scholarly journals Growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 Pelotas birth cohort

BMJ Open ◽  
2018 ◽  
Vol 8 (1) ◽  
pp. e019164
Author(s):  
Romina Buffarini ◽  
María Clara Restrepo-Méndez ◽  
Vera Maria Silveira ◽  
Helen D Gonçalves ◽  
Isabel O Oliveira ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Weight Gain ◽  
Birth Cohort ◽  
Hdl Cholesterol ◽  
Population Based ◽  
Childhood And Adolescence ◽  
Rapid Weight Gain ◽  
Reactive Protein ◽  
Height Gain ◽  
First Year Of Life

ObjectiveTo evaluate the association between growth trajectories from birth to adolescence and cardiovascular risk marker levels at age 18 years in a population-based cohort. In order to disentangle the effect of weight gain from that of height gain, growth was analysed using conditional weight relative to linear growth (CWh) and conditional length/height (CH).DesignProspective study.Setting1993 Pelotas birth cohort, Southern Brazil.ParticipantsIndividuals who have been followed up from birth to adolescence (at birth, 1, 4, 11, 15 and 18 years).Primary outcome measuresC-reactive protein (CRP), total cholesterol (TC), LDL cholesterol (LDL-C), HDL-cholesterol (HDL-C), triglycerides (TGL), systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI) and waist circumference (WC).ResultsIn both sexes, greater CWh at 1 year was positively associated with BMI and WC, whereas greater CWh at most age periods in childhood and adolescence predicted higher CRP, TC, LDL-C, TGL, SBP, DBP, BMI and WC levels, as well as lower HDL-C level. Higher CH during infancy and childhood was positively related with SBP in boys and girls, and with BMI and WC only in boys.ConclusionOur study shows that rapid weight gain from 1 year onwards is positively associated with several markers of cardiovascular risk at 18 years. Overall, our results for the first year of life add evidence to the ‘first 1000 days initiative’ suggesting that prevention of excessive weight gain in childhood might be important in reducing subsequent cardiovascular risk.

scholarly journals Delivery Mode, Duration of Labor, and Cord Blood Adiponectin, Leptin, and C-Reactive Protein: Results of the Population-Based Ulm Birth Cohort Studies

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0149918 ◽  
Author(s):  
Chad A. Logan ◽  
Larissa Thiel ◽  
Rebecca Bornemann ◽  
Wolfgang Koenig ◽  
Frank Reister ◽  
...  
Keyword(s):  
Cohort Studies ◽  
Cord Blood ◽  
Birth Cohort ◽  
Population Based ◽  
Delivery Mode ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Association between childhood infection, serum inflammatory markers and intelligence: findings from a population-based prospective birth cohort study

2017 ◽  
Vol 146 (2) ◽  
pp. 256-264 ◽  
Author(s):  
N. MACKINNON ◽  
S. ZAMMIT ◽  
G. LEWIS ◽  
P. B. JONES ◽  
G. M. KHANDAKER
Keyword(s):  
Birth Cohort ◽  
Inflammatory Markers ◽  
Intellectual Development ◽  
Inflammatory Marker ◽  
Population Based ◽  
Birth Cohort Study ◽  
Reactive Protein ◽  
Parents And Children ◽  
High Infection ◽  
Prospective Birth Cohort

SUMMARYA link between infection, inflammation, neurodevelopment and adult illnesses has been proposed. The objective of this study was to examine the association between infection burden during childhood – a critical period of development for the immune and nervous systems – and subsequent systemic inflammatory markers and general intelligence. In the Avon Longitudinal Study of Parents and Children, a prospective birth cohort in England, we examined the association of exposure to infections during childhood, assessed at seven follow-ups between age 1·5 and 7·5 years, with subsequent: (1) serum interleukin 6 and C-reactive protein (CRP) levels at age 9; (2) intelligence quotient (IQ) at age 8. We also examined the relationship between inflammatory markers and IQ. Very high infection burden (90+ percentile) was associated with higher CRP levels, but this relationship was explained by body mass index (adjusted odds ratio (OR) 1·19; 95% confidence interval (CI) 0·95–1·50), maternal occupation (adjusted OR 1·23; 95% CI 0·98–1·55) and atopic disorders (adjusted OR 1·24; 95% CI 0·98–1·55). Higher CRP levels were associated with lower IQ; adjusted β = −0·79 (95% CI −1·31 to −0·27); P = 0·003. There was no strong evidence for an association between infection and IQ. The findings indicate that childhood infections do not have an independent, lasting effect on circulating inflammatory marker levels subsequently in childhood; however, elevated inflammatory markers may be harmful for intellectual development/function.

scholarly journals Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium

The Lancet ◽  
2019 ◽  
Vol 394 (10215) ◽  
pp. 2173-2183 ◽  
Author(s):  
Fabian J Brunner ◽  
Christoph Waldeyer ◽  
Francisco Ojeda ◽  
Veikko Salomaa ◽  
Frank Kee ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Risk Stratification ◽  
Hdl Cholesterol ◽  
Population Based ◽  
Cardiovascular Risk Stratification

scholarly journals Acid-suppressive medications in the first year of life and risk of childhood asthma: a population-based birth cohort study

2020 ◽  
Vol 56 (5) ◽  
pp. 2000197 ◽  
Author(s):  
Claudio Barbiellini Amidei ◽  
Rosanna Comoretto ◽  
Loris Zanier ◽  
Daniele Donà ◽  
Anna Cantarutti ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Childhood Asthma ◽  
Population Based ◽  
Birth Cohort Study ◽  
First Year ◽  
First Year Of Life

scholarly journals Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene

2011 ◽  
Vol 165 (4) ◽  
pp. 571-577 ◽  
Author(s):  
Bernard M Y Cheung ◽  
Kwok Leung Ong ◽  
Annette W K Tso ◽  
Raymond Y H Leung ◽  
Stacey S Cherny ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Plasma Levels ◽  
Population Based ◽  
Minor Allele ◽  
Nucleotide Polymorphisms ◽  
Gene Encoding ◽  
Single Nucleotide ◽  
Reactive Protein ◽  
Cardiovascular Risk Prediction ◽  
Design And Methods

ObjectiveAdrenomedullin (ADM) plays an important role in inflammation and is a marker of future cardiovascular events. We studied common single nucleotide polymorphisms (SNPs) in the gene encoding ADM and their relationship with the plasma levels of ADM and other inflammatory markers.Design and methodsPlasma ADM, interleukin 6 (IL6), fibrinogen, and C-reactive protein (CRP) were measured in 476 subjects from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study-2. Four tag SNPs in ADM were genotyped.ResultsPlasma ADM level increased with decreasing plasma IL6 level (β=−0.116, P=0.014). Plasma ADM level was not related to plasma levels of CRP and fibrinogen, and other clinical characteristics, except age (P=0.049). The four SNPs, rs3814700, rs11042725, rs34354539, and rs4910118, had minor allele frequencies of 31.1, 28.7, 33.8, and 23.4% respectively. Carriers of the minor allele of rs4910118 had a mean plasma ADM level that was 10.5% (95% confidential interval: 2.5–17.8%) lower than the non-carriers (β=−0.115, P=0.011). Haplotype analysis revealed a similar significant association with plasma ADM (P=0.040). In multivariate analysis, the presence of the minor allele of rs4910118, but not plasma IL6, was independently associated with plasma ADM (P=0.010).ConclusionPlasma ADM correlates with plasma IL6 level, consistent with its role in inflammation. It is related to an SNP common in Chinese, independent of other covariates. ADM genotype should be included in future studies of cardiovascular risk prediction.

scholarly journals Relation between Birth Weight, Growth, and Subclinical Atherosclerosis in Adulthood

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Maria Helena Valente ◽  
Filumena Maria da Silva Gomes ◽  
Isabela Judith Martins Benseñor ◽  
Alexandra Valéria Maria Brentani ◽  
Ana Maria de Ulhôa Escobar ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Weight Gain ◽  
Subclinical Atherosclerosis ◽  
Hdl Cholesterol ◽  
Intima Media Thickness ◽  
First Year ◽  
Increased Risk ◽  
Low Hdl ◽  
Right Lobe ◽  
First Year Of Life

Background and Objectives.Adverse conditions in the prenatal environment and in the first years of life are independently associated with increased risk for cardiovascular disease. This paper aims to study the relation between birthweight, growth in the first year of life, and subclinical atherosclerosis in adults.Methods.88 adults aged between 20 and 31 were submitted to sociodemographic qualities, anthropometric data, blood pressure measurements, metabolic profile, and evaluation of subclinical atherosclerosis.Results.Birthweight <2,500 grams (g) was negatively correlated with (a) increased waist-to-hip ratio (WHR), according to regression coefficient (RC) equal to −0.323, 95% CI [−0.571, −0.075]P<0.05; (b) diastolic blood pressure (RC = −4.744, 95% CI [−9.017, −0.470]P<0.05); (c) low HDL-cholesterol (RC = −0.272, 95% CI [−0.516, −0.029]P<0.05); (d) frequency of intima-media thickness (IMT) of left carotid >75th percentile (RC = −0.242, 95% CI [−0.476, −0.008]P<0.05). Birthweight >3,500 g was associated with (a) BMI >25.0 kg/m2, (RC = 0.317, 95% CI [0.782, 0.557]P<0.05); (b) increased waist circumference (RC = 0.284, 95% CI [0.054, 0.513]P<0.05); (c) elevated WHR (RC = 0.280, 95% CI [0.054, 0.505]P<0.05); (d) minimum subcutaneous adipose tissue (SAT) (RC = 4.354, 95% CI [0.821, 7.888]P<0.05); (e) maximum SAT (RC = 7.095, 95% CI [0.608, 13.583]P<0.05); (f) right lobe of the liver side (RC = 6.896, 95% CI [1.946, 11.847]P<0.001); (g) frequency’s right lobe of the liver >75th percentile (RC = 0.361, 95% CI [0.169, 0.552]P<0.001). Weight gain in the first year of life was inversely correlated with (a) mean IMT of left carotid (RC = −0.046, 95% CI [−0.086, −0.006]P<0.05; (b) frequency IMT of left carotid >75th percentile (RC = −0.253, 95% CI [−0.487, −0.018]P<0.05); (c) mean IMT (RC = −0.038, 95% CI [0.073, −0.002]P<0.05); (d) the frequency of the mean IMT >75th percentile (RC = −0.241, 95% CI [−0.442, −0.041]P<0.05).Conclusions.Adults birthweight <2,500 g and >3,500 g and with insufficient weight gain in the first year of life have showed different metabolic phenotypes, but all of them were related to subclinical atherosclerosis.

CHILDHOOD AND ADOLESCENCE PREDICTORS OF PSYCHOSIS IN THE GENERAL POPULATION -BASED NORTHERN FINLAND 1986 BIRTH COHORT

2010 ◽  
Vol 117 (2-3) ◽  
pp. 172-173
Author(s):  
Pirjo H. Mäki ◽  
Jouko Miettunen ◽  
Marika Kaakinen ◽  
Irma K. Moilanen ◽  
Anja Taanila ◽  
...  
Keyword(s):  
General Population ◽  
Birth Cohort ◽  
Population Based ◽  
Childhood And Adolescence
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