Design and Fabrication of a Mock Circulatory System for Reliability Tests on Aortic Heart Valves

Author(s):  
Dhruv Singh ◽  
Abhishek Singhal

The dynamic stress analysis and response of artificial heart valves — specifically the aortic valve is impending following the increasing number of artificial valve failures. This calls for the development of a mock circulatory system in order to establish clearly the parameters associated with the circulatory system in the heart and their effects on the robustness of a prosthetic implant.

1999 ◽  
Vol 82 (S 01) ◽  
pp. 130-135 ◽  
Author(s):  
Freek W. A. Verheugt

SummaryInsertion of a mechanical artificial heart valve is an absolute indication for the use of lifelong oral anticoagulation, irrespective the presence or absence of atrial fibrillation. Depending on the type and position of the artificial valve the optimal International Normalized Ratio (INR) for these patients is between 2.5 and 4.5, although more prospective studies on the optimal range of oral anticoagulation are necessary. Addition of low dose antiplatelet therapy may further decrease the rate of thromboembolism, but also here more studies are needed. Patients with a bioprosthesis need only oral anticoagulation for the first three months following surgery in the absence of an indication for anticoagulation for other conditions.Atrial fibrillation is often seen in patients with artificial heart valves. Stroke prevention can be instituted by the mandatory oral anticoagulant therapy. The presence of atrial fibrillation and the use of oral anticoagulation prior to heart valve surgery support the indication for the insertion of a mechanical artificial heart valve. However, relative contraindications to oral anticoagulation and the presence of sinus rhythm may favor the use of a bioprosthesis.


2021 ◽  
Vol 1094 (1) ◽  
pp. 012120
Author(s):  
Hussein Togun ◽  
Ali Abdul Hussain ◽  
Saja Ahmed ◽  
Iman Abdul hussain ◽  
Huda Shaker

1997 ◽  
Vol 20 (1) ◽  
pp. 37-42 ◽  
Author(s):  
K. Mabuchi ◽  
T. Chinzei ◽  
Y. Abe ◽  
K. Imanishi ◽  
T. Isoyama ◽  
...  

An electrochemical sensor system to allow real-time measurement and feedback of catecholamine concentrations was developed for use in the control of artificial hearts. Electrochemical analyses were carried out using a carbon fiber working electrode, an Ag-AgCI reference electrode, and a potentiostat. The operating parameters of the pneumatically-driven artificial heart system were altered in accordance with the algorithm for changes in the catecholamine concentration. The minimum detectable concentrations of both adrenaline and noradrenaline in a mock circulatory system using a phosphate-buffered solution were approximately 1-2 ng/ml (10-8 mol/L). An artificial heart control system utilizing this set-up performed satisfactorily without delay, although sensor sensitivity decreased when placed in goat plasma instead of a phosphate-buffered solution, due to the adsorption of various substances such as plasma proteins onto the electrodes. This study demonstrated the future feasibility of a feedback control system for artificial hearts using catecholamine concentrations.


1977 ◽  
Vol 19 (6) ◽  
pp. 1537-1544
Author(s):  
E.I. Semenenko ◽  
A.I. Ivanov ◽  
M.A. Markelov ◽  
N.B. Dobrova ◽  
Ye.V. Smurova ◽  
...  

1976 ◽  
Vol 61 (4) ◽  
pp. 504-512 ◽  
Author(s):  
Carlos Ibarra-Perez ◽  
Noel Arevalo-Toledo ◽  
Octavio Alvarez-De La Cadena ◽  
Luis Noriega-Guerra

The Lancet ◽  
1962 ◽  
Vol 280 (7266) ◽  
pp. 1171 ◽  
Author(s):  
R.W.M. Frater

2010 ◽  
Vol 143 (4) ◽  
pp. 331
Author(s):  
H. Aupperle ◽  
F. Gruenwald ◽  
P. Kiefer ◽  
J. Kempfert ◽  
T. Walther ◽  
...  

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