scholarly journals Acute alveolar hypoxia increases blood-to-tissue albumin transport: role of atrial natriuretic peptide

1997 ◽  
Vol 82 (1) ◽  
pp. 111-117 ◽  
Author(s):  
T. S. E. Albert ◽  
V. L. Tucker ◽  
E. M. Renkin
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Volume ◽  
Acute Hypoxia ◽  
Whole Body ◽  
Abdominal Muscles ◽  
Rat Serum ◽  
Alveolar Hypoxia ◽  
Atrial Natriuretic

Albert, T. S. E., V. L. Tucker, and E. M. Renkin. Acute alveolar hypoxia increases blood-to-tissue albumin transport: role of atrial natriuretic peptide. J. Appl. Physiol. 82(1): 111–117, 1997.—Plasma immunoreactive atrial natriuretic peptide (irANP) and blood-to-tissue clearance of 131I-labeled rat serum albumin (CRSA) were examined in anesthetized rats during hypoxic ventilation ( n = 5–7/group). Hypoxia (10 min) increased irANP from 211 ± 29 (room air) to 229 ± 28 (15% O2, not significant), 911 ± 205 (10% O2), and 4,374 ± 961 pg/ml (8% O2), respectively. Graded increases in CRSA were significant at 8% O2 in fat (3.6-fold), ileum (2.2-fold), abdominal muscles (2.0-fold), kidney (1.8-fold), and jejunum (1.4-fold). CRSA was decreased in back skin and testes; heart, brain, and lungs were unaffected. The increases in CRSAwere related to irANP and not to arterial[Formula: see text]. Circulating plasma volume was negatively correlated with whole body CRSA. Graded increases in extravascular water content (EVW) were found in the kidney, left heart, and cerebrum and were positively related to CRSA in the kidney. EVW decreased in gastrointestinal tissues; the magnitude was inversely related to CRSA. We conclude that ANP-induced protein extravasation contributes to plasma volume contraction during acute hypoxia.

Atrial natriuretic peptide levels and plasma volume contraction in acute alveolar hypoxia

1997 ◽  
Vol 82 (1) ◽  
pp. 102-110 ◽  
Author(s):  
T. S. E. Albert ◽  
V. L. Tucker ◽  
E. M. Renkin
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Protein ◽  
Plasma Volume ◽  
Urine Output ◽  
Arterial Oxygen ◽  
Volume Contraction ◽  
Alveolar Hypoxia ◽  
Oxygen Tensions ◽  
Atrial Natriuretic

Albert, T. S. E., V. L. Tucker, and E. M. Renkin.Atrial natriuretic peptide levels and plasma volume contraction in acute alveolar hypoxia. J. Appl. Physiol. 82(1): 102–110, 1997.—Arterial oxygen tensions ([Formula: see text]), atrial natriuretic peptide (ANP) concentrations, and circulating plasma volumes (PV) were measured in anesthetized rats ventilated with room air or 15, 10, or 8% O2( n = 5–7). After 10 min of ventilation, [Formula: see text] values were 80 ± 3, 46 ± 1, 32 ± 1, and 35 ± 1 Torr and plasma immunoreactive ANP (irANP) levels were 211 ± 29, 229 ± 28, 911 ± 205, and 4,374 ± 961 pg/ml, respectively. At[Formula: see text] ≤40 Torr, irANP responses were more closely related to inspired O2( P = 0.014) than to[Formula: see text] ( P= 0.168). PV was 36.3 ± 0.5 μl/g in controls but 8.5 and 9.9% lower ( P ≤ 0.05) for 10 and 8% O2, respectively. Proportional increases in hematocrit were observed in animals with reduced PV; however, plasma protein concentrations were not different from control. Between 10 and 50 min of hypoxia, small increases (+40%) in irANP occurred in 15% O2; however, there was no further change in PV, hematocrit, plasma protein, or irANP levels in the lower O2groups. Urine output tended to fall during hypoxia but was not significantly different among groups. These findings are compatible with a role for ANP in mediating PV contraction during acute alveolar hypoxia.

Role of insulin and atrial natriuretic peptide in sodium retention in insulin-treated IDDM patients during isotonic volume expansion

Diabetes ◽  
1990 ◽  
Vol 39 (3) ◽  
pp. 289-298 ◽  
Author(s):  
R. Trevisan ◽  
P. Fioretto ◽  
A. Semplicini ◽  
G. Opocher ◽  
F. Mantero ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Volume Expansion ◽  
Sodium Retention ◽  
Atrial Natriuretic

Atrial Natriuretic Peptide as a Regulator of Transvascular Fluid Balance

Physiology ◽  
1996 ◽  
Vol 11 (3) ◽  
pp. 138-143 ◽  
Author(s):  
EM Renkin ◽  
VL Tucker
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Volume ◽  
Fluid Balance ◽  
Interstitial Fluid ◽  
Fluid Volume ◽  
Interstitial Fluid Volume ◽  
Atrial Natriuretic

Unlike other natriuretics, which act via the kidneys to reduce interstitial fluid volume with little change in plasma volume, atrial natriuretic peptide has important extrarenal actions that enable it to reduce plasma volume preferentially.

Role of NPR-C natriuretic receptor in nitric oxide system activation induced by atrial natriuretic peptide

2006 ◽  
Vol 135 (1-2) ◽  
pp. 63-68 ◽  
Author(s):  
María Ángeles Costa ◽  
Rosana Elesgaray ◽  
Ana María Balaszczuk ◽  
Cristina Arranz
Keyword(s):  
Nitric Oxide ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Oxide System ◽  
System Activation ◽  
Nitric Oxide System ◽  
Atrial Natriuretic

scholarly journals A Possible Physiological Role of Atrial Natriuretic Peptide in Body Fluid Volume Regulation

1988 ◽  
Vol 13 ◽  
pp. S62-S68
Author(s):  
Yasunobu Hirata ◽  
Masao Ishii ◽  
Kazushige Fukui ◽  
Hiroshi Hayakawa ◽  
Shin-ichiro Namba ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Volume Regulation ◽  
Body Fluid ◽  
Physiological Role ◽  
Fluid Volume ◽  
Body Fluid Volume ◽  
Fluid Volume Regulation ◽  
Atrial Natriuretic

Contribution of the kidney to metabolic clearance of atrial natriuretic peptide

1988 ◽  
Vol 255 (6) ◽  
pp. E934-E941
Author(s):  
R. L. Woods
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Renal Clearance ◽  
Natriuretic Peptide ◽  
Clearance Rate ◽  
The Body ◽  
Whole Body ◽  
Metabolic Clearance ◽  
Peripheral Tissues ◽  
Urine Production ◽  
Atrial Natriuretic

To quantify the role of the kidney in whole body metabolic clearance rate (MCR) from plasma of atrial natriuretic peptide (ANP), synthetic alpha-human ANP-(1-28) was infused at 200 ng/min to steady-state conditions in chronically instrumented one-kidney conscious dogs. Clearances were measured in dogs with a normally filtering kidney and they were also measured after the glomerular filtration rate (GFR) was reduced to close to zero by acutely inflating a cuff around the renal artery (RAC), which resulted in minimal urine production and renal blood flow reduction to 59% of the resting level. In normal dogs, MCR was 1,090 +/- 134 ml/min with renal clearance rate (RCR) contributing only 13.9%. After RAC, MCR fell to 864 +/- 151 ml/min, due in part to a fall in RCR (-41.5 +/- 12.9 ml/min), but mostly due to a fall in "rest of the body" (total renal) clearance of ANP. The reduced GFR accounted for virtually all the fall in RCR. Normal plasma ANP half-life was 59.6 +/- 7.9 s. In conclusion, MCR of ANP was very high, approaching the cardiac output, suggesting that most of ANP is cleared in one circulation through peripheral tissues. GFR contributed significantly to RCR (approximately 30%) but the contribution of the kidney to whole body MCR was small relative to rest of the body clearance of ANP.

Sign in / Sign up

Export Citation Format

Share Document