scholarly journals Metabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in Catalysis

2018 ◽  
Vol 46 (4) ◽  
pp. 429-439 ◽  
Author(s):  
Hong Liu ◽  
David M. Stresser ◽  
Melissa J. Michmerhuizen ◽  
Xiaofeng Li ◽  
Ahmed A. Othman ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Receptor Agonist ◽  
Neuronal Acetylcholine Receptor ◽  
Glucuronosyl Transferase

Species-dependent metabolism of a novel selective α7 neuronal acetylcholine receptor agonist ABT-107

Xenobiotica ◽  
2013 ◽  
Vol 43 (9) ◽  
pp. 803-816 ◽  
Author(s):  
Hong Liu ◽  
Xiaoqing Deng ◽  
Jinrong Liu ◽  
Ning Liu ◽  
Patricia Stuart ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Receptor Agonist ◽  
Neuronal Acetylcholine Receptor

Synthesis and Pharmacological Characterization of Novel Analogues of the Nicotinic Acetylcholine Receptor Agonist (±)-UB-165

2002 ◽  
Vol 45 (15) ◽  
pp. 3235-3245 ◽  
Author(s):  
Christopher G. V. Sharples ◽  
Gunter Karig ◽  
Graham L. Simpson ◽  
James A. Spencer ◽  
Emma Wright ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Receptor Agonist ◽  
Pharmacological Characterization ◽  
Nicotinic Acetylcholine

Metabolism and disposition of ABT-894, a novelα4β2 neuronal acetylcholine receptor agonist, in mice and monkeys

Xenobiotica ◽  
2014 ◽  
Vol 44 (6) ◽  
pp. 531-540 ◽  
Author(s):  
Hong Liu ◽  
Wentao Fu ◽  
Jill Wetter ◽  
Hongyu Xu ◽  
Zhiwen Guan ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Receptor Agonist ◽  
Neuronal Acetylcholine Receptor
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