scholarly journals Effect of periodic letters on evidence-based drug therapy on prescribing behaviour: a randomized trial

2004 ◽  
Vol 171 (9) ◽  
pp. 1057-1061 ◽  
Author(s):  
C. R. Dormuth
2015 ◽  
Vol 11 (1) ◽  
Author(s):  
Jennifer D. Allen ◽  
Maria Idalí Torres ◽  
Laura S. Tom ◽  
Bryan Leyva ◽  
Ana V. Galeas ◽  
...  

2018 ◽  
pp. 96-102
Author(s):  
Julia C. Stingl ◽  
Gonzalo Laje

Molecular medicine has opened new possibilities of personalized approaches in drug therapy. The development of evidence-based pharmacogenetic guidelines to steer therapy has slowly entered the field of psychiatric therapeutics. Some of the reasons behind the limited progress in psychiatric pharmacogenomics include the broad definition of clinical syndromes, limited knowledge of psychiatric pathophysiology, and limited understanding of psychotropics’ mechanisms of action. Pharmacogenomic markers have been reported for both pharmacodynamic and pharmacokinetic genes. However, only genetic variation in pharmacokinetic genes has shown to be helpful in clinical practice. There is little consensus as to when and if pharmacogenetic tests should be used in psychiatry. There are limited evidence-based dosing guidelines available for actionable gene–drug pairs. Future work in psychiatry may deepen our understanding of the biological underpinnings of psychiatric syndromes and provide the potential for individual tailored therapies.


2009 ◽  
Vol 98 (2) ◽  
pp. 299-305
Author(s):  
Hideki Okayama ◽  
Jitsuo Higaki
Keyword(s):  

2015 ◽  
Vol 11 (01) ◽  
pp. 32 ◽  
Author(s):  
Sanjay Kalra ◽  
Yashdeep Gupta ◽  
◽  

Refractory, or ‘difficult to control,’ diabetes is a commonly encountered condition in specialist practice. This editorial describes the characteristics of people with diabetes who are unable to achieve optimal glycemic control, despite aggressive drug therapy. It reflects upon the importance of bidirectional communication between patient and physician, and highlights the need for systematic history taking, empathic listening, and therapeutic patient education. The editors call for practicing ‘diabetes therapy by the ear,’ in conjunction with evidence-based pharmacological therapy, to help reduce the prevalence of refractory diabetes.


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