The activity of sphingomyelin cycle enzymes and concentration of sphingomyelin degradation products in rat liver in dynamics of acute toxic hepatitis

2009 ◽  
Vol 3 (4) ◽  
pp. 382-385
Author(s):  
V. Yu. Serebrov ◽  
D. I. Kuzmenko ◽  
P. G. Burov ◽  
O. B. Sapugoltseva
Keyword(s):  
Rat Liver ◽  
Toxic Hepatitis ◽  
Degradation Products ◽  
Sphingomyelin Cycle ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic

scholarly journals Activity of enzymes of a sphingomyelin cycle and concentration of products of sphingomyelin degradation in the liver of rats in dynamics of the acute toxic hepatitis

2010 ◽  
Vol 56 (2) ◽  
pp. 283-289 ◽  
Author(s):  
V.Yu. Serebrov ◽  
D.I. Kuzmenko ◽  
P.G. Burov ◽  
O.B. Sapugoltseva
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Unsaturated Fatty Acids ◽  
Toxic Hepatitis ◽  
Control Level ◽  
Sphingomyelin Cycle ◽  
Sphingosine 1 Phosphate ◽  
Acute Toxic Hepatitis ◽  
Activity Of Enzymes ◽  
Acute Toxic

Activity of key enzymes of a sphingomyelin cycle and the maintenance of its components (sphingomyelin, ceramide and sphingosine-1-phosphate) have been studied in livers of rats in dynamics of the acute toxic hepatitis caused by hypodermic introduction of an oil solution of CCl4. Sphingomyelinase activity significally increased already on early terms and remained increased over the whole period of observation. Activity of ceramidase insignificantly differed from the control level. The levels of sphingomyelin and sphingosine-1-phosphate did not undergo marked changes while ceramidecontent significally increased. Thus, balance between liver content of ceramide (proapoptotic) and the sphingosine-1-phosphate, being the antiapoptotic factor, was shifted towards ceramide. In sphingomyelin molecules there was a significant decrease in the content of fatty acids С18:1 and С22:2, while in ceramide molecules and sphingosine-1-phosphate only fatty acid С22:2 changed. In spite of significant decrease in content of some unsaturated fatty acids, calculated unsaturation coefficients of the fatty acid component of the sphingomyelin cycle metabolites. Thus, our results together with literature data suggests involvement of ceramide-mediated apoptosis in the pathogenesis of acute toxic hepatitis. Elimination of damaged hepatocytes facilitates realization of repair processes and optimization of cellular community of a liver.

Action of sodium aurothiomalate in acute toxic hepatitis

1977 ◽  
Vol 83 (5) ◽  
pp. 637-640
Author(s):  
T. A. Korolenko ◽  
V. A. Shkurupii ◽  
V. M. Subbotin ◽  
G. S. Yakobson
Keyword(s):  
Toxic Hepatitis ◽  
Sodium Aurothiomalate ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic

Acute Toxic Hepatitis Induced by Herbal Medicine in Assam: A Pilot Study

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S567 ◽  
Author(s):  
Bhabadev Goswami ◽  
Preeti Sharma ◽  
Snigdha Saikia ◽  
Prajjalendra Barooah ◽  
Mallika Bhattacharyya ◽  
...  
Keyword(s):  
Pilot Study ◽  
Herbal Medicine ◽  
Toxic Hepatitis ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic

scholarly journals Acute Hepatitis after Ingestion of a Preparation of Chinese Skullcap and Black Catechu for Joint Pain

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Charilaos Papafragkakis ◽  
Mel A. Ona ◽  
Madhavi Reddy ◽  
Sury Anand
Keyword(s):  
Side Effects ◽  
Acute Hepatitis ◽  
Joint Pain ◽  
Toxic Hepatitis ◽  
Herbal Preparations ◽  
Wide Range ◽  
Herbal Medications ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic

Many herbal preparations are routinely used and have been occasionally associated with a wide range of side effects, from mild to severe. Chinese skullcap and black catechu are herbal medications commonly used for their hepatoprotective and other properties. We report a case of acute toxic hepatitis associated with ingestion of Chinese skullcap and black catechu in one preparation for the alleviation of joint pain.

Aloe vera-induced acute toxic hepatitis in a healthy young man

2006 ◽  
Vol 17 (8) ◽  
pp. 589 ◽  
Author(s):  
Ozkan Kanat ◽  
Ahmet Ozet ◽  
Selmin Ataergin
Keyword(s):  
Toxic Hepatitis ◽  
Aloe Vera ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic
Sign in / Sign up

Export Citation Format

Share Document