scholarly journals Horizontal Gene Transfer and Assortative Recombination within the Acinetobacter baumannii Clinical Population Provide Genetic Diversity at the Single carO Gene, Encoding a Major Outer Membrane Protein Channel

2011 ◽  
Vol 193 (18) ◽  
pp. 4736-4748 ◽  
Author(s):  
M. A. Mussi ◽  
A. S. Limansky ◽  
V. Relling ◽  
P. Ravasi ◽  
A. Arakaki ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Gene Transfer ◽  
Horizontal Gene Transfer ◽  
Membrane Protein ◽  
Acinetobacter Baumannii ◽  
Outer Membrane ◽  
Outer Membrane Protein ◽  
Clinical Population ◽  
Gene Encoding ◽  
Protein Channel

scholarly journals Cloning and Functional Analysis of the Gene Encoding the 33- to 36-Kilodalton Outer Membrane Protein Associated with Carbapenem Resistance in Acinetobacter baumannii

2005 ◽  
Vol 49 (12) ◽  
pp. 5172-5175 ◽  
Author(s):  
Maria del Mar Tomás ◽  
Alejandro Beceiro ◽  
Astrid Pérez ◽  
David Velasco ◽  
Rita Moure ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Membrane Protein ◽  
Acinetobacter Baumannii ◽  
Outer Membrane ◽  
Outer Membrane Protein ◽  
Outer Membrane Proteins ◽  
Carbapenem Resistance ◽  
Peptide Sequence ◽  
Gene Encoding ◽  
Multiresistant Strain

ABSTRACT We investigated a multiresistant strain of Acinetobacter baumannii isolated in our hospital. Analysis of the N-terminal peptide sequence of the outer membrane proteins (OMPs) purified from the strain allowed us to clone and sequence the nucleotides of the gene encoding the 33- to 36-kDa OMP associated with carbapenem resistance in A. baumannii

scholarly journals Opening of the Outer Membrane Protein Channel in Tripartite Efflux Pumps Is Induced by Interaction with the Membrane Fusion Partner

2010 ◽  
Vol 286 (7) ◽  
pp. 5484-5493 ◽  
Author(s):  
Thamarai K. Janganan ◽  
Li Zhang ◽  
Vassiliy N. Bavro ◽  
Dijana Matak-Vinkovic ◽  
Nelson P. Barrera ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Membrane Fusion ◽  
Outer Membrane ◽  
Outer Membrane Protein ◽  
Efflux Pumps ◽  
Fusion Partner ◽  
Protein Channel

scholarly journals Conservation of msp, the gene encoding the major outer membrane protein of oral Treponema spp.

1997 ◽  
Vol 179 (4) ◽  
pp. 1082-1089 ◽  
Author(s):  
J C Fenno ◽  
G W Wong ◽  
P M Hannam ◽  
K H Müller ◽  
W K Leung ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Outer Membrane ◽  
Outer Membrane Protein ◽  
Major Outer Membrane Protein ◽  
Gene Encoding

scholarly journals Identification of a Siderophore Receptor Required for Ferric Ornibactin Uptake in Burkholderia cepacia

2000 ◽  
Vol 68 (12) ◽  
pp. 6554-6560 ◽  
Author(s):  
P. A. Sokol ◽  
P. Darling ◽  
S. Lewenza ◽  
C. R. Corbett ◽  
C. D. Kooi
Keyword(s):  
Membrane Protein ◽  
Outer Membrane ◽  
Outer Membrane Protein ◽  
Burkholderia Cepacia ◽  
Parent Strain ◽  
Respiratory Infections ◽  
Infection Model ◽  
Protein Profiles ◽  
Outer Membrane Receptor ◽  
Gene Encoding

ABSTRACT Ornibactins are linear hydroxamate siderophores produced byBurkholderia cepacia with peptide structures similar to that of pyoverdines produced by the fluorescent pseudomonads. The gene encoding the outer membrane receptor (orbA) was identified, sequenced, and demonstrated to have significant homology with hydroxamate receptors produced by other organisms. The orbAprecursor was predicted to be a protein with a molecular mass of 81 kDa. An orbA mutant was constructed and demonstrated to be unable to take up 59Fe-ornibactins or to grow in medium supplemented with ornibactins. Outer membrane protein profiles from the parent strain, K56-2, revealed an iron-regulated outer membrane protein of 78 kDa that was not detectable in the K56orbA::tp mutant. When this mutant harbored a plasmid containing the orbA gene, the 78-kDa protein was present in the outer membrane protein profiles and the mutant was able to utilize ornibactin to acquire iron. The orbA mutant was less virulent in a chronic respiratory infection model than the parent strain, indicating that ornibactin uptake and utilization are important in the pathogenesis of B. cepacia respiratory infections.

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