Advanced bandages for diabetic wound healing

2021 ◽  
Vol 13 (585) ◽  
pp. eabe4839
Author(s):  
Simon Matoori ◽  
Aristidis Veves ◽  
David J. Mooney
Keyword(s):  
Wound Healing ◽  
Treatment Options ◽  
Current Treatment ◽  
Wound Dressings ◽  
Foot Ulcers ◽  
Diabetic Wound ◽  
Recent Advances ◽  
Diabetic Wound Healing

Current treatment options for foot ulcers, a serious and prevalent complication of diabetes, remain nonspecific. In this Perspective, we present recent advances in understanding the pathophysiology of diabetic wound healing and the emergence of previously unidentified targets. We discuss wound dressings tailored to the diabetic wound environment currently under development.

Therapeutic Properties of Honey for the Management of Wounds; Is There a Role in the Armamentarium of Diabetic Foot Ulcer Treatment? Results From In vitro and In vivo Studies

2021 ◽  
pp. 153473462110268
Author(s):  
Ioanna A. Anastasiou ◽  
Ioanna Eleftheriadou ◽  
Anastasios Tentolouris ◽  
Georgia Samakidou ◽  
Nikolaos Papanas ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Diabetic Animal ◽  
Cochrane Library ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Therapeutic Properties

Diabetic foot ulcers are one of the most dreadful complications of diabetes mellitus and efforts to accelerate diabetic wound healing are of paramount importance to prevent ulcer infections and subsequent lower-limb amputations. There are several treatment approaches for the management of diabetic foot ulcers and honey seems to be a safe and cost-effective therapeutic approach on top of standard of care. The aim of this review was to summarize the therapeutic properties of honey and the data regarding its possible favorable effects on diabetic wound healing. A literature search of articles from 1986 until April 2021 was performed using MEDLINE, EMBASE, and the Cochrane Library to assess for studies examining the therapeutic wound healing properties of honey, it's in vitro effect, and the efficacy and/or mechanism of action of several types of honey used for the treatment of diabetic animal wounds. Honey has antioxidant, anti-inflammatory, and antibacterial properties and in vitro studies of keratinocytes and fibroblasts, as well as studies in diabetic animal models show that treatment with honey is associated with increased re-epithelialization and collagen production, higher wound contraction, and faster wound healing. The use of honey could be a promising approach for the management of diabetic foot ulcers.

scholarly journals Study of hydrocellular functional material as microbicidal wound dressing for diabetic wound healing

2021 ◽  
Vol 19 ◽  
pp. 228080002110549
Author(s):  
Michael Rodrigues ◽  
Thilagavati Govindharajan
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Wound Care ◽  
Cost Effective ◽  
Wound Dressings ◽  
Wound Management ◽  
Histopathological Analysis ◽  
Diabetic Wound ◽  
Functional Material ◽  
Diabetic Wound Healing

A hydrocellular functional material as a wound dressing is developed and it is found to be superior in its efficacy as compared to some of the comparator controls in diabetic wound healing studies. A study on wound contraction and Histopathological analysis is done in rats. The efficacy of the dressing is comparable to the established wound dressings like Carboxymethyl cellulose alginate dressings and autolytic enzyme based hydrogel. It is found to be superior to Polyhexamethylene biguanide dressing used as reference controls in this study. The reason for good wound healing performance of the dressing can be attributed to a combined property of effective exudates management and broad spectrum antimicrobial effect. The concept of functional hydro cellular material has shown good results due to the excellent balance of exudates pickup and drying it out. This ensures moist wound healing conditions on the wound. Because of its porous nature it allows good air flow and gaseous exchange in the structure. The cationic sites created on the surface of the dressing ensure a good antimicrobial action on the exudates in the dressing. It reduces the infection load on the wound. The nonleaching property of the dressing also helps in preventing the generation of more resistant and mutant strains of the microbes. The developed dressing can be used as a relatively durable long lasting dressing for wound management in diabetic wounds. The need of repetitive wound dressing changes can be brought down with this concept of dressing. It is not only cost effective in terms of its material cost but also is a cost effective solution when entire wound management cost is considered. Such novel wound dressing material can change the quality of life of diabetic wound patients especially in developing world, where access to functional advanced wound care dressings is limited.

The Potency of Wound Healing of Nanogel Containing Mikania Micrantha Leaves Extract in Hyperglycemic Rats

2021 ◽  
Vol 09 ◽  
Author(s):  
Imam Bagus Sumantri ◽  
Ismayadi ◽  
Lolyta Fitri Mustanti
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Wound Healing ◽  
Healing Process ◽  
Wound Dressings ◽  
Gelling Agent ◽  
Diabetic Wound ◽  
Mikania Micrantha ◽  
Staphylococcus Epidermis ◽  
Diabetic Wound Healing

Introduction: Mikania micrantha has been used traditionally for wound dressings and promoted the healing of sores. This is due to the content of alkaloids and terpenoids/steroids compounds. Hyperglycemic is a good medium for bacterial growth and inhibits the wound healing process. Purpose: This study aimed to determine the wound healing of nanogels containing MMLE in hyperglycemic rats, as a model for diabetic wounds. Methods: Mikania micrantha leaves were extracted with the maceration method using ethanol 96% in 5 days. Carbopol 940 was used as the gelling agent. The parameters observed during the physical testing of nanogels were organoleptic, homogeneity, pH, and size of the particle. Antibacterial activity was tested on Staphylococcus aureus, Staphylococcus epidermis, Escherichia coli, and wound healing activity in hyperglycemic rats for 14 days observation. Diabetic wound healing was treated with 4 groups (P1, P2, K1, K2). Data were analyzed using SPSS. Results: Nanogel showed homogeneity, dark green color, transparency, pH 6.1± 0.1, and particle size range in 255-456 nm. Inhibition zone of antibacterial testing i.e. Staphylococcus aureus, Staphylococcus epidermis, and Escherichia coli was 10.57 ± 0.26 mm; 9.73 ± 0.21 mm; 8.4 ± 0.1 mm. The percentage of diabetic wound healing was in the range of 92.79±3.81% to 94.08 ± 2.33% for 14 days of observation. Conclusion: MMLE nanogels have the potential as a treatment for diabetic wound healing.

Wound Dressings Based on Rubidium-Doped Bioactive Glass Nanospheres Promote Diabetic Wound Healing

2019 ◽  
Vol 15 (10) ◽  
pp. 2059-2071 ◽  
Author(s):  
Xiang He ◽  
Yufang Ding ◽  
Saili Duan ◽  
Songzhu Luo ◽  
Jian Song ◽  
...  
Keyword(s):  
Wound Healing ◽  
Bioactive Glass ◽  
Wound Dressings ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

Single Cell RNA-Seq Analyses of Healthy Lower Extremity Skin and Diabetic Foot Ulcers Uncover Distinct Immune Landscape of Diabetic Wound Healing

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 647-P ◽  
Author(s):  
GEORGIOS THEOCHARIDIS ◽  
SWATI S. BHASIN ◽  
KONSTANTINOS KOUNAS ◽  
MANOJ K. BHASIN ◽  
ARISTIDIS VEVES
Keyword(s):  
Wound Healing ◽  
Lower Extremity ◽  
Single Cell ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Diabetic Wound ◽  
Rna Seq ◽  
Diabetic Wound Healing

Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing In Vivo

2015 ◽  
Vol 28 (9) ◽  
pp. 1809-1817 ◽  
Author(s):  
Steven A. Castleberry ◽  
Benjamin D. Almquist ◽  
Wei Li ◽  
Tiago Reis ◽  
John Chow ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressings ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Self Assembled

Bioactive Self‐Pumping Composite Wound Dressings with Micropore Array Modified Janus Membrane for Enhanced Diabetic Wound Healing

2020 ◽  
Vol 30 (49) ◽  
pp. 2005422 ◽  
Author(s):  
Feng Bao ◽  
Ge Pei ◽  
Zhongcao Wu ◽  
Hui Zhuang ◽  
Zhaowenbin Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressings ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

Enhanced diabetic wound healing by electrospun core–sheath fibers loaded with dimethyloxalylglycine

2018 ◽  
Vol 6 (2) ◽  
pp. 277-288 ◽  
Author(s):  
W. Gao ◽  
L. Sun ◽  
X. Fu ◽  
Z. Lin ◽  
W. Xie ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressings ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

DMOG-loaded nanofibrous wound dressings enhanced diabetic wound healing by stabilizing HIF-1α.

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