Maternal obesity, pregnancy weight gain, and birth weight and risk of colorectal cancer

Gut ◽  
2021 ◽  
pp. gutjnl-2021-325001
Author(s):  
Caitlin C Murphy ◽  
Piera M Cirillo ◽  
Nickilou Y Krigbaum ◽  
Amit G Singal ◽  
MinJae Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Weight Gain ◽  
Birth Weight ◽  
Maternal Obesity ◽  
Proportional Hazards ◽  
Incidence Rates ◽  
Cox Proportional Hazards ◽  
Pregnancy Weight Gain ◽  
Early Weight Gain ◽  
Pregnancy Weight

ObjectiveColorectal cancer (CRC) is a leading cause of cancer-related death worldwide. Obesity is a well-established risk factor for CRC, and fetal or developmental origins of obesity may underlie its effect on cancer in adulthood. We examined associations of maternal obesity, pregnancy weight gain, and birth weight and CRC in adult offspring.DesignThe Child Health and Development Studies is a prospective cohort of women receiving prenatal care between 1959 and 1966 in Oakland, California (N=18 751 live births among 14 507 mothers). Clinical information was abstracted from mothers’ medical records 6 months prior to pregnancy through delivery. Diagnoses of CRC in adult (age ≥18 years) offspring were ascertained through 2019 by linkage with the California Cancer Registry. We used Cox proportional hazards models to estimate adjusted HR (aHR); we examined effect measure modification using single-referent models to estimate the relative excess risk due to interaction (RERI).Results68 offspring were diagnosed with CRC over 738 048 person-years of follow-up, and half (48.5%) were diagnosed younger than age 50 years. Maternal obesity (≥30 kg/m2) increased the risk of CRC in offspring (aHR 2.51, 95% CI 1.05 to 6.02). Total weight gain modified the association of rate of early weight gain (RERI −4.37, 95% CI −9.49 to 0.76), suggesting discordant growth from early to late pregnancy increases risk. There was an elevated association with birth weight (≥4000 g: aHR 1.95, 95% CI 0.8 to 4.38).ConclusionOur results suggest that in utero events are important risk factors for CRC and may contribute to increasing incidence rates in younger adults.

scholarly journals Early Pregnancy Weight Gain Exerts the Strongest Effect on Birth Weight, Posing a Critical Time to Prevent Childhood Obesity

Obesity ◽  
2017 ◽  
Vol 25 (9) ◽  
pp. 1569-1576 ◽  
Author(s):  
Nicholas T. Broskey ◽  
Peng Wang ◽  
Nan Li ◽  
Junhong Leng ◽  
Weiqin Li ◽  
...  
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Childhood Obesity ◽  
Early Pregnancy ◽  
Critical Time ◽  
Pregnancy Weight Gain ◽  
Pregnancy Weight

Fetal Subcutaneous Fat by 3D Water-Fat MRI is Independent of Maternal Obesity, Excessive Pregnancy Weight Gain and Diabetes.

2018 ◽  
Vol 40 (6) ◽  
pp. 839
Author(s):  
Tianna Koreman ◽  
Stephanie A. Giza ◽  
Genevieve Eastabrook ◽  
Debbie Penava ◽  
Charles A. McKenzie ◽  
...  
Keyword(s):  
Weight Gain ◽  
Maternal Obesity ◽  
Subcutaneous Fat ◽  
Pregnancy Weight Gain ◽  
Pregnancy Weight

scholarly journals Decreased risk of colorectal cancer among patients with type 2 diabetes receiving Chinese herbal medicine: a population-based cohort study

2020 ◽  
Vol 8 (1) ◽  
pp. e000732
Author(s):  
Jing-Siang Jhang ◽  
Hanoch Livneh ◽  
Shu-Yi Yang ◽  
Hui-Ju Huang ◽  
Michael W Y Chan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Type 2 Diabetes ◽  
Cohort Study ◽  
Proportional Hazards ◽  
Herbal Medicines ◽  
Incidence Rates ◽  
Cox Proportional Hazards ◽  
Research Database ◽  
Chinese Herbal

ObjectivesPatients with type 2 diabetes have a higher risk of colorectal cancer (CRC), but whether Chinese herbal medicines (CHMs) can reduce this risk is unknown. This study investigated the effect that CHMs have on CRC risk in patients with type 2 diabetes.Research design and methodsThis cohort study used the Taiwanese National Health Insurance Research Database to identify 54 744 patients, newly diagnosed with type 2 diabetes, aged 20–70 years, who were receiving treatment between 1998 and 2007. From this sample, we randomly selected 14 940 CHMs users and 14 940 non-CHMs users, using propensity scores matching. All were followed through 2012 to record CRC incidence. Cox proportional hazards regression was used to compute the hazard ratio (HR) of CRC by CHMs use.ResultsDuring follow-up, 235 CHMs users and 375 non-CHMs users developed CRC, incidence rates of 1.73% and 2.47% per 1000 person-years, respectively. CHM users had a significantly reduced risk of CRC compared with non-CHM users (adjusted HR=0.71; 95% CI 0.60 to 0.84). The greatest effect was in those receiving CHMs for more than 1 year. Huang-Qin, Xue-Fu-Zhu-Yu-Tang, Shu-Jing-Huo-Xue-Tang, Liu-Wei-Di-Huang-Wan, Ji-Sheng-Shen-Qi-Wan, Gan-Lu-Yin, Shao-Yao-Gan-Cao-Tang and Ban-Xia-Xie-Xin-Tang were significantly associated with lower risk of CRC.ConclusionIntegrating CHMs into the clinical management of patients with type 2 diabetes may be beneficial in reducing the risk of CRC.

scholarly journals Social factors and pregnancy weight gain in relation to infant birth weight: a study in public health centers in Rasht, Iran

2005 ◽  
Vol 59 (10) ◽  
pp. 1208-1212 ◽  
Author(s):  
M Maddah ◽  
M Karandish ◽  
B Mohammadpour-Ahranjani ◽  
T R Neyestani ◽  
R Vafa ◽  
...  
Keyword(s):  
Public Health ◽  
Weight Gain ◽  
Birth Weight ◽  
Social Factors ◽  
Health Centers ◽  
Pregnancy Weight Gain ◽  
Pregnancy Weight ◽  
Infant Birth

scholarly journals Short Inter-pregnancy Intervals, Parity, Excessive Pregnancy Weight Gain and Risk of Maternal Obesity

2013 ◽  
Vol 18 (3) ◽  
pp. 554-562 ◽  
Author(s):  
Esa M. Davis ◽  
Denise C. Babineau ◽  
Xuelei Wang ◽  
Stephen Zyzanski ◽  
Barbara Abrams ◽  
...  
Keyword(s):  
Weight Gain ◽  
Maternal Obesity ◽  
Pregnancy Weight Gain ◽  
Pregnancy Intervals ◽  
Pregnancy Weight

scholarly journals Maternal anthropometry and weight gain as risk factors for low birth weight in singleton uncomplicated pregnancies

2017 ◽  
Vol 1 (1) ◽  
pp. 6
Author(s):  
Rafia Bano
Keyword(s):  
Risk Factors ◽  
Saudi Arabia ◽  
Weight Gain ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnancy Outcomes ◽  
Maternal Body Mass Index ◽  
Pregnancy Weight Gain ◽  
Maternity Hospitals ◽  
Pregnancy Weight

Objectives: The present cross sectional study was done to investigate the maternal anthropometry and weight gain in relation to pregnancy outcomes of mothers in Hail city of Saudi Arabia. Methods: The study was carried out in two maternity hospitals of Hail, Saudi Arabia. Sample size of 522 mothers who delivered single live baby without any congenital abnormality were selected to be included in the present study. Mother’s and infant’s anthropometric measurements were taken with standard  techniques. Hemoglobin, blood sugar and blood pressure were recorded using   electronic devices. Information regarding the demographic characteristics, health status of mothers, antenatal checkups and health related habits were accessed through structured questionnaire. Data was entered and analyzed through the Statistical Package for Social Sciences (SPSS) 17.0 Software. Odds Ratios, Means, Pearson’s correlation, Analysis of Variance were done to find out the risk factors associated with poor pregnancy outcome. Results: The mean birth weight of the infants was 3.16 kg ranging from 1.7 kg to 5.4 kg. Male babies tend to be heavier, whereas 100% of the very low birth weight deliveries were only females. Other factors like maternal Body mass Index before pregnancy, Weight gain in pregnancy, Maternal anemia, presence of chronic illnesses like diabetes, Hypertension and hypo/hyperthyroidism had    effected the birth weight of newborn infants. Conclusion: The present study provides some useful data to promote healthy pregnancy outcomes. Maternal factors like  nutritional status, poor pregnancy weight gain and unhealthy obstetric history are found to be the major risk factors.

scholarly journals Association of Pregnancy Weight Gain with Infant Birth Weight and Postpartum Weight Retention

2005 ◽  
Vol 3 (4) ◽  
pp. 144-156 ◽  
Author(s):  
Gigliola Baruffi ◽  
Charles Hardy ◽  
Carol Waslien ◽  
Sue Uyehara ◽  
Dmitry Krupitsky ◽  
...  
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Ethnic Differences ◽  
Average Weight ◽  
Weight Retention ◽  
Pregnancy Weight Gain ◽  
Prepregnancy Bmi ◽  
Postpartum Weight ◽  
Pregnancy Weight ◽  
Infant Birth

Purpose: To investigate weight gain during pregnancy and its association with birth weight and weight retention postpartum (PP) among women of different ethnic backgrounds. Methods: Cross-sectional study of 5,863 women participating in the Hawai`i Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) in 1997 and 1998. Postpartum weight and height were measured by WIC staff, weight gain during pregnancy and infant birth weight were self-reported. Ethnicity was also selfreported. The Institute of Medicine guidelines for pregnancy weight gain in relation to levels of prepregnancy body mass index (BMI) were followed. The analysis included bivariate tests of association between prepregnancy BMI, pregnancy weight gain, PP weight retention, infant birth weight and ethnicity. Multivariable analysis was conducted to estimate the independent association of the study variables with PP weight retention, birth weight, and ethnicity. SAS was used to analyze the data. Results: The largest ethnic groups were Hawaiian (29.9%), Caucasian (27.2%), and Filipino (19.8%). Asians, Blacks, Samoans, and Other represented smaller percentages. Thirty percent of women were overweight or obese before pregnancy. There were significant ethnic differences in prepregnancy BMI. Samoans had the highest mean prepregnancy BMI (29.7). Filipinos had the lowest mean prepregnancy BMI (22.5). There were significant differences in pregnancy weight gain. Samoans had the highest mean weight gain (37.3 lbs). Asians had the lowest mean weight gain (29.1bs). Almost one half of women (48.1%) gained more than the IOM recommended pregnancy weight. The average weight retention was 9.4 lbs at five to six months postpartum, and 7.4 lbs after eight months postpartum. There were significant ethnic differences in weight retention with Samoans having the largest average weight retention (17.5 lbs) and Asians the lowest (9.6 lbs). Infant birth weight differed significantly by ethnicity. Birth weight was significantly associated with prepregnancy BMI and pregnancy weight gain. Conclusions: In spite of large racial/ethnic differences, on the average there was almost a two-thirds pound adjusted PP weight retention for each pound of weight gained during pregnancy. Our study suggests a need for integrated women’s health services to include nutritional support during the pre and post conceptual period. Findings of this study will provide guidance in the development of culturally sensitive interventions and counseling.

Sign in / Sign up

Export Citation Format

Share Document