scholarly journals Long-Term Temporal Stability of the Resistome in Sewage from Copenhagen

mSystems ◽  
2020 ◽  
Vol 5 (5) ◽  
Author(s):  
Christian Brinch ◽  
Pimlapas Leekitcharoenphon ◽  
Ana S. R. Duarte ◽  
Christina A. Svendsen ◽  
Jacob D. Jensen ◽  
...  

ABSTRACT Antimicrobial resistance (AMR) is a major threat to global health, and it is crucial to understand the epidemiological aspects in order to predict the emergence and propagation of AMR genes. The aim of this study was to assess the variability and medium-term AMR trends within the mostly healthy human population of a single city. We monitored over 36 months (November 2015 to November 2018) the AMR level in the city of Copenhagen, Denmark, by taking bi-weekly sewage samples from the inlets of the three main water treatment plants, extracting the DNA, performing metagenomic sequencing, and read-mapping against a database of known AMR genes. We found that the AMR level was surprisingly stable with no periodic variability and no signs of drift over the measured period. We found, however, that the seemingly random variations at each site correlate in time with each other, suggesting that the variations we see are due to real environmental changes in the occurrence of AMR. IMPORTANCE The Copenhagen sewage resistome is surprisingly stable in time. The implication is that, at least for cities that are comparable to Copenhagen in terms of sewer infrastructure, few or even single samples provide a robust picture of the resistome within a city.

2014 ◽  
Vol 38 (3) ◽  
pp. 198-204 ◽  
Author(s):  
Samir Younés

Architects who understand the need to build enduringly are faced with the almost complete absence of international agreements with respect to a planetary ecological project. The coming environmental changes will probably occur long before the small measures that can be implemented by some building industries on a regional level have even the slightest effect. Meanwhile, the health of the planet in positive feedback. Any project that aims for a wise ecological dwelling on this planet needs to consider short-term sustainable measures in comparison with long-term enduring practices. Might schools of thoughts such as traditional architecture, Gaia theory, Earth System Science, deep ecology, eco-feminism, converge on a co-evolutionary partnership between the natural and the human?


2020 ◽  
Vol 8 (2) ◽  
pp. 243
Author(s):  
Abdul Manan ◽  
Muhazar Muhazar ◽  
Rahmad Syahputra ◽  
Cut Intan Salasiyah

This research studied the City Government’s endeavor of Banda Aceh to make the city as a civilized city model. Describing the efforts and constraints faced by the government, revealing responses of local citizens, and defining the present conditions of the city became the objective. A qualitative approach covering field observations, documents, and interviews, was applied and followed by data reduction, data display, and concluding. By involving related stakeholders, the new government duo headed by Aminullah Usman and Zainal Arifin has extended the Medium-term Development Plan to realize anew Long-term Development, Land Use, and Area Plan. Nevertheless, a lack of participation in the implementation of sharia appeared, less than optimal governance systems and uneven economic empowerment. Those generated varied responses from the lower, middle, and upper-class citizens. Therefore, to bring the glory of Banda Aceh, the duo has launched the concept of Banda Aceh the Brilliant City.


2020 ◽  
Vol 17 (2) ◽  
pp. 66-73
Author(s):  
R. D. Oktyabrskiy

The article is devoted to the justification of the need to reduce the population density in the residential development of cities. The analysis of vulnerability of the urban population from threats of emergency situations of peace and war time, and also an assessment of provision of the city by a road network is given. Proposals have been formulated to reduce the vulnerability of the urban population in the long term and to eliminate traffic congestion and congestion — jams.


2015 ◽  
Vol 12 (1) ◽  
pp. 1-12
Author(s):  
Sarah Hackett

Drawing upon a collection of oral history interviews, this paper offers an insight into entrepreneurial and residential patterns and behaviour amongst Turkish Muslims in the German city of Bremen. The academic literature has traditionally argued that Turkish migrants in Germany have been pushed into self-employment, low-quality housing and segregated neighbourhoods as a result of discrimination, and poor employment and housing opportunities. Yet the interviews reveal the extent to which Bremen’s Turkish Muslims’ performances and experiences have overwhelmingly been the consequences of personal choices and ambitions. For many of the city’s Turkish Muslim entrepreneurs, self-employment had been a long-term objective, and they have succeeded in establishing and running their businesses in the manner they choose with regards to location and clientele, for example. Similarly, interviewees stressed the way in which they were able to shape their housing experiences by opting which districts of the city to live in and by purchasing property. On the whole, they perceive their entrepreneurial and residential practices as both consequences and mediums of success, integration and a loyalty to the city of Bremen. The findings are contextualised within the wider debate regarding the long-term legacy of Germany’s post-war guest-worker system and its position as a “country of immigration”.


2019 ◽  
Vol 10 (1) ◽  
pp. 21-28
Author(s):  
Aniela Bălăcescu ◽  
Radu Șerban Zaharia

Abstract Tourist services represent a category of services in which the inseparability of production and consumption, the inability to be storable, the immateriality, and last but not least non-durability, induces in tourism management a number of peculiarities and difficulties. Under these circumstances the development of medium-term strategies involves long-term studies regarding on the one hand the developments and characteristics of the demand, and on the other hand the tourist potential analysis at regional and local level. Although in the past 20 years there has been tremendous growth of on-line booking made by household users, the tour operators agencies as well as those with sales activity continue to offer the specific services for a large number of tourists, that number, in the case of domestic tourism, increased by 1.6 times in case of the tour operators and by 4.44 times in case of the agencies with sales activity. At the same time, there have been changes in the preferences of tourists regarding their holiday destinations in Romania. Started on these considerations, paper based on a logistic model, examines the evolution of the probabilities and scores corresponding to the way the Romanian tourists spend their holidays on the types of tourism agencies, actions and tourist areas in Romania.


Author(s):  
Rodrigo Cueva ◽  
Guillem Rufian ◽  
Maria Gabriela Valdes

The use of Customer Relationship Managers to foster customers loyalty has become one of the most common business strategies in the past years.  However, CRM solutions do not fill the abundance of happily ever-after relationships that business needs, and each client’s perception is different in the buying process.  Therefore, the experience must be precise, in order to extend the loyalty period of a customer as much as possible. One of the economic sectors in which CRM’s have improved this experience is retailing, where the personalized attention to the customer is a key factor.  However, brick and mortar experiences are not enough to be aware in how environmental changes could affect the industry trends in the long term.  A base unified theoretical framework must be taken into consideration, in order to develop an adaptable model for constructing or implementing CRMs into companies. Thanks to this approximation, the information is complemented, and the outcome will increment the quality in any Marketing/Sales initiative. The goal of this article is to explore the different factors grouped by three main domains within the impact of service quality, from a consumer’s perspective, in both on-line and off-line retailing sector.  Secondly, we plan to go a step further and extract base guidelines about previous analysis for designing CRM’s solutions focused on the loyalty of the customers for a specific retailing sector and its product: Sports Running Shoes.


Author(s):  
Karen Ahlquist

This chapter charts how canonic repertories evolved in very different forms in New York City during the nineteenth century. The unstable succession of entrepreneurial touring troupes that visited the city adapted both repertory and individual pieces to the audience’s taste, from which there emerged a major theater, the Metropolitan Opera, offering a mix of German, Italian, and French works. The stable repertory in place there by 1910 resembles to a considerable extent that performed in the same theater today. Indeed, all of the twenty-five operas most often performed between 1883 and 2015 at the Metropolitan Opera were written before World War I. The repertory may seem haphazard in its diversity, but that very condition proved to be its strength in the long term. This chapter is paired with Benjamin Walton’s “Canons of real and imagined opera: Buenos Aires and Montevideo, 1810–1860.”


2021 ◽  
pp. 089020702110173
Author(s):  
Nadin Beckmann ◽  
Damian P Birney ◽  
Amirali Minbashian ◽  
Jens F Beckmann

The study aimed to investigate the status of within-person state variability in neuroticism and conscientiousness as individual differences constructs by exploring their (a) temporal stability, (b) cross-context consistency, (c) empirical links to selected antecedents, and (d) empirical links to longer term trait variability. Employing a sample of professionals ( N = 346) from Australian organisations, personality state data together with situation appraisals were collected using experience sampling methodology in field and repeatedly in lab-like settings. Data on personality traits, cognitive ability, and motivational mindsets were collected at baseline and after two years. Contingent (situation contingencies) and non-contingent (relative SD) state variability indices were relatively stable over time and across contexts. Only a small number of predictive effects of state variability were observed, and these differed across contexts. Cognitive ability appeared to be associated with state variability under lab-like conditions. There was limited evidence of links between short-term state and long-term trait variability, except for a small effect for neuroticism. Some evidence of positive manifold was found for non-contingent variability. Systematic efforts are required to further elucidate the complex pattern of results regarding the antecedents, correlates and outcomes of individual differences in state variability.


The Holocene ◽  
2021 ◽  
pp. 095968362199464
Author(s):  
Katarzyna Marcisz ◽  
Krzysztof Buczek ◽  
Mariusz Gałka ◽  
Włodzimierz Margielewski ◽  
Matthieu Mulot ◽  
...  

Landslide mountain fens formed in landslide depressions are dynamic environments as their development is disturbed by a number of factors, for example, landslides, slopewash, and surface run-off. These processes lead to the accumulation of mineral material and wood in peat. Disturbed peatlands are interesting archives of past environmental changes, but they may be challenging for providing biotic proxy-based quantitative reconstructions. Here we investigate long-term changes in testate amoeba communities from two landslide mountain fens – so far an overlooked habitat for testate amoeba investigations. Our results show that abundances of testate amoebae are extremely low in this type of peatlands, therefore not suitable for providing quantitative depth-to-water table reconstructions. However, frequent shifts of dominant testate amoeba species reflect dynamic lithological situation of the studied fens. We observed that high and stable mineral matter input into the peatlands was associated with high abundances of species producing agglutinated (xenosomic) as well as idiosomic shells which prevailed in the testate amoeba communities in both analyzed profiles. This is the first study that explores testate amoebae of landslide mountain fens in such detail, providing novel information about microbial communities of these ecosystems.


2020 ◽  
Vol 22 (Supplement_P) ◽  
pp. P56-P59
Author(s):  
Nick E J West ◽  
Wai-Fung Cheong ◽  
Els Boone ◽  
Neil E Moat

Abstract The global COVID-19 pandemic has led to unprecedented change throughout society.1 As the articles in this supplement outline, all segments of the broader cardiovascular community have been forced to adapt, to change models of care delivery, and to evolve and innovate in order to deliver optimal management for cardiovascular patients. The medtech/device industry has not been exempt from such change and has been forced to navigate direct and indirect COVID-associated disruption, with effects felt from supply chain logistics to the entire product lifecycle, from the running of clinical trials to new device approvals and managing training, proctoring and congresses in an increasingly-online world. This sea-change in circumstances itself has enforced the industry, in effect, to disrupt its own processes, models and activities. Whilst some of these changes may be temporary, many will endure for some time and some will doubtless become permanent; one thing is for sure: the healthcare ecosystem, including the medical device industry, will never look quite the same again. Although the pandemic has brought a short- to medium-term medical crisis to many countries, its role as a powerful disruptor cannot be underestimated, and may indeed prove to be a force for long-term good, given the accelerated innovation and rapid adaptation that it has cultivated.


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