Erratum: Genetic studies of H group plasmids by bacteriophage P1 transduction

1981 ◽  
Vol 27 (7) ◽  
pp. 741-742
Author(s):  
Diane E. Taylor ◽  
Jessie G. Levine ◽  
Godyne Sibay ◽  
Anthony Walter
Keyword(s):  
Genetic Studies ◽  
Bacteriophage P1 ◽  
P1 Transduction

Genetic studies of H group plasmids by bacteriophage P1 transduction

1981 ◽  
Vol 27 (2) ◽  
pp. 175-183 ◽  
Author(s):  
Diane E. Taylor ◽  
Jessie G. Levine ◽  
Godyne Sibay ◽  
Anthony Walter
Keyword(s):  
Molecular Weight ◽  
Tetracycline Resistance ◽  
Streptomycin Resistance ◽  
Mechanism Of Formation ◽  
Incompatibility Group ◽  
Genetic Studies ◽  
Bacteriophage P1 ◽  
Molecular Weights ◽  
Resistance Markers ◽  
P1 Transduction

Bacteriophage P1 transduction was used to study the incompatibility group H1 plasmid pRG1251, molecular weight 120 × 106, and the incompatibility group H2 plasmid pSD114, molecular weight 166 × 106. The order of resistance (R) determinants on pSD114 was deduced from transduction and segregation experiments to be chloramphenicol-tetracycline-kanamycin-streptomycin. Resistance to tellurium and to coliphages, which are properties also encoded by many H2 plasmids, were not transduced with the other markers. On pRG1251, the ampicillin and tetracycline resistance markers appear to be located together, as do the chloramphenicol, streptomycin, and sulfamethoxazole resistance markers. Frequently, blocks of R determinants were transposed to the P1 genome or to the Escherichia coli chromosome. P1 DNA was isolated which carried the chloramphenicol, streptomycin, and sulfamethoxazole markers from pRG1251 and had a molecular weight of 64 × 106. Other P1 prophages carried R determinants from pSD114 and had molecular weights of 86 × 106. A plasmid of molecular weight 124 × 106 was also isolated which contained incompatibility determinants from P1 (incompatibility group Y) and from the H2 group plasmid. The mechanism of formation of these unusual plasmid species is discussed.

Genetic studies on bacteriophage P1

Virology ◽  
1968 ◽  
Vol 36 (4) ◽  
pp. 564-574 ◽  
Author(s):  
June Rothman Scott
Keyword(s):  
Genetic Studies ◽  
Bacteriophage P1

Moving beyond the “LDL hypothesis”

VASA ◽  
2015 ◽  
Vol 44 (5) ◽  
pp. 333-340 ◽  
Author(s):  
Christian Werner ◽  
Ulrich Laufs
Keyword(s):  
Ldl Cholesterol ◽  
Causal Relation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Clinical Trial Data ◽  
Randomised Clinical Trial ◽  
Trial Data ◽  
Low Density Lipoprotein Cholesterol ◽  
Genetic Studies ◽  
Statin Drug

Abstract. Summary: The term “LDL hypothesis” is frequently used to describe the association of low-density lipoprotein cholesterol (LDL-cholesterol, LDL-C) and cardiovascular (CV) events. Recent data from genetic studies prove a causal relation between serum LDL-C and CV events. These data are in agreement with mechanistic molecular studies and epidemiology. New randomised clinical trial data show that LDL-C lowering with statins and a non-statin drug, ezetimibe, reduces CV events. We therefore believe that the “LDL-hypothesis” has been proven; the term appears to be outdated and should be replaced by “LDL causality”.

Neuropsychological intermediate phenotypes as tools for genetic studies in schizophrenia

2009 ◽  
Vol 42 (05) ◽  
Author(s):  
H Konnerth ◽  
I Giegling ◽  
AM Hartmann ◽  
J Genius ◽  
A Ruppert ◽  
...  
Keyword(s):  
Genetic Studies ◽  
Intermediate Phenotypes

The Use of Medical Record Linkage for Population and Genetic Studies

1969 ◽  
Vol 08 (01) ◽  
pp. 07-11 ◽  
Author(s):  
H. B. Newcombe
Keyword(s):  
Record Linkage ◽  
Large Scale ◽  
Medical Record Linkage ◽  
Canadian Province ◽  
Genetic Studies ◽  
Parental Characteristics ◽  
Family Histories ◽  
The Family ◽  
Large Populations ◽  
Machine Readable

Methods are described for deriving personal and family histories of birth, marriage, procreation, ill health and death, for large populations, from existing civil registrations of vital events and the routine records of ill health. Computers have been used to group together and »link« the separately derived records pertaining to successive events in the lives of the same individuals and families, rapidly and on a large scale. Most of the records employed are already available as machine readable punchcards and magnetic tapes, for statistical and administrative purposes, and only minor modifications have been made to the manner in which these are produced.As applied to the population of the Canadian province of British Columbia (currently about 2 million people) these methods have already yielded substantial information on the risks of disease: a) in the population, b) in relation to various parental characteristics, and c) as correlated with previous occurrences in the family histories.

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