Affinity of Doripenem and Comparators to Penicillin-Binding Proteins in Escherichia coli and Pseudomonas aeruginosa
2008 ◽
Vol 52
(4)
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pp. 1510-1512
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Keyword(s):
ABSTRACT Doripenem, a parenteral carbapenem, exhibited high affinity for penicillin-binding protein 2 (PBP2) and PBP3 in Pseudomonas aeruginosa and PBP2 in Escherichia coli, the primary PBPs whose inhibition leads to cell death. This PBP affinity profile correlates with the broad-spectrum gram-negative activity observed with doripenem.
2008 ◽
Vol 53
(3)
◽
pp. 1238-1241
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2007 ◽
Vol 51
(7)
◽
pp. 2621-2624
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2010 ◽
Vol 54
(9)
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pp. 3933-3937
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2014 ◽
Vol 59
(3)
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pp. 1789-1793
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1979 ◽
Vol 16
(3)
◽
pp. 325-328
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1983 ◽
Vol 12
(2)
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pp. 119-126
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1986 ◽
Vol 30
(6)
◽
pp. 906-912
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1979 ◽
Vol 15
(1)
◽
pp. 20-27
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2004 ◽
Vol 186
(13)
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pp. 4412-4416
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Keyword(s):