4

Author(s):

Rob G. M. ten Berg ◽

Wybren de Jong

Keyword(s):

Blood Pressure ◽

Renal Artery ◽

Renal Artery Stenosis ◽

Time Course ◽

Blood Pressure Response ◽

Pressure Response ◽

Artery Stenosis ◽

Hypertensive Rats ◽

Renal Hypertensive Rats

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High-potassium diet attenuates salt-induced acceleration of hypertension in SHR

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1991.260.1.r21 ◽

1991 ◽

Vol 260 (1) ◽

pp. R21-R26 ◽

Cited By ~ 2

Author(s):

Y. Sato ◽

K. Ando ◽

E. Ogata ◽

T. Fujita

Keyword(s):

Blood Pressure ◽

Renal Function ◽

Spontaneously Hypertensive Rats ◽

Hypertensive Rats ◽

High Potassium ◽

Spontaneously Hypertensive ◽

Antihypertensive Action ◽

High K ◽

Wistar Kyoto ◽

Renal Vascular

We studied the effects of K supplementation (8% KCl) for 4 wk on blood pressure (BP), Na space, and renal hemodynamics in 5-wk-old, spontaneously hypertensive rats (SHR) or age-matched Wistar-Kyoto rats (WKY) eating normal-NaCl (0.66%) or high-NaCl (8%) diet. In WKY, high-Na and/or high-K diets had no effects on BP. In SHR, Na load accelerated the development of hypertension, whereas K supplementation did not affect BP of normal-Na SHR but attenuated the increase in BP with Na load. Correspondingly, Na load in SHR significantly increased renal vascular resistance (RVR), and K supplementation attenuated the increased RVR of Na-loaded SHR. Moreover, Na space of SHR was increased compared with that of WKY, and although Na load did not affect Na space, K supplementation tended to decrease Na space in SHR. These results indicate that 9-wk-old SHR is relatively volume-expanded compared with age-matched WKY, and K supplementation could improve the lowered slope of the pressure-Na excretion relationship in SHR, resulting in maintenance of Na balance. Thus the data suggest that changes in RVR, which might be intimately related to renal function for Na excretion, contribute to both salt sensitivity of SHR and antihypertensive action of K supplementation in Na-loaded SHR.

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Quantitative assay and disappearance rate of circulating renin

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1964.206.6.1361 ◽

1964 ◽

Vol 206 (6) ◽

pp. 1361-1364 ◽

Cited By ~ 34

Author(s):

G. Schaechtelin ◽

D. Regoli ◽

F. Gross

Keyword(s):

Blood Pressure ◽

Blood Pressure Response ◽

Pressure Response ◽

Pressure Increase ◽

Disappearance Rate ◽

Hypertensive Rats ◽

Contralateral Kidney ◽

Blood Pressure Increase ◽

Hypertensive Animal ◽

Renal Hypertensive Rats

In isovolemic cross-circulation experiments, a nephrectomized donor rat, into which various doses of hog renin were injected, was connected to a nephrectomized indicator rat. The blood pressure increase thus produced in the indicator rat was compared with the blood pressure response obtained during cross circulation using either intact normotensive or renal hypertensive rats as donor animals. An exponential dose-response relationship was found between hog renin injected into a nephrectomized donor and the blood pressure increase of the indicator rat. Using the cross-circulation technique, the disappearance rate of endogenous reninlike material in the blood of donor animals and of exogenous renin injected into nephrectomized donor animals was examined. If an intact normotensive animal or a unilaterally nephrectomized hypertensive animal is totally nephrectomized, reninlike material disappears from the blood within 1 hr. In renal hypertensive rats with an untouched contralateral kidney which have a higher concentration of reninlike material in the blood, it takes about twice the normal time until reninlike material disappears from the blood after nephrectomy. The increased and prolonged blood pressure response of the nephrectomized animal to renin is not connected with a prolonged persistence of renin in the blood.

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Anti-hypertension Effects of Traditional Chinese Medicine Ju-Ling-Tang on Renal Hypertensive Rats

The American Journal of Chinese Medicine ◽

10.1142/s0192415x05003545 ◽

2005 ◽

Vol 33 (06) ◽

pp. 913-921 ◽

Cited By ~ 14

Author(s):

Hung-Che Shih ◽

Tzu-Hsin Lee ◽

Shu-Chen Chen ◽

Chien-Ying Li ◽

Takeshi Shibuya

Keyword(s):

Blood Pressure ◽

Animal Model ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Renal Hypertension ◽

Tube Feeding ◽

Glomerular Sclerosis ◽

Hypertensive Rats ◽

Artery Ligation ◽

Renal Hypertensive Rats

This research investigated the anti-hypertension effect of the traditional Chinese medicine (TCM) Ju-Ling-Tang (JLT) on an animal model of hypertension induced by unilateral renal artery ligation. In the study of anti-hypertension effects, 60 minutes after oral administration with NG tube feeding of 240 mg/kg JLT, a significant decrease in blood pressure ( p < 0.05) was observed and sustained till 120 minutes. In the group given 50 mg/kg α-methyldopa orally, the effect was obvious 90 minutes after medication ( p < 0.01), and lasted until 240 minutes. In terms of organ pathology, a significant reduction in the extent of induced glomerular sclerosis was observed in rats given 240 mg/kg JLT compared with the control. From these results, we infer that JLT has a beneficial anti-hypertensive effect on renal hypertension.

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