The Inhibitory Effect of Herbal Medicine -Dai Kenchu To (DKT)- on the Colonic Motility in Rats In Vitro
2001 ◽
Vol 29
(01)
◽
pp. 111-118
◽
Keyword(s):
Dai-Kenchu-To (DKT) is a herbal medicine and is currently used as the treatment of paralytic ileus in Japan. We investigated the mechanism of beneficial effects of DKT in vitro. DKT-extract powder (DKT-EP; 30–300 μg/ml) caused a significant inhibition on carbachol (CCH; 10-6)-induced contraction in a concentration dependent manner of the rat distal colon. DKT-EP (100 μg/ml) consists of 20 μg/ml of Zanthoxylum Fruit, 30 μg/ml of Ginseng Root and 50 μg/ml of Ginger Rhizome. Although each of them had no effect on CCH-induced muscle contraction, the combination of three ingredients caused a significant inhibition on CCH-induced contraction.
2016 ◽
Vol 52
(1)
◽
pp. 113-123
2004 ◽
Vol 91
(03)
◽
pp. 473-479
◽
Inhibition of Cytochrome P450 (CYP450) Isoforms by Isoniazid: Potent Inhibition of CYP2C19 and CYP3A
2001 ◽
Vol 45
(2)
◽
pp. 382-392
◽
1990 ◽
Vol 259
(4)
◽
pp. F539-F544
◽
2007 ◽
Vol 293
(5)
◽
pp. E1296-E1302
◽
2019 ◽
Vol 14
(10)
◽
pp. 1934578X1988372
2020 ◽
Vol 105
(6)
◽
pp. 1906-1917
◽