Live imaging of mammalian embryonic development

SPIE Newsroom ◽  
2011 ◽  
Author(s):  
Kirill Larin ◽  
Irina V. Larina ◽  
Mary E. Dickinson
Keyword(s):  
Embryonic Development ◽  
Live Imaging ◽  
Mammalian Embryonic Development

scholarly journals Live imaging YAP signaling in vivo with fusion reporter mice

2021 ◽  
Author(s):  
Bin Gu ◽  
Brian Bradshaw ◽  
Min Zhu ◽  
Yu Sun ◽  
Sevan Hopyan ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Cell Polarity ◽  
Near Infrared ◽  
Kinase Activity ◽  
Live Imaging ◽  
Mouse Line ◽  
Reporter Mouse ◽  
Reporter Mice ◽  
Mammalian Embryonic Development

YAP protein is a critical regulator of mammalian embryonic development. By generating a near-infrared fusion YAP reporter mouse line, we have achieved high-resolution live imaging of YAP localization during mouse embryonic development. We have validated the reporter by demonstrating its predicted responses to blocking Lats kinase activity or blocking cell polarity. The YAP fusion reporter mice and imaging methods will open new opportunities for understanding dynamic YAP signaling in vivo in many different situations.

scholarly journals Features of DNA Repair in the Early Stages of Mammalian Embryonic Development

Genes ◽  
2020 ◽  
Vol 11 (10) ◽  
pp. 1138 ◽  
Author(s):  
Evgenia V. Khokhlova ◽  
Zoia S. Fesenko ◽  
Julia V. Sopova ◽  
Elena I. Leonova
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Embryonic Development ◽  
Somatic Cells ◽  
Genomic Integrity ◽  
Embryonic Period ◽  
Early Stages ◽  
Mammalian Embryos ◽  
Disparate Data ◽  
Mammalian Embryonic Development

Cell repair machinery is responsible for protecting the genome from endogenous and exogenous effects that induce DNA damage. Mutations that occur in somatic cells lead to dysfunction in certain tissues or organs, while a violation of genomic integrity during the embryonic period often leads to death. A mammalian embryo’s ability to respond to damaged DNA and repair it, as well as its sensitivity to specific lesions, is still not well understood. In this review, we combine disparate data on repair processes in the early stages of preimplantation development in mammalian embryos.

The Role of Autophagy in Early Mammalian Embryonic Development

2013 ◽  
Vol 30 (3) ◽  
pp. 86-94 ◽  
Author(s):  
Satoshi Tsukamoto ◽  
Atsushi Yamamoto
Keyword(s):  
Embryonic Development ◽  
Mammalian Embryonic Development
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