Uterine serous papillary carcinoma: Histopathologic changes within the female genital tract

2001 ◽  
Vol 11 (4) ◽  
pp. 283-289 ◽  
Author(s):  
L. B. Jordan ◽  
M. Abdul-Kader ◽  
A. Al-Nafussi
Keyword(s):  
Papillary Carcinoma ◽  
Fallopian Tube ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Serous Carcinoma ◽  
Tumor Spread ◽  
Histopathologic Changes ◽  
Serous Papillary Carcinoma ◽  
Female Genital

Abstract.Jordan LB, Abdul-Kader M, Al-Nafussi A. Uterine serous papillary carcinoma: Histopathologic changes within the female genital tract.The histopathologic features of 25 patients with uterine serous papillary carcinoma (USPC) were presented, with particular emphasis on the changes seen in the remaining müllerian epithelium. The mean age at presentation was 68.9 years; 52% of patients were stage III at the time of presentation and 40% died of their disease within 24 months of diagnosis. Histologic assessment revealed: 1) pure serous carcinoma in 56% of patients and mixed differentiation of serous and endometrioid in the remainder; 2) malignant epithelium reminiscent of that of USPC and akin to carcinoma in situ, frequently seen in the remaining endometrium, cervix, and, less commonly, the fallopian tube; 3) residual endometrium that, when identified (11/25 cases), was atrophic in all cases; 4) various types of cervical involvement in 17 cases (68%) ; 5) tumor within the fallopian tube in three cases (12%); and 6) carcinoma with in situ-like features in five cases (20%). In conclusion, it appears that USPC is frequently associated with malignant epithelial changes (as with carcinoma in situ) in the remaining müllerian epithelium. This finding suggests either a field change or, more likely, a transepithelial tumor spread. The latter theory is preferable, because this type of spread is frequently seen on serosal surfaces in cases of serous ovarian carcinoma. Uterine serous papillary carcinoma is, therefore, biologically more akin to its ovarian counterpart.

XXXVII.—Mendelian Action on Differentiated Sex

1909 ◽  
Vol 29 ◽  
pp. 607-618
Author(s):  
D. Berry Hart
Keyword(s):  
Fallopian Tube ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Definite Form ◽  
Human Male ◽  
Prostatic Utricle ◽  
Opposite Sex ◽  
Vaginal Tract ◽  
Appendix Testis ◽  
Female Genital

(Abstract)It has long been known that the male and the female human genital tract contain not only organs characteristic of their sex proper, but also certain parts of the opposite sex in a less developed but yet perfectly definite form. Thus the female genital tract is made up of, not only its characteristic organs, the ovaries, tubes, uterus, etc., but also the epoophoron (parovarium) and its duct, the equivalent of the epididymis and ductus epididymis of the testis. In the same way, the human male has his characteristic sexual organs and also the appendix testis and prostatic utricle, the representatives of the fimbriated end of the Fallopian tube and of the lower end of the vaginal tract (hymen mainly, but varying).

scholarly journals Immunohistochemical expression of keratan sulfate: a possible diagnostic marker for carcinomas of the female genital tract

2011 ◽  
Vol 64 (12) ◽  
pp. 1058-1063 ◽  
Author(s):  
Tsutomu Miyamoto ◽  
Keiko Ishii ◽  
Ryouichi Asaka ◽  
Akihisa Suzuki ◽  
Akiko Takatsu ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Urinary Tract ◽  
Gastrointestinal Tract ◽  
Fallopian Tube ◽  
Genital Tract ◽  
Diagnostic Marker ◽  
Female Genital Tract ◽  
Keratan Sulfate ◽  
Digestive Organs ◽  
Female Genital

AimsThe authors previously reported the expression of keratan sulfate (KS), a glycosaminoglycan, in the epithelium of normal and neoplastic endometria. The aim of this study was to evaluate its potential use as a diagnostic marker, and the expression of KS was investigated in other human epithelial tissues.MethodsExpression was examined immunohistochemically using 102 samples of normal epithelia and 110 samples of carcinomas from the female genital tract (FGT; cervix, endometrium, ovary, fallopian tube), digestive organs (gastrointestinal tract, pancreas, liver), urinary tract, lung, mammary gland, thyroid and mesothelium.ResultsIn normal tissues, KS was consistently detected in the FGT and ectopic endometrium (25/26), but was not found in the digestive organs (1/42) and urinary tract (0/6), and was only partly detected in the lung (7/10), mammary gland (3/9) and thyroid (4/4). In malignant tissues, KS was consistently observed in carcinomas of the endometrium, ovary and fallopian tube (29/32), and was partly detected in carcinomas of the lung, mammary gland, thyroid, pancreas and mesothelium, but was absent in carcinomas of the gastrointestinal tract (0/17), liver (0/5) and urinary tract (0/11). Among carcinomas of the FGT, digestive organs and urinary tract, KS positivity suggested the possibility of FGT carcinomas, with 79.5% (31/39) sensitivity and 92.9% (39/42) specificity.ConclusionsKS is a potentially useful marker for the supportive diagnosis of the primary site of metastatic carcinomas or unknown primary carcinomas, especially in the abdominal cavity.

scholarly journals Primary Fallopian Tube Carcinoma (PFTC), A Rare Malignancy of Female Genital Tract

2019 ◽  
Vol 38 (1) ◽  
pp. 49-52
Author(s):  
Farhana Binte Rashid ◽  
Mohammad Abul Kalam Azad
Keyword(s):  
Fallopian Tube ◽  
Genital Tract ◽  
Frozen Section ◽  
Correct Diagnosis ◽  
Female Genital Tract ◽  
Total Abdominal Hysterectomy ◽  
Ultrasound Finding ◽  
Fallopian Tube Carcinoma ◽  
Primary Fallopian Tube Carcinoma ◽  
Female Genital

Background: Primary fallopian tube carcinoma (PFTC) is one of the rarest malignancies of female genital tract. It represents <1% of all gynecologic malignancies. Preoperative diagnosis is uncommon due to its rarity and non-specific symptoms. In most cases diagnosis is made during surgery or histological examination. Rarity of this type of carcinoma prompted us to report it as individual case. Case: A 40-yearold parous women presented with bilateral PFTC. The patient gave a history of lower abdominal and pelvic pain for 2 years on several occasions. An abdominal ultrasound finding showed an adnexal mass and her CA125 level was 30IU/ml (normal- <35IU/ml). Clinically she was suspected as a case of pelvic inflammatory disease (PID). She underwent Total Abdominal Hysterectomy with bilateral salpingoophorectomy. Intraoperative findings were consistent with PID. Final pathologic analysis showed bilateral primary fallopian tube carcinoma —well differentiated serous adenocarcinoma. Post operatively she was referred for oncological management. Conclusion: Malignancy should be considered in the differential diagnosis of PID especially in premenopausal age and intraoperative frozen section biopsy is crucial to make correct diagnosis and to allow appropriate surgical staging. J Bangladesh Coll Phys Surg 2020; 38(1): 49-52

Identification of Female Cells in Postcoital Penile Swabs Using Fluorescence In Situ Hybridization

2000 ◽  
Vol 124 (7) ◽  
pp. 1080-1082
Author(s):  
Kim A. Collins ◽  
Stephen J. Cina ◽  
Mark J. Pettenati ◽  
Matthew Fitts
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Male Participant ◽  
Male And Female ◽  
Laboratory Evidence ◽  
Penile Swabs ◽  
Female Genital

Abstract Traditionally, the finding of semen, that is, spermatozoa and acid phosphatase, in cervicovaginal specimens has been considered the laboratory evidence needed to prove recent sexual contact. Recent research with fluorescence in situ hybridization (FISH) has shown that in the absence of semen, male epithelial and inflammatory cells can be found within the female genital tract. A striking paucity of literature exists pertaining to the examination of the penis of an alleged assailant for potential evidence indicative of sexual assault. The current study uses FISH to analyzepostcoital swabs of the penis for such laboratory evidence. A male and female volunteer couple consented to participate in this study. Following coitus, the male partner presented to one of the investigators for penile swabbing. Swabs were taken at varying postcoital intervals (1–24 hours) subsequent to 10 coital episodes. The male participant was instructed not to shower following coitus, but to otherwise go about daily activities until specimen collection. To obtain each sample, 4 sterile cotton-tipped applicators were slightly moistened in sterile saline and swabbed along the length of the penile shaft and around the base of the penis. From the swabs, 3 air-dried slides were prepared, coded, and blinded. As controls, swabs were taken from the buccal surfaces of both volunteers. Multicolor FISH was performed using dual X- and Y-chromosome probes, and slides were counterstained with 4′-6-diamidino-2-phenylindole (DAPI). Cells were easily visualized under a fluorescent microscope, but only cells with 2 nonoverlapping fluorescent signals were counted. Fluorescence in situ hybridization is highly sensitive and specific, and the dual probes easily distinguished between male and female cells. Female cells were identified on smears from every penile swab over the entire 1- to 24-hour postcoital interval. The FISH technique, previously successful in identifying male cells within the female genital tract, may also be employed on penile swabs. Once the presence of female cells is confirmed by FISH, the identity of the female can be confirmed by DNA analysis. Potentially, with such current molecular analyses, both the assailant and the victim can be positively identified.

Study of multiple human papillomavirus-related lesions of the lower female genital tract by in situ hybridization

1989 ◽  
Vol 20 (2) ◽  
pp. 118-123 ◽  
Author(s):  
Silvana Pilotti ◽  
Jean Gupta ◽  
Bernardina Stefanon ◽  
Giuseppe De Palo ◽  
Keerti V. Shah ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Human Papillomavirus ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Female Genital

scholarly journals Breast metastasis from pelvic high-grade serous adenocarcinoma: a report of two cases

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Yurina Harada ◽  
Makoto Kubo ◽  
Masaya Kai ◽  
Mai Yamada ◽  
Karen Zaguirre ◽  
...  
Keyword(s):  
Genital Tract ◽  
Abdominal Cavity ◽  
Female Genital Tract ◽  
Serous Carcinoma ◽  
High Grade ◽  
Peritoneal Cancer ◽  
Cancer Tumor ◽  
Stage Ivb ◽  
The Right ◽  
Female Genital

Abstract Background Metastatic tumors to the breast reportedly account for 0.5% to 2.0% of all malignant breast diseases. Such metastatic tumors must be differentiated from primary breast cancer. Additionally, few reports have described metastases of gynecological cancers to the breast. We herein report two cases of metastasis of pelvic high-grade serous adenocarcinoma to the breast. Case presentation The first patient was a 57-year-old woman with a transverse colon obstruction. Colostomy was performed, but the cause of the obstruction was unknown. We found scattered white nodules disseminated throughout the abdominal cavity and intestinal surface. Follow-up contrast-enhanced computed tomography (CT) showed an enhanced nodule outside the right mammary gland. Core needle biopsy (CNB) of the right breast mass was conducted, and immunohistochemical staining of the mass suggested a high-grade serous carcinoma of female genital tract origin. We diagnosed the patient’s condition as breast and lymph node metastasis of a high-grade serous carcinoma of the female genital tract. After chemotherapy for stage IVB peritoneal cancer, tumor reduction surgery was performed. The second patient was a 71-year-old woman with a medical history of low anterior resection for rectal cancer at age 49, partial right thyroidectomy for follicular thyroid cancer at age 53, and left lower lung metastasis at age 57. Periodic follow-up CT showed peritoneal dissemination, cancerous peritonitis, and pericardial effusion, and the patient was considered to have a cancer of unknown primary origin. Contrast-enhanced CT showed an enhanced nodule in the left mammary gland with many enhanced nodules and peritoneal thickening in the abdominal cavity. CNB of the left breast mass was conducted, and immunohistochemical staining of the mass suggested a high-grade serous carcinoma of female genital tract origin. After chemotherapy for stage IVB peritoneal cancer, tumor reduction surgery was performed. Conclusions We experienced two rare cases of intramammary metastasis of high-grade serous carcinoma of female genital tract origin. CNB was useful for confirming the histological diagnosis of these cancers that had originated from other organs. A correct diagnosis of such breast tumors is important to ensure quick and appropriate treatment.

scholarly journals Congenital absence of a part of the fallopian tube: a case report

2016 ◽  
Vol 6 (1) ◽  
pp. 320
Author(s):  
Mukta Agarwal ◽  
Hemali H. Sinha ◽  
. Anamika
Keyword(s):  
Case Report ◽  
Fallopian Tube ◽  
Genital Tract ◽  
Rare Case ◽  
Case Reports ◽  
Female Genital Tract ◽  
Fallopian Tubes ◽  
Rare Occurrence ◽  
Rare Case Report ◽  
Female Genital

Congenital malformations of female genital tract are frequently seen in Gynaecological clinics, incidence being upto 5-6% in cases of infertility. Most of these anomalies are related to uterus and vagina, abnormalities related to ovaries and fallopian tubes are of rare occurrence and the exact incidence of these anomalies are not known, only a few incidental case reports are available in literature. Here, we present a rare case report of absent mid- tubal segment of fallopian tube in a patient of infertility.

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