scholarly journals Response to: ‘Correspondence on ‘Blood-brain barrier leakage in systemic lupus erythematosus is associated with gray matter loss and cognitive impairment’’ by Pamuk and Hasni

2021 ◽  
pp. annrheumdis-2021-220057
Author(s):  
Lyna Kamintsky ◽  
Steven D Beyea ◽  
John D Fisk ◽  
Javeria A Hashmi ◽  
Antonina Omisade ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cognitive Impairment ◽  
Blood Brain Barrier ◽  
Gray Matter ◽  
Lupus Erythematosus ◽  
Brain Barrier ◽  
Systemic Lupus ◽  
Blood Brain ◽  
Gray Matter Loss

Blood-brain barrier leakage in systemic lupus erythematosus is associated with gray matter loss and cognitive impairment

2020 ◽  
Vol 79 (12) ◽  
pp. 1580-1587
Author(s):  
Lyna Kamintsky ◽  
Steven D Beyea ◽  
John D Fisk ◽  
Javeria A Hashmi ◽  
Antonina Omisade ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Blood Brain Barrier ◽  
Lupus Erythematosus ◽  
Brain Volume ◽  
Brain Barrier ◽  
Systemic Lupus ◽  
Blood Brain ◽  
Gray Matter Loss

ObjectivesTo examine the association between blood-brain barrier (BBB) integrity, brain volume and cognitive dysfunction in adult patients with systemic lupus erythematosus (SLE).MethodsA total of 65 ambulatory patients with SLE and 9 healthy controls underwent dynamic contrast-enhanced MRI scanning, for quantitative assessment of BBB permeability. Volumetric data were extracted using the VolBrain pipeline. Global cognitive function was evaluated using a screening battery consisting of tasks falling into five broad cognitive domains, and was compared between patients with normal versus extensive BBB leakage.ResultsPatients with SLE had significantly higher levels of BBB leakage compared with controls (p=0.04). Extensive BBB leakage (affecting over >9% of brain volume) was identified only in patients with SLE (16/65; 24.6%), who also had smaller right and left cerebral grey matter volumes compared with controls (p=0.04). Extensive BBB leakage was associated with lower global cognitive scores (p=0.02), and with the presence of impairment on one or more cognitive tasks (p=0.01).ConclusionOur findings provide evidence for a link between extensive BBB leakage and changes in both brain structure and cognitive function in patients with SLE. Future studies should investigate the mechanisms underlying BBB-mediated cognitive impairment, validate the diagnostic utility of BBB imaging, and determine the potential of targeting the BBB as a therapeutic strategy in patients with SLE.

scholarly journals C5a alters blood-brain barrier integrity in a humanin vitromodel of systemic lupus erythematosus

Immunology ◽  
2015 ◽  
Vol 146 (1) ◽  
pp. 130-143 ◽  
Author(s):  
Supriya D. Mahajan ◽  
Neil U. Parikh ◽  
Trent M. Woodruff ◽  
James N. Jarvis ◽  
Molly Lopez ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Blood Brain Barrier ◽  
Lupus Erythematosus ◽  
Brain Barrier ◽  
Systemic Lupus ◽  
Barrier Integrity ◽  
Blood Brain ◽  
Blood Brain Barrier Integrity

The blood-brain barrier in systemic lupus erythematosus

Lupus ◽  
2003 ◽  
Vol 12 (12) ◽  
pp. 908-915 ◽  
Author(s):  
N J Abbott ◽  
L LF Mendonça ◽  
D EM Dolman
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Blood Brain Barrier ◽  
Lupus Erythematosus ◽  
Brain Barrier ◽  
Systemic Lupus ◽  
Blood Brain
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