scholarly journals A series of evidence-based drug therapy letters improved prescribing behaviour

2005 ◽  
Vol 10 (3) ◽  
pp. 91-91 ◽  
Author(s):  
J. F Steiner
Keyword(s):  
Drug Therapy ◽  
Evidence Based ◽  
Prescribing Behaviour

Pharmacogenomics and Precision Psychiatry

2018 ◽  
pp. 96-102
Author(s):  
Julia C. Stingl ◽  
Gonzalo Laje
Keyword(s):  
Genetic Variation ◽  
Clinical Practice ◽  
Drug Therapy ◽  
Mechanisms Of Action ◽  
Molecular Medicine ◽  
Evidence Based ◽  
Broad Definition ◽  
Clinical Syndromes ◽  
Definition Of ◽  
Future Work

Molecular medicine has opened new possibilities of personalized approaches in drug therapy. The development of evidence-based pharmacogenetic guidelines to steer therapy has slowly entered the field of psychiatric therapeutics. Some of the reasons behind the limited progress in psychiatric pharmacogenomics include the broad definition of clinical syndromes, limited knowledge of psychiatric pathophysiology, and limited understanding of psychotropics’ mechanisms of action. Pharmacogenomic markers have been reported for both pharmacodynamic and pharmacokinetic genes. However, only genetic variation in pharmacokinetic genes has shown to be helpful in clinical practice. There is little consensus as to when and if pharmacogenetic tests should be used in psychiatry. There are limited evidence-based dosing guidelines available for actionable gene–drug pairs. Future work in psychiatry may deepen our understanding of the biological underpinnings of psychiatric syndromes and provide the potential for individual tailored therapies.

scholarly journals 1. Evidence-based Drug Therapy

2009 ◽  
Vol 98 (2) ◽  
pp. 299-305
Author(s):  
Hideki Okayama ◽  
Jitsuo Higaki
Keyword(s):  
Drug Therapy ◽  
Evidence Based

The Refractory Patient—Managing Diabetes by the Ear

2015 ◽  
Vol 11 (01) ◽  
pp. 32 ◽  
Author(s):  
Sanjay Kalra ◽  
Yashdeep Gupta ◽  
◽  
Keyword(s):  
Drug Therapy ◽  
Pharmacological Therapy ◽  
Evidence Based ◽  
History Taking ◽  
Diabetes Therapy ◽  
Therapeutic Patient Education ◽  
Bidirectional Communication ◽  
Empathic Listening ◽  
Specialist Practice ◽  
Control Diabetes

Refractory, or ‘difficult to control,’ diabetes is a commonly encountered condition in specialist practice. This editorial describes the characteristics of people with diabetes who are unable to achieve optimal glycemic control, despite aggressive drug therapy. It reflects upon the importance of bidirectional communication between patient and physician, and highlights the need for systematic history taking, empathic listening, and therapeutic patient education. The editors call for practicing ‘diabetes therapy by the ear,’ in conjunction with evidence-based pharmacological therapy, to help reduce the prevalence of refractory diabetes.

Developing a paediatric drug formulary for the Netherlands

2016 ◽  
Vol 102 (4) ◽  
pp. 357-361 ◽  
Author(s):  
Tjitske M van der Zanden ◽  
Saskia N de Wildt ◽  
Yves Liem ◽  
Martin Offringa ◽  
Matthijs de Hoog
Keyword(s):  
Drug Therapy ◽  
Drug Use ◽  
The Netherlands ◽  
Evidence Based ◽  
Drug Formulary ◽  
Concerted Effort ◽  
Off Label ◽  
Registration Data ◽  
Current Content ◽  
Professional Guidelines

As many drugs in paediatrics are used off-label, prescribers face a lack of evidence-based dosing guidelines. A Dutch framework was developed to provide dosing guidelines based on best available evidence from registration data, investigator-initiated research, professional guidelines, clinical experience and consensus. This has clarified the scientific grounds of drug use for children and encouraged uniformity in prescribing habits in the Netherlands. The developed framework and the current content of the Dutch Paediatric Formulary could be used as basis for similar initiatives worldwide, preferably in a concerted effort to ultimately provide children with effective and safe drug therapy.

scholarly journals The role of chondroprotectors in the pharmacological treatment of osteoarthritis

2019 ◽  
pp. 100-109
Author(s):  
L. K. Peshekhonova ◽  
P. A. Krasyukov
Keyword(s):  
Drug Therapy ◽  
Musculoskeletal System ◽  
Evidence Based Medicine ◽  
Cartilage Tissue ◽  
Evidence Based ◽  
Third Generation ◽  
Based Medicine ◽  
Vitro Effect

The article is devoted to third-generation slow-modifying chondroprotective drug therapy including Alflutop. The evidence-based  medicine showed and substantiated in vitro effect of the drug on the pathogenetic processes in the cartilage tissue, its promotion  of the inflammation regression in the musculoskeletal system. The authors present a series of clinical studies of top osteoarthritis doctors, which showed that Alflutop had an anti-inflammatory, chondroprotective, analgesic effect, and that the administration of  the drug allowed patients to reduce the doses of NSAIDs, and it could be used in patients with comorbid diseases. 

scholarly journals Antibiotics and its altered pharmacokinetics in the pediatric population : An evidence-based review

2020 ◽  
Vol 11 (1) ◽  
pp. 858-864
Author(s):  
Keerthana Chandrasekar ◽  
Diya C ◽  
Arun KP
Keyword(s):  
Drug Therapy ◽  
Pediatric Patients ◽  
Pediatric Population ◽  
Therapeutic Agents ◽  
Early Age ◽  
Antibiotic Prescribing ◽  
Evidence Based ◽  
The Difference ◽  
Altered Pharmacokinetic ◽  
Time Required

A better understanding of altered pharmacokinetic variables in the pediatric population is important to improve both the safety and efficacy of drug therapy. Even though pediatric patients are now considered as a special population for drug therapy, it should not give us the wrong idea of considering them like mini-adults. The difference in their pharmacokinetics may be attributed to the radical anatomical and physiological changes that happen with age. Antimicrobials are one of the most prescribed therapeutic agents, and they are used in the treatment of numerous infections. Children are always susceptible to various infections, which often results in their exposure to a wide variety of antibiotics at such an early age. Recent studies showed higher rates of antibiotic prescribing in the pediatric population. The pediatric population requires more attention when prescribing antibiotics due to the increased probability of serious adverse effects, the time required for the complete development of the organs, and augmented drug resistance.

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