Requirements for Nitric Oxide Generation from Isoniazid Activation In Vitro and Inhibition of Mycobacterial Respiration In Vivo
2004 ◽
Vol 186
(16)
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pp. 5427-5431
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Keyword(s):
ABSTRACT Isoniazid (INH), a front-line antituberculosis agent, is activated by mycobacterial catalase-peroxidase KatG, converting INH into bactericidal reactive species. Here we investigated the requirements and the pathway of nitric oxide (NO˙) generation during oxidative activation of INH by Mycobacterium tuberculosis KatG in vitro. We also provide in vivo evidence that INH-derived NO˙ can inhibit key mycobacterial respiratory enzymes, which may contribute to the overall antimycobacterial action of INH.
2003 ◽
Vol 198
(5)
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pp. 705-713
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2001 ◽
Vol 183
(13)
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pp. 4033-4039
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Keyword(s):
2019 ◽
Vol 12
(1)
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pp. 27-49
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Keyword(s):
Keyword(s):
2021 ◽
Vol 18
(3)
◽
pp. 980
Keyword(s):