scholarly journals Study of hydrocellular functional material as microbicidal wound dressing for diabetic wound healing

2021 ◽  
Vol 19 ◽  
pp. 228080002110549
Author(s):  
Michael Rodrigues ◽  
Thilagavati Govindharajan
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Wound Care ◽  
Cost Effective ◽  
Wound Dressings ◽  
Wound Management ◽  
Histopathological Analysis ◽  
Diabetic Wound ◽  
Functional Material ◽  
Diabetic Wound Healing

A hydrocellular functional material as a wound dressing is developed and it is found to be superior in its efficacy as compared to some of the comparator controls in diabetic wound healing studies. A study on wound contraction and Histopathological analysis is done in rats. The efficacy of the dressing is comparable to the established wound dressings like Carboxymethyl cellulose alginate dressings and autolytic enzyme based hydrogel. It is found to be superior to Polyhexamethylene biguanide dressing used as reference controls in this study. The reason for good wound healing performance of the dressing can be attributed to a combined property of effective exudates management and broad spectrum antimicrobial effect. The concept of functional hydro cellular material has shown good results due to the excellent balance of exudates pickup and drying it out. This ensures moist wound healing conditions on the wound. Because of its porous nature it allows good air flow and gaseous exchange in the structure. The cationic sites created on the surface of the dressing ensure a good antimicrobial action on the exudates in the dressing. It reduces the infection load on the wound. The nonleaching property of the dressing also helps in preventing the generation of more resistant and mutant strains of the microbes. The developed dressing can be used as a relatively durable long lasting dressing for wound management in diabetic wounds. The need of repetitive wound dressing changes can be brought down with this concept of dressing. It is not only cost effective in terms of its material cost but also is a cost effective solution when entire wound management cost is considered. Such novel wound dressing material can change the quality of life of diabetic wound patients especially in developing world, where access to functional advanced wound care dressings is limited.

Advanced bandages for diabetic wound healing

2021 ◽  
Vol 13 (585) ◽  
pp. eabe4839
Author(s):  
Simon Matoori ◽  
Aristidis Veves ◽  
David J. Mooney
Keyword(s):  
Wound Healing ◽  
Treatment Options ◽  
Current Treatment ◽  
Wound Dressings ◽  
Foot Ulcers ◽  
Diabetic Wound ◽  
Recent Advances ◽  
Diabetic Wound Healing

Current treatment options for foot ulcers, a serious and prevalent complication of diabetes, remain nonspecific. In this Perspective, we present recent advances in understanding the pathophysiology of diabetic wound healing and the emergence of previously unidentified targets. We discuss wound dressings tailored to the diabetic wound environment currently under development.

Asymmetric Wettable Composite Wound Dressing Prepared by Electrospinning with Bioinspired Micropatterning Enhances Diabetic Wound Healing

2020 ◽  
Vol 3 (8) ◽  
pp. 5383-5394 ◽  
Author(s):  
Bangrui Yu ◽  
Chenhui He ◽  
Weibin Wang ◽  
Yafeng Ren ◽  
Jianmin Yang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

scholarly journals Potential of Cyanobacteria in Wound Healing

2021 ◽  
Author(s):  
Laxmi Parwani ◽  
Mansi Shrivastava ◽  
Jaspreet Singh
Keyword(s):  
Wound Healing ◽  
Bioactive Compounds ◽  
Wound Care ◽  
Cost Effective ◽  
Wound Dressings ◽  
Potential Applications ◽  
Healing Agent ◽  
The Rich ◽  
Immense Potential ◽  
Insight Into

The wound care market is rapidly expanding due to the development of innumerable dressings that exhibit specific healing requirements for different wound types. The use of biomaterials as suitable wound dressing material is highly advantageous due to their biocompatibility, biodegradability, and non-toxicity. Cyanobacteria have been widely explored for their potential applications in wound healing, as they are the rich source of bioactive compounds with antibacterial, antitumor, antiviral, antioxidant, and antifungal activities. In recent years this group of organisms has been widely studied due to their immense potential in biomedical applications. Although their different bioactivities can support wound healing in different ways, very few forms have proven utility as a wound-healing agent. This chapter gives an insight into the potential of cyanobacteria in wound healing. Different bioactive compounds present in variable forms of cyanobacteria and their associated activities were reported to support tissue regeneration and wound healing acceleration. As the demand for cost-effective, bioactive wound care products is ever increasing, these organisms have immense potential to be utilized for the development of bioactive wound dressings. Hence, various bioactive compounds of cyanobacteria, their associated activities, and roles in wound healing have been briefly reviewed in this chapter.

scholarly journals Collagen-Based Nanofibers for Skin Regeneration and Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 4368
Author(s):  
Zintle Mbese ◽  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Cellular Proliferation ◽  
Healing Process ◽  
Skin Regeneration ◽  
Wound Dressings ◽  
Wound Management ◽  
Major Constituent ◽  
Wound Healing Process ◽  
Frequent Change

Skin regeneration after an injury is very vital, but this process can be impeded by several factors. Regenerative medicine is a developing biomedical field with the potential to decrease the need for an organ transplant. Wound management is challenging, particularly for chronic injuries, despite the availability of various types of wound dressing scaffolds in the market. Some of the wound dressings that are in clinical practice have various drawbacks such as poor antibacterial and antioxidant efficacy, poor mechanical properties, inability to absorb excess wound exudates, require frequent change of dressing and fails to offer a suitable moist environment to accelerate the wound healing process. Collagen is a biopolymer and a major constituent of the extracellular matrix (ECM), making it an interesting polymer for the development of wound dressings. Collagen-based nanofibers have demonstrated interesting properties that are advantageous both in the arena of skin regeneration and wound dressings, such as low antigenicity, good biocompatibility, hemostatic properties, capability to promote cellular proliferation and adhesion, and non-toxicity. Hence, this review will discuss the outcomes of collagen-based nanofibers reported from the series of preclinical trials of skin regeneration and wound healing.

scholarly journals Collagen Based Sponges for Wound Healing

2019 ◽  
Vol 9 (2S2) ◽  
pp. 916-920
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Wound Repair ◽  
Wound Dressings ◽  
Wound Management ◽  
Repair System ◽  
Tissue Formation ◽  
Fish Scales ◽  
Healing Efficiency ◽  
The Common

Nowadays, wound healing is the common and simple problems occur in our society. Wound healing is the multi factorial process which includes inflammation, reepithelialisation, collagen deposition, and angiogenesis. Wound repair system is indispensable to enhance the proper functioning of skin. Normally, wound dressing is either momentary or lasting, wound dressings has been intended to improve the wound repair. Those wound dressing are required to wrap the large surfaced open wounds such as widespread burns, pressure ulcers, foot sores etc., wound healing substance should have some important features such as, high healing efficiency, anti-scar formation, providing favourable atmosphere for wound management. The collagen plays an important role in tissue formation and has more effect on wound healing. In this work collagen sponge is prepared from fish scales and to increase the antibacterial efficacy need extract has been added.

scholarly journals Hydro-Alcoholic Root Extracts of Ziziphus abyssinica is Effective in Diabetes Nephropathy and Diabetic Wound Healing

2021 ◽  
pp. 19-29
Author(s):  
Samuel A. Akwetey ◽  
Douglas B. Aidoo ◽  
Wisdom Ahlidja ◽  
Bright B. Boafo ◽  
Joseph M. Acquah ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Nephropathy ◽  
Blood Glucose ◽  
Blood Glucose Concentration ◽  
Negative Control ◽  
Diabetic Rats ◽  
Histopathological Analysis ◽  
Root Extract ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

Background: This study evaluated the potential of Ziziphus abysinnica root extract in managing hyperglycaemia in type 2 diabetes mellitus (T2DM), diabetic wound healing and diabetic nephropathy. Methodology: Blood glucose concentrations were measured daily for 14 days after daily administrations of either Ziziphus abysinnica (30, 100, and 300 mg/kg, p.o), metformin (300 mg/kg, p.o) or normal saline as negative control before diabetes induction using a single dose of Streptozotocin (60 mg/kg, i.p) and nicotinamide (120 mg/kg, i.p). Histopathological analysis was performed on the harvested kidneys following administration with Ziziphus abysinnica in diabetic rats. The diabetic wound healing potentials of the plant was also evaluated in streptozotocin-induced diabetic rats by treating them with 15%w/w ZAE ointment. Results: Generally, the percentage of blood glucose levels analysed following administration of drugs were found to be dose-dependent. The highest dose of ZAE (300 mg/kg) had a higher percentage reduction in blood glucose concentration when compared to metformin (300 mg/kg).  The lowest dose (30 mg/kg) of ZAE administered attenuated STZ induced pathological damage and showed moderate to maximal improvement to the kidney nephrons. In contrast, the 100 mg/kg and 300 mg/kg dose ZAE demonstrated minimal pathological changes to the kidney architecture. Conclusion: Overall, our study demonstrated the antidiabetic potential of Ziziphus abysinnica, suggesting its possible therapeutic benefit in diabetic wound healing and diabetic nephropathy. 

scholarly journals Analysis of Wound Care Management in the Case of Diabetic Injury at Emergency Installation (IGD) Arifin Nu'mang Hospital of Sidrap Regency

2018 ◽  
pp. 116-124
Author(s):  
Damsir Eni Ungke
Keyword(s):  
Diabetes Mellitus ◽  
Wound Healing ◽  
Normal Saline ◽  
Wound Care ◽  
Healing Process ◽  
Skin Surface ◽  
Wound Healing Process ◽  
Diabetic Wound ◽  
Open Wound ◽  
Diabetic Wound Healing

Diabetic injury is one form of chronic complications. Diabetes mellitus is an open wound on the skin surface that can be accompanied by local tissue death. Diabetes mellitus patients at risk of 29 times the occurrence of diabetic injuries. Diabetic injury is an open wound on the skin surface caused by the presence of macroangiopathy resulting in vascular insusifiensi and neuropati. Organs most often affected by diabetes mellitus complications include the leg blood vessels. Disorders of blood vessels that often occur in diabetes that is on the legs and feet. This study aims to determine the effectiveness of wound care using modern bandage (Metcofazin) on diabetic wound healing process at Emergency Hospital (IGD) Arifin Nu'mang Hospital of Sidrap Regency, and to know the effectiveness of wound care using conventional dressing (normal saline saline NaCl 0 , 9% and gauze bandage) to diabetic wound healing process at Emergency Injury Installation (IGD) Arifin Nu'mang Hospital of Sidrap Regency. The type of research used by the researcher is qualitative research with case study approach. This research has been conducted on 21 November until December 21, 2014 at the Emergency Installation (IGD) Arifin Nu'mang Hospital, Sidrap Regency. Samples used in this study are patients with diabetic injuries at Arifin Nu'mang Hospital Sidrap District with sampling technique by puposive sampling. The results of this study indicate that the treatment of luk a using a modern bandage (metcofazine) is more effective than wound care using conventional dressing (normal saline 0.9% NaCl saline and gauze dressing) on ​​diabetic wound healing process at Arifin Nu'mang Hospital Sidrap Hospital.

The Potency of Wound Healing of Nanogel Containing Mikania Micrantha Leaves Extract in Hyperglycemic Rats

2021 ◽  
Vol 09 ◽  
Author(s):  
Imam Bagus Sumantri ◽  
Ismayadi ◽  
Lolyta Fitri Mustanti
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Wound Healing ◽  
Healing Process ◽  
Wound Dressings ◽  
Gelling Agent ◽  
Diabetic Wound ◽  
Mikania Micrantha ◽  
Staphylococcus Epidermis ◽  
Diabetic Wound Healing

Introduction: Mikania micrantha has been used traditionally for wound dressings and promoted the healing of sores. This is due to the content of alkaloids and terpenoids/steroids compounds. Hyperglycemic is a good medium for bacterial growth and inhibits the wound healing process. Purpose: This study aimed to determine the wound healing of nanogels containing MMLE in hyperglycemic rats, as a model for diabetic wounds. Methods: Mikania micrantha leaves were extracted with the maceration method using ethanol 96% in 5 days. Carbopol 940 was used as the gelling agent. The parameters observed during the physical testing of nanogels were organoleptic, homogeneity, pH, and size of the particle. Antibacterial activity was tested on Staphylococcus aureus, Staphylococcus epidermis, Escherichia coli, and wound healing activity in hyperglycemic rats for 14 days observation. Diabetic wound healing was treated with 4 groups (P1, P2, K1, K2). Data were analyzed using SPSS. Results: Nanogel showed homogeneity, dark green color, transparency, pH 6.1± 0.1, and particle size range in 255-456 nm. Inhibition zone of antibacterial testing i.e. Staphylococcus aureus, Staphylococcus epidermis, and Escherichia coli was 10.57 ± 0.26 mm; 9.73 ± 0.21 mm; 8.4 ± 0.1 mm. The percentage of diabetic wound healing was in the range of 92.79±3.81% to 94.08 ± 2.33% for 14 days of observation. Conclusion: MMLE nanogels have the potential as a treatment for diabetic wound healing.

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