Study on Liquid Lithium Target System for Boron Neutron Capture Therapy (BNCT)

2010 ◽  
Author(s):  
Minoru Takahashi ◽  
Tooru Kobayashi ◽  
Masashi Nakatsuka ◽  
Teddy Ardiansyah ◽  
Martin Kulha´nek ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
High Velocity ◽  
Liquid Lithium ◽  
Target System ◽  
Neutron Capture Therapy ◽  
Flow Loop ◽  
Boron Neutron Capture ◽  
The Stability ◽  
Plane Jet

The concept of the liquid lithium target system for the boron neutron capture therapy (BNCT) using an accelerator was formulated. A lithium flow loop was designed and fabricated for development of lithium jet nozzles that provide a stable lithium plane jet. A water flow loop was designed, fabricated and used for development of lithium jet nozzles. Experiment of water plane jet was conducted to investigate the stability of high velocity plane jets. A large amount of droplets were entrained from the jet surface when the jet was unstable. The jet was observed by being illuminated with a stroboscope. It was found that a stable plane jet was realized by using a nozzle with the gap of 0.5mm and the length of 70mm. It was concluded that a fully developed flow without inlet disturbances at the outlet of the nozzle was required for the stability of the high velocity plane jet.

Study on Stability of Liquid Jet for Liquid Lithium Target of Boron Neutron Capture Therapy (BNCT)

2016 ◽  
Author(s):  
Yuki Maehara ◽  
Masatoshi Kondo ◽  
Minoru Takahashi
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Jet Flow ◽  
Water Jet ◽  
Liquid Lithium ◽  
Neutron Capture Therapy ◽  
Nozzle Outlet ◽  
Boron Neutron Capture ◽  
Surface Disturbance ◽  
The Stability

For the development of the liquid lithium (Li) jet target system for the boron neutron capture therapy (BNCT), the stability of the Li jet is important. The purpose of the present study is to investigate the characteristics of the disturbances and the droplet formation of a water jet flow at high velocity. The experimental studies for a water jet flow were performed to simulate the liquid Li jet flow. The nozzles in the experiment had a rectangular flow channel with the gap of 0.5 mm and the length of 10 mm and 70 mm. The water flow velocities in these nozzles were 5 m/s, 10 m/s or 15 m/s. The stability of the water jet flow was investigated by the observation of the surface disturbance using a high speed video camera. The formation of water droplet from the water jet flow was detected, and the characteristics of the droplet formation were analyzed using Phase Doppler Anemometry (PDA). Then, the surface disturbance of the jet flow was characterized by the characteristics of the droplet generation. In the experiment with 10mm length of nozzle, a lot of droplets are generated from the jet surface and the surface is considered to be unstable. On the other hand the smooth jet surface and the stable jet are made near nozzle outlet. In the experiment with 70mm length of nozzle, few droplets are generated from the surface of the jet and the surface of the jet is very smooth especially for the place near nozzle outlet. It was concluded that the droplet generation from the surface of the water jet was promoted by the distortion of the jet surface. Also the surfaces of the jet flow made by the nozzle having the length of 70 mm was smoother than those in the tests with the nozzle having the length of 10 mm. The large eddy in the flow must be dumped before the nozzle outlet because the turbulence was fully developed in the nozzle.

High-power liquid-lithium target prototype for accelerator-based boron neutron capture therapy

2011 ◽  
Vol 69 (12) ◽  
pp. 1654-1656 ◽  
Author(s):  
S. Halfon ◽  
M. Paul ◽  
A. Arenshtam ◽  
D. Berkovits ◽  
M. Bisyakoev ◽  
...  
Keyword(s):  
High Power ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Liquid Lithium ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Lithium Target

Development of beryllium-based neutron target system with three-layer structure for accelerator-based neutron source for boron neutron capture therapy

2015 ◽  
Vol 106 ◽  
pp. 78-83 ◽  
Author(s):  
Hiroaki Kumada ◽  
Toshikazu Kurihara ◽  
Masakazu Yoshioka ◽  
Hitoshi Kobayashi ◽  
Hiroshi Matsumoto ◽  
...  
Keyword(s):  
Neutron Source ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Layer Structure ◽  
Target System ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

scholarly journals HGG-05. REGRESSION OF RECURRENT GLIOBLASTOMA AFTER BORON NEUTRON CAPTURE THERAPY AND CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY IN A CHILD

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii345-iii345
Author(s):  
Hsin-Hung Chen ◽  
Yi-Wei Chen
Keyword(s):  
T Cells ◽  
T Cell ◽  
Chimeric Antigen Receptor ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Antigen Receptor ◽  
Neutron Capture Therapy ◽  
T Cell Therapy ◽  
Boron Neutron Capture ◽  
Car T

Abstract A 6 y/o girl with recurrent multifocal glioblastoma received 3 times of boron neutron capture therapy (BNCT) and chimeric antigen receptor (CAR)–engineered T cells targeting the tumor-associated antigen HER2. Multiple infusions of CAR T cells were administered over 30 days through intraventricular delivery routes. It was not associated with any toxic effects of grade 3 or higher. After BNCT and CAR T-cell treatment, regression of all existing intracranial lesions were observed, along with corresponding increases in levels of cytokines and immune cells in the cerebrospinal fluid, but new lesions recurred soon after the treatment. This clinical response continued for 14 months after the initiation of first recurrence.

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