scholarly journals Atrial natriuretic peptide modulation of albumin clearance and contrast agent permeability in mouse skeletal muscle and skin: role in regulation of plasma volume

2010 ◽  
Vol 588 (2) ◽  
pp. 325-339 ◽  
Author(s):  
Fitz-Roy E. Curry ◽  
Cecilie Brekke Rygh ◽  
Tine Karlsen ◽  
Helge Wiig ◽  
Roger H. Adamson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Atrial Natriuretic Peptide ◽  
Contrast Agent ◽  
Natriuretic Peptide ◽  
Plasma Volume ◽  
Mouse Skeletal Muscle ◽  
Albumin Clearance ◽  
Atrial Natriuretic

Atrial Natriuretic Peptide as a Regulator of Transvascular Fluid Balance

Physiology ◽  
1996 ◽  
Vol 11 (3) ◽  
pp. 138-143 ◽  
Author(s):  
EM Renkin ◽  
VL Tucker
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Volume ◽  
Fluid Balance ◽  
Interstitial Fluid ◽  
Fluid Volume ◽  
Interstitial Fluid Volume ◽  
Atrial Natriuretic

Unlike other natriuretics, which act via the kidneys to reduce interstitial fluid volume with little change in plasma volume, atrial natriuretic peptide has important extrarenal actions that enable it to reduce plasma volume preferentially.

Atrial Natriuretic Peptide and Response to Changing Plasma Volume in Diabetic Nephropathy

Diabetes ◽  
1991 ◽  
Vol 40 (7) ◽  
pp. 893-901 ◽  
Author(s):  
J. S. Lieberman ◽  
L. Parra ◽  
L. Newton ◽  
J. D. Scandling ◽  
N. Loon ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Volume ◽  
Atrial Natriuretic

scholarly journals Interaction of platelet-activating factor, spleen and atrial natriuretic peptide in plasma volume regulation during endotoxaemia in rats

1998 ◽  
Vol 512 (1) ◽  
pp. 227-234 ◽  
Author(s):  
Xiao-Wu Qu ◽  
Ranna A. Rozenfeld ◽  
Wei Huang ◽  
Susan E. Crawford ◽  
F. Gonzalez-Crussi ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Volume ◽  
Volume Regulation ◽  
Platelet Activating Factor ◽  
Atrial Natriuretic

scholarly journals Acute alveolar hypoxia increases blood-to-tissue albumin transport: role of atrial natriuretic peptide

1997 ◽  
Vol 82 (1) ◽  
pp. 111-117 ◽  
Author(s):  
T. S. E. Albert ◽  
V. L. Tucker ◽  
E. M. Renkin
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Volume ◽  
Acute Hypoxia ◽  
Whole Body ◽  
Abdominal Muscles ◽  
Rat Serum ◽  
Alveolar Hypoxia ◽  
Atrial Natriuretic

Albert, T. S. E., V. L. Tucker, and E. M. Renkin. Acute alveolar hypoxia increases blood-to-tissue albumin transport: role of atrial natriuretic peptide. J. Appl. Physiol. 82(1): 111–117, 1997.—Plasma immunoreactive atrial natriuretic peptide (irANP) and blood-to-tissue clearance of 131I-labeled rat serum albumin (CRSA) were examined in anesthetized rats during hypoxic ventilation ( n = 5–7/group). Hypoxia (10 min) increased irANP from 211 ± 29 (room air) to 229 ± 28 (15% O2, not significant), 911 ± 205 (10% O2), and 4,374 ± 961 pg/ml (8% O2), respectively. Graded increases in CRSA were significant at 8% O2 in fat (3.6-fold), ileum (2.2-fold), abdominal muscles (2.0-fold), kidney (1.8-fold), and jejunum (1.4-fold). CRSA was decreased in back skin and testes; heart, brain, and lungs were unaffected. The increases in CRSAwere related to irANP and not to arterial[Formula: see text]. Circulating plasma volume was negatively correlated with whole body CRSA. Graded increases in extravascular water content (EVW) were found in the kidney, left heart, and cerebrum and were positively related to CRSA in the kidney. EVW decreased in gastrointestinal tissues; the magnitude was inversely related to CRSA. We conclude that ANP-induced protein extravasation contributes to plasma volume contraction during acute hypoxia.

Relationship between atrial natriuretic peptide and plasma volume during graded exercise with water immersion

1995 ◽  
Vol 78 (1) ◽  
pp. 217-224 ◽  
Author(s):  
K. Nagashima ◽  
H. Nose ◽  
T. Yoshida ◽  
T. Kawabata ◽  
Y. Oda ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Volume ◽  
Water Immersion ◽  
Peak Oxygen Consumption ◽  
Time Control ◽  
Peak Vo2 ◽  
The Difference ◽  
The Relationship ◽  
Atrial Natriuretic

To assess the relationship between atrial natriuretic peptide (ANP) and the reduction in plasma volume (PV) during exercise, we measured changes in PV and ANP in seven male volunteers during treadmill exercise in air (AE) and with water immersion (WE) together with time control studies of rest in air and in water. Blood samples were collected from a catheter in the antecubital vein at exercise intensities of 32, 49, 65, and 78% of peak oxygen consumption (VO2). Plasma ANP in AE increased significantly from the resting value [15 +/- 1 (SE) pg/ml] only at 78% of peak VO2 (29 +/- 5 pg/ml), whereas ANP in WE increased significantly at exercise levels of > 49% of peak VO2 and reached 68 +/- 9 pg/ml at 78% of peak VO2. Although PV in AE and WE decreased significantly with VO2 of > 49% of peak VO2 (P < 0.01), the decrease from the resting value in WE was significantly greater than that in AE of > 65% of peak VO2 (P < 0.01) and the decreases at 78% of peak VO2 were -9.7 +/- 0.8 and -6.1 +/- 1.7%, respectively. The difference in the decrease in PV between AE and WE at corresponding VO2 correlated strongly with that in the increase in ANP (r = -0.97; P < 0.01). These results are consistent with the hypothesis that ANP may be involved in the fluid shift from the intra- to extravascular space during exercise.

Atrial natriuretic peptide in normal and pre-eclamptic human pregnancy

1997 ◽  
Vol 9 (4) ◽  
pp. 209-221 ◽  
Author(s):  
DW Irons ◽  
PH Baylis ◽  
JM Davison
Keyword(s):  
Renal Function ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Volume ◽  
Renal Plasma Flow ◽  
Contributory Factor ◽  
Plasma Volume Expansion ◽  
Human Pregnancy ◽  
Venous Dilatation ◽  
Atrial Natriuretic

Successful human pregnancy is associated with striking physiological changes. Plasma volume increases early in the first trimester, attaining maximal expansion near term, when the increment above non-pregnant values is about 1.5 L (50–60%), and is a contributory factor in maintaining organ perfusion in the presence of arteriolar and venous dilatation. Effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) increase to values 50–70% above non-pregnant levels by term. There are also gestational alterations in osmoregulation as well as in the renal handling of sodium, potassium and glucose, coincident with altered tubular function. Plasma volume expansion is significantly related to fetal growth and pregnancies complicated by intrauterine growth retardation and pre-eclampsia are associated with reduced plasma volume and impaired renal function. Elucidation of factors involved in volume homeostasis and renal function in pregnancy is therefore of clinical as well as physiological importance. Atrial natriuretic peptide (ANP) causes vasodilatation, natriuresis and inhibition of the renin-angiotensin system and is clearly an important factor in volume homeostasis and renal function.

Response to atrial natriuretic peptide in dogs with hypovolemic acute pancreatitis

1989 ◽  
Vol 256 (2) ◽  
pp. F211-F217
Author(s):  
M. Levy ◽  
P. Cernacek
Keyword(s):  
Blood Pressure ◽  
Acute Pancreatitis ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Volume ◽  
Sodium Excretion ◽  
Fractional Excretion ◽  
Fractional Excretion Of Sodium ◽  
Acute Renal Insufficiency ◽  
Atrial Natriuretic

The ability of atrial natriuretic peptide (ANP) to preserve renal function in dogs with hypovolemic acute renal insufficiency was tested in anesthetized dogs 4 h after the induction of acute pancreatitis. Plasma volume had decreased by 21.5% and glomerular filtration rate (GFR) by 43.2%. Blood pressure had declined by 30 mmHg. ANP was given intravenously at 50 and 150 ng.kg-1.min-1. With the lower dose, blood pressure (BP), GFR, and clearance of p-aminohippuric acid (CPAH) did not change but urine flow (V) and sodium excretion (UNaV) increased. With the higher dose, BP declined by 25 mmHg, GFR declined, but V and UNaV still increased. When plasma volume was maintained with 4% colloid during the progression of pancreatitis and ANP 50 ng.kg-1.min-1 given, BP declined, GFR did not change, and there was a magnified increment in V and UNaV. The administration of glucagon (5 micrograms/min iv) to dogs with hypovolemic pancreatitis caused BP to decline by 17 mmHg. Despite a major increment in GFR, fractional excretion of sodium increased only slightly, compared with that obtained with ANP. We conclude that glucagon preserves GFR more effectively than ANP in hypovolemia, but ANP is more effective in protecting urinary water and sodium excretion.

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