Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral Therapy
1999 ◽
Vol 73
(1)
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pp. 797-800
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Keyword(s):
ABSTRACT Little is known of the changes in human immunodeficiency virus type 1 (HIV-1)-specific effector cytotoxic T lymphocytes (CTL) after potent antiretroviral therapy. Using HLA/peptide tetrameric complexes, we show that after starting treatment, there are early rapid fluctuations in the HIV-1-specific CTL response which last 1 to 2 weeks. These fluctuations are followed by an exponential decay (median half-life, 45 days) of HIV-1-specific CTL which continues while viremia remains undetectable. These data have implications for the immunological control of drug-resistant virus.
1994 ◽
Vol 180
(4)
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pp. 1283-1293
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2001 ◽
Vol 184
(11)
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pp. 1465-1469
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1993 ◽
Vol 67
(6)
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pp. 3409-3417
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2000 ◽
Vol 74
(14)
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pp. 6695-6699
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2003 ◽
Vol 77
(5)
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pp. 3077-3083
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1993 ◽
Vol 9
(1)
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pp. 61-68
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1999 ◽
Vol 73
(8)
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pp. 7065-7069
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1996 ◽
Vol 77
(8)
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pp. 1659-1665
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2018 ◽
Vol 69
(8)
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pp. 1345-1352
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