In VitroSusceptibility of Characterized β-Lactamase-Producing Strains Tested with Avibactam Combinations
2014 ◽
Vol 59
(3)
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pp. 1789-1793
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Keyword(s):
ABSTRACTAvibactam, a broad-spectrum β-lactamase inhibitor, was tested with ceftazidime, ceftaroline, or aztreonam against 57 well-characterized Gram-negative strains producing β-lactamases from all molecular classes. Most strains were nonsusceptible to the β-lactams alone. Against AmpC-, extended-spectrum β-lactamase (ESBL)-, and KPC-producingEnterobacteriaceaeorPseudomonas aeruginosa, avibactam lowered ceftazidime, ceftaroline, or aztreonam MICs up to 2,048-fold, to ≤4 μg/ml. Aztreonam-avibactam MICs against a VIM-1 metallo-β-lactamase-producingEnterobacter cloacaeand a VIM-1/KPC-3-producingEscherichia coliisolate were 0.12 and 8 μg/ml, respectively.
2001 ◽
Vol 14
(4)
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pp. 933-951
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Keyword(s):
2014 ◽
Vol 58
(4)
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pp. 2434-2437
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Keyword(s):
2015 ◽
Vol 59
(9)
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pp. 5834-5837
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Keyword(s):