SU-F-R-45: The Prognostic Value of Radiotherapy Based On the Changes of Texture Features Between Pre-Treatment and Post-Treatment FDG PET Image for NSCLC Patients

2016 ◽  
Vol 43 (6Part7) ◽  
pp. 3383-3383
Author(s):  
C Ma ◽  
Y Yin
Keyword(s):  
Fdg Pet ◽  
Prognostic Value ◽  
Texture Features ◽  
Post Treatment ◽  
Pre Treatment ◽  
Nsclc Patients

scholarly journals 18F-FDG-PET/CT in radiation therapy-induced parotid gland inflammation

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Alaa Mouminah ◽  
Austin J. Borja ◽  
Emily C. Hancin ◽  
Yu Cheng Chang ◽  
Thomas J. Werner ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Post Treatment ◽  
Parotid Glands ◽  
Positron Emission ◽  
Pet Ct ◽  
Average Maximum ◽  
Pre Treatment ◽  
Fdg Pet Ct

Abstract Background 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) is used in the clinical management of oncologic and inflammatory pathologies. It may have utility in detecting radiotherapy (RT)-induced damage of oral tissues. Thus, the aim of the present study was to use FDG-PET/CT to evaluate parotid gland inflammation following RT in patients with head and neck cancer (HNC). Methods This retrospective study included patients with HNC treated with photon, proton, or combined photon/proton RT, in addition to chemotherapy. All patients received FDG-PET/CT imaging pre-treatment and 3 months post-treatment. The average mean standardized uptake value (Avg SUVmean) and the average maximum standardized uptake value (Avg SUVmax) of the left and right parotid glands were determined by global assessment of FDG activity using OsiriX MD software. A two-tailed paired t test was used to compare Avg SUVmean and Avg SUVmax pre- and post-RT. Results Forty-seven HNC patients were included in the study. Parotid gland Avg SUVmean was significantly higher at 3 months post-treatment than pre-treatment (p < 0.05) in patients treated with photon RT, but no significant differences were found between pre- and post-treatment Avg SUVmean in patients treated with proton RT or combined photon/proton RT. Conclusion Our results suggest that photon RT may cause radiation-induced inflammation of the parotid gland, and that proton RT, which distributes less off-target radiation, is a safer treatment alternative.

scholarly journals Hepatocellular Carcinoma Drug-Eluting Bead Transarterial Chemoembolization (DEB-TACE): Outcome Analysis Using a Model Based On Pre-Treatment CT Texture Features

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 956
Author(s):  
Marcello Andrea Tipaldi ◽  
Edoardo Ronconi ◽  
Elena Lucertini ◽  
Miltiadis Krokidis ◽  
Marta Zerunian ◽  
...  
Keyword(s):  
Texture Analysis ◽  
Clinical Data ◽  
Transarterial Chemoembolization ◽  
Prognostic Value ◽  
Texture Features ◽  
Response To Therapy ◽  
Survival Prediction ◽  
Ct Examination ◽  
Drug Eluting ◽  
Pre Treatment

(1) Introduction and Aim: The aim of this study is to investigate the prognostic value, in terms of response and survival, of CT-based radiomics features for patients with HCC undergoing drug-eluting beads transarterial chemoembolization (DEB-TACE). (2) Materials and Methods: Pre-treatment CT examinations of 50 patients with HCC, treated with DEB-TACE were manually segmented to obtain the tumor volumetric region of interest, extracting radiomics features with TexRAD. Response to therapy evaluation was performed basing on post-procedural CT examination compared to pre-procedural CT, using modified RECIST criteria for HCC. The prognostic value of texture analysis was evaluated, investigating the correlation between radiomics features, response to therapy and overall survival. Three models based on texture and clinical variables and a combination of them were finally built; (3) Results: Entropy, skewness, MPP and kurtosis showed a significant correlation with complete response (CR) to TACE (all p < 0.001). A predictive model to identify patients with a high and low probability of CR was evaluated with an ROC curve, with an AUC of 0.733 (p < 0.001). The three models built for survival prediction yielded an HR of 2.19 (95% CI: 2.03–2.35) using texture features, of 1.7 (95% CI: 1.54–1.9) using clinical data and of 4.61 (95% CI: 4.24–5.01) combining both radiomics and clinical data (all p < 0.0001). (4) Conclusion: Texture analysis based on pre-treatment CT examination is associated with response to therapy and survival in patients with HCC undergoing DEB-TACE, especially if combined with clinical data.

Independent prognostic value of pre-treatment 18-FDG-PET in high-grade gliomas

2011 ◽  
Vol 107 (3) ◽  
pp. 527-535 ◽  
Author(s):  
Cécile Colavolpe ◽  
Philippe Metellus ◽  
Julien Mancini ◽  
Maryline Barrie ◽  
Céline Béquet-Boucard ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Prognostic Value ◽  
High Grade ◽  
High Grade Gliomas ◽  
Pre Treatment

Prognostic value of pre-treatment 18F-FDG-PET uptake in small-cell lung cancer

2017 ◽  
Vol 31 (6) ◽  
pp. 462-468 ◽  
Author(s):  
Meryem Aktan ◽  
Mehmet Koc ◽  
Gul Kanyilmaz ◽  
Berrin Benli Yavuz
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Fdg Pet ◽  
Prognostic Value ◽  
Small Cell ◽  
Small Cell Lung ◽  
18F Fdg ◽  
Pre Treatment

O56 Prognostic value of FDG-PET in Hodgkin lymphoma for post-treatment evaluation. Long-term follow-up

Blood Reviews ◽  
2007 ◽  
Vol 21 ◽  
pp. S84 ◽  
Author(s):  
Zs. Molnár ◽  
Z. Borbényi ◽  
L. Galuska ◽  
K. Keresztes ◽  
I. Marton ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Fdg Pet ◽  
Prognostic Value ◽  
Treatment Evaluation ◽  
Post Treatment ◽  
Long Term Follow Up

scholarly journals Additional Value of 2-[18F]FDG PET/CT Comparing to MRI in Treatment Approach of Anal Cancer Patients

2020 ◽  
Vol 9 (9) ◽  
pp. 2715
Author(s):  
Reyhaneh Manafi-Farid ◽  
Alexander Kupferthaler ◽  
Helwig Wundsam ◽  
Georg Gruber ◽  
Reza Vali ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Anal Cancer ◽  
Fdg Pet ◽  
Prognostic Value ◽  
Number Of Patients ◽  
Pet Ct ◽  
18F Fdg ◽  
Pre Treatment ◽  
Fdg Pet Ct ◽  
The Impact

Accurate staging and treatment planning are imperative for precise management in Anal Cancer (ACa) patients. We aimed to evaluate the additive and prognostic value of pre-treatment 2-[18F]fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (2-[18F]FDG PET/CT) in the staging and management of ACa compared to magnetic resonance imaging (MRI). This retrospective study was conducted on 54 patients. Pre-treatment 2-[18F]FDG PET/CT studies and MRI reports were compared considering the primary tumor, pelvic lymph nodes, and metastatic lesions. The impact of 2-[18F]FDG PET/CT in the management and its prognostic value, using maximum standardized uptake value (SUVmax), were assessed. Discordant findings were found in 46.3% of patients (5 in T; 1 in T and N; 18 in N; and 1 in M stage). 2-[18F]FDG PET/CT resulted in up-staging in 9.26% and down-staging in 3.7% of patients. Perirectal lymph nodes were metabolically inactive in 12.9% of patients. Moreover, 2-[18F]FDG PET/CT resulted in management change in 24.1% of patients. Finally, SUVmax provided no prognostic value. 2-[18F]FDG PET/CT altered staging and management in a sizable number of patients in this study, and supports a need for a change in guidelines for it to be used as a routine complementary test in the initial management of ACa.

scholarly journals PET2015UZ: Prognostic value of pre-treatment 18FDG-PET in operable breast cancer v1

2020 ◽  
Author(s):  
Vincent Vinh-Hung ◽  
Hendrik Everaert ◽  
Mark De Ridder
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Survival Data ◽  
Fdg Pet ◽  
Prognostic Value ◽  
18Fdg Pet ◽  
Prediction Of Survival ◽  
Node Ratio ◽  
Pre Treatment ◽  
Overall Survival Analysis

This retrospective-observational study hypothesizes that preoperative 18FDG-PET for breast cancer has significant prognostic value for the prediction of survival. Data from patients who had breast surgery and had a preoperative FDG-PET examination at the UZ Brussel in 2002-2008 and in 2009-2015 will be analyzed without restriction on age or sex. Data collection for the cohort 2002-2008 has been finalized and will be shared on Mendeley (Reserved DOI: 10.17632/sfvtmrd8z9.1 ). Data for the cohort 2009-2015 will be collected by end of 2020. Detailed and referred to in: # Breast cancer preoperative 18FDG-PET, overall survival prognostic separation compared with the lymph node ratio. # Vinh-Hung V, Everaert H, Gorobets O, Van Parijs H, Verfaillie G, Vanhoeij M, Storme G, Fontaine C, Lamote J, Perrin J, Farid K, Nguyen NP, Verschraegen C, De Ridder M. # Breast Cancer. 2021 Jul;28(4):956-968. doi: 10.1007/s12282-021-01234-z # PMID: 33689151 https://link.springer.com/article/10.1007%2Fs12282-021-01234-z # Is there a utility of [18F]FDG-PET before surgery in breast cancer? A 15-years overall survival analysis. # Perrin, Farid K, Van Parijs H, Gorobets O, Vinh-Hung V, Nguyen NP, Djassemi N, De Ridder M, Everaert H. # World J Clin Oncol. Pending. Study registration: https://www.isrctn.com/ISRCTN17962845

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