Use of a Catecholamine Sensor in the Control of an Artificial Heart System

1997 ◽  
Vol 20 (1) ◽  
pp. 37-42 ◽  
Author(s):  
K. Mabuchi ◽  
T. Chinzei ◽  
Y. Abe ◽  
K. Imanishi ◽  
T. Isoyama ◽  
...  

An electrochemical sensor system to allow real-time measurement and feedback of catecholamine concentrations was developed for use in the control of artificial hearts. Electrochemical analyses were carried out using a carbon fiber working electrode, an Ag-AgCI reference electrode, and a potentiostat. The operating parameters of the pneumatically-driven artificial heart system were altered in accordance with the algorithm for changes in the catecholamine concentration. The minimum detectable concentrations of both adrenaline and noradrenaline in a mock circulatory system using a phosphate-buffered solution were approximately 1-2 ng/ml (10-8 mol/L). An artificial heart control system utilizing this set-up performed satisfactorily without delay, although sensor sensitivity decreased when placed in goat plasma instead of a phosphate-buffered solution, due to the adsorption of various substances such as plasma proteins onto the electrodes. This study demonstrated the future feasibility of a feedback control system for artificial hearts using catecholamine concentrations.

1977 ◽  
Vol 99 (4) ◽  
pp. 184-188 ◽  
Author(s):  
K. M. High ◽  
J. A. Brighton ◽  
A. D. Brickman ◽  
W. S. Pierce

A mathematical model is developed for calculating the pressures and flows in an artificial heart, its pneumatic drive unit, and a mock circulatory system. The system is divided into convenient subsystems to facilitate the analysis, and each subsystem is then analyzed separately. The set of independent equations developed is solved on a computer and corresponding experimental tests are made on the actual system. A comparison of the experimental and computer results shows good agreement for the mean flow rate through the pump and also for several instantaneous pressures and flow rates in the system.


ASAIO Journal ◽  
2006 ◽  
Vol 52 (2) ◽  
pp. 42A
Author(s):  
Hassan A Khalil ◽  
Ralph W Metcalfe ◽  
O H Frazier ◽  
Kamuran A Kadipasaoglu

2010 ◽  
Vol 29 (5) ◽  
pp. 568-573 ◽  
Author(s):  
Hassan A. Khalil ◽  
Daniel T. Kerr ◽  
Mark A. Schusterman ◽  
William E. Cohn ◽  
O.H. Frazier ◽  
...  

Author(s):  
Dhruv Singh ◽  
Abhishek Singhal

The dynamic stress analysis and response of artificial heart valves — specifically the aortic valve is impending following the increasing number of artificial valve failures. This calls for the development of a mock circulatory system in order to establish clearly the parameters associated with the circulatory system in the heart and their effects on the robustness of a prosthetic implant.


ASAIO Journal ◽  
2008 ◽  
Vol 54 (3) ◽  
pp. 249-255 ◽  
Author(s):  
Hassan A. Khalil ◽  
Daniel T. Kerr ◽  
Matthew A. Franchek ◽  
Ralph W. Metcalfe ◽  
Robert J. Benkowski ◽  
...  

2007 ◽  
Vol 129 (11) ◽  
pp. 1422-1427 ◽  
Author(s):  
Takayuki Suzuki ◽  
Romain Prunières ◽  
Hironori Horiguchi ◽  
Tomonori Tsukiya ◽  
Yoshiyuki Taenaka ◽  
...  

In centrifugal pumps for artificial hearts, a magnetic drive with lightly loaded journal bearing system is often used. In such a system, the rigidity of the bearing is small and the impeller usually rotates over the critical speed. In such cases, the rotordynamic fluid forces play an important role for shaft vibration. In the present study, the characteristics of the rotordynamic fluid forces on the impeller were examined. The rotordynamic fluid forces were measured in the cases with/without the whirling motion. It was found that the rotordynamic forces become destabilizing in a wide range of positive whirl. The effect of leakage flow was also examined.


2014 ◽  
Vol 945-949 ◽  
pp. 2568-2572
Author(s):  
Si Yuan Wang ◽  
Guang Sheng Ren ◽  
Pan Nie

The test rig for hydro-pneumatic converter used in straddle type monorail vehicles was researched, and its electro-pneumatic proportional control system was set up and simulated based on AMESim/Simulink. Compared fuzzy-PID (Proportion Integral Derivative) controller with PID controller through fuzzy logic tool box in Simulink, the results indicate that, this electro-pneumatic proportional control system can meet design requirements better, and fuzzy-PID controller has higher accuracy and stability than PID controller.


2010 ◽  
Vol 455 ◽  
pp. 206-210
Author(s):  
Jun Li Liu ◽  
Yan Yan Yan ◽  
G.Q. He

It discusses the reasons of the data transmission time delay and packets loss based on the theory of net data transmission. Aimed to the question of the time delay of data transmission and packets loss, the control system models are set up to analyze their influence to the performance of the control system. Based on the synchronous control model analysis with wireless data transmission, a method to control the system is reached with the state prediction when the communication error or data loss appears. It can control constantly when communication errors appear, and also it can get the most error period by numerical analysis.


2013 ◽  
Vol 842 ◽  
pp. 541-545
Author(s):  
Yun Guo ◽  
Zhi Qiang Huang ◽  
Shun Xin Yang

Natural gas heaters are widely used in gas-fired power plants to meet the combustion needs and to improve the combustion efficiency. For the control features and technical requirements of the natural gas heater, the computer automatic control system for natural gas heater has been designed,and realizes the temperature and liquid level real time measurement and control. The system increases significantly the control accuracy of natural gas temperature, eliminates potential unsafety and improves production efficiency.


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