Knowing is better than thinking: a simple approach to inter-procedural optimization

1987 ◽  
Vol 22 (3) ◽  
pp. 121-122
Author(s):  
R Schooler
Keyword(s):  
Simple Approach ◽  
Better Than

scholarly journals Prediction of residue-residue contacts in CASP12 targets from its predicted tertiary structures

2017 ◽  
Author(s):  
Piyush Agrawal ◽  
Sandeep Singh ◽  
Gandharva Nagpal ◽  
Deepti Sethi ◽  
Gajendra P.S. Raghava
Keyword(s):  
Structural Biology ◽  
Tertiary Structure ◽  
Protein Structures ◽  
Simple Approach ◽  
Structural Proteomics ◽  
List Size ◽  
Tertiary Structures ◽  
Residue Contact ◽  
Residue Contacts ◽  
Better Than

AbstractOne of the challenges in the field of structural proteomics is to predict residue-residue contacts in a protein. It is an integral part of CASP competitions due to its importance in the field of structural biology. This manuscript describes RRCPred 2.0 a method participated in CASP12 and predicted residue-residue contact in targets with high precision. In this approach, firstly 150 predicted protein structures were obtained from CASP12 Stage 2 tarball and ranked using clustering-based quality assessment software. Secondly, residue-residue contacts were assigned in top 10 protein structures based on distance between residues. Finally, residue-residue contacts were predicted in target protein based on consensus/average in top 10 predicted structures. This simple approach performs better than most of CASP12 methods in the categories of TBM and TBM/FM. It ranked 1st in following categories; i) TBM domain on list size L/5, ii) TBM/FM domain on list size L/5 and iii) TBM/FM domain on Top 10. These observations indicate that predicted tertiary structure of a protein can be used for predicting residue-residue contacts in protein with high accuracy.

scholarly journals A Simple Approach to Elaborate Test bricks for Traditional Ceramic Studies

2021 ◽  
Author(s):  
Hicham El Boudour El Idrissi ◽  
Wafaa Borja ◽  
Lahcen DAOUDI ◽  
Nathalie Fagel
Keyword(s):  
Traditional Method ◽  
Smooth Surface ◽  
Construction Material ◽  
Mechanical Tests ◽  
Simple Approach ◽  
Simple Method ◽  
High Mechanical Strength ◽  
Fired Bricks ◽  
Sharp Edges ◽  
Better Than

Fired bricks have shown tremendous potential as a construction material due to their properties. However, their use required some specifications in terms of quality, resistance, and durability. In developing countries, the lack of tools to make test specimens leads to many defects in these brick specimens responsible for low durability and weak precision during mechanical tests and shrinkage. In this study, a simple and traditional method of making test bricks is presented. This simple method allows the production of bricks with the required properties. This method is especially efficient for a firm or semi-soft pastes consistency. The handmade pastes do not stick into the walls of the mold like the case of steel molds and it gives specimens with standard shape, smooth surface, and sharp edges. The resulting fired bricks exhibit high mechanical strength comparable and even better than those of conventional methods.

scholarly journals A Simple Approach for Finding a Fair Solution to Multiobjective Programming Problems

2012 ◽  
Vol 2 ◽  
pp. 21-25 ◽  
Author(s):  
P. Pandian
Keyword(s):  
Efficient Solution ◽  
Multiobjective Programming ◽  
Simple Approach ◽  
Decision Makers ◽  
Multiple Objective ◽  
New Approach ◽  
Multi Objective Programming ◽  
Multiple Objective Decision Making ◽  
Multiobjective Programming Problems ◽  
Better Than

A new approach, namely sum of objectives (SO) method is proposed to finding a fair solution to multi-objective programming problems. The proposed method is very simple, easy to use and understand and also, common approaches. It is illustrated with the help of numerical examples. The fair solution serves more better than efficient solution for decision makers when they are handling multiple objective decision making problems.

scholarly journals Simple approach to elaborate test bricks for traditional ceramic studies

2021 ◽  
Author(s):  
Hicham El Boudour El Idrissi ◽  
Wafaa Borja ◽  
Lahcen Daoudi ◽  
Nathalie Fagel
Keyword(s):  
Traditional Method ◽  
Smooth Surface ◽  
Construction Material ◽  
Mechanical Tests ◽  
Simple Approach ◽  
Simple Method ◽  
High Mechanical Strength ◽  
Fired Bricks ◽  
Sharp Edges ◽  
Better Than

Fired bricks have shown tremendous potential as a construction material due to their properties. However, their use required some specifications in terms of quality, resistance, and durability. In developing countries, the lack of tools to make test specimens leads to many defects in these brick specimens responsible for low durability and weak precision during mechanical tests and shrinkage. In this study, a simple and traditional method of making test bricks is presented. This simple method allows the production of bricks with the required properties. This method is especially efficient for a firm or semi-soft pastes consistency. The handmade pastes do not stick into the walls of the mold like the case of steel molds and it gives specimens with standard shape, smooth surface, and sharp edges. The resulting fired bricks exhibit high mechanical strength comparable and even better than those of conventional methods.

scholarly journals On Establishing QoS for Composite Services

2016 ◽  
Author(s):  
Nguyen Van Son ◽  
Vo Dinh Hieu
Keyword(s):  
Quality Of Service ◽  
Service Composition ◽  
Simple Approach ◽  
Complex Task ◽  
Composite Service ◽  
Composite Services ◽  
Better Than

Service  composition  is  a  process  of combining existing atomic services to perform a complex task. To choose atomic services for a composite service, usually  both  functionality  and  quality  of  service  (QoS) are  considered.  The  QoS  of  the  composite  service obviously  depends  on  QoS  of  atomic  services.  In  this research,  we  propose  a  simple  approach  for  the composite  service  and  atomic  services  to  establishing suitable  QoS  values.  Experiment  shows  that  our approach  is  feasible  and  significantly  better  than  the exhaustive approach in performance aspect.

scholarly journals Comparative evaluation of full-length isoform quantification from RNA-Seq

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Dimitra Sarantopoulou ◽  
Thomas G. Brooks ◽  
Soumyashant Nayak ◽  
Antonijo Mrčela ◽  
Nicholas F. Lahens ◽  
...  
Keyword(s):  
Structural Parameters ◽  
Differential Expression Analysis ◽  
Real Data ◽  
Simple Approach ◽  
Full Length ◽  
Rna Seq ◽  
Rna Transcripts ◽  
Quantification Accuracy ◽  
Isoform Quantification ◽  
Better Than

Abstract Background Full-length isoform quantification from RNA-Seq is a key goal in transcriptomics analyses and has been an area of active development since the beginning. The fundamental difficulty stems from the fact that RNA transcripts are long, while RNA-Seq reads are short. Results Here we use simulated benchmarking data that reflects many properties of real data, including polymorphisms, intron signal and non-uniform coverage, allowing for systematic comparative analyses of isoform quantification accuracy and its impact on differential expression analysis. Genome, transcriptome and pseudo alignment-based methods are included; and a simple approach is included as a baseline control. Conclusions Salmon, kallisto, RSEM, and Cufflinks exhibit the highest accuracy on idealized data, while on more realistic data they do not perform dramatically better than the simple approach. We determine the structural parameters with the greatest impact on quantification accuracy to be length and sequence compression complexity and not so much the number of isoforms. The effect of incomplete annotation on performance is also investigated. Overall, the tested methods show sufficient divergence from the truth to suggest that full-length isoform quantification and isoform level DE should still be employed selectively.

Time and Latitude in South Africa

1972 ◽  
Vol 1 ◽  
pp. 27-38
Author(s):  
J. Hers
Keyword(s):  
South Africa ◽  
Cape Town ◽  
Astronomical Observations ◽  
Royal Observatory ◽  
The Republic ◽  
Astronomical Determination ◽  
Limited Accuracy ◽  
Better Than

In South Africa the modern outlook towards time may be said to have started in 1948. Both the two major observatories, The Royal Observatory in Cape Town and the Union Observatory (now known as the Republic Observatory) in Johannesburg had, of course, been involved in the astronomical determination of time almost from their inception, and the Johannesburg Observatory has been responsible for the official time of South Africa since 1908. However the pendulum clocks then in use could not be relied on to provide an accuracy better than about 1/10 second, which was of the same order as that of the astronomical observations. It is doubtful if much use was made of even this limited accuracy outside the two observatories, and although there may – occasionally have been a demand for more accurate time, it was certainly not voiced.

Localization of immunolabels by electron microscopy and image averaging

1983 ◽  
Vol 41 ◽  
pp. 282-283
Author(s):  
J. Frank ◽  
P.-Y. Sizaret ◽  
A. Verschoor ◽  
J. Lamy
Keyword(s):  
Electron Microscopy ◽  
Single Particle ◽  
Attachment Site ◽  
Uranyl Acetate ◽  
Limulus Polyphemus ◽  
Resolution Limit ◽  
Electron Microscopic ◽  
Image Averaging ◽  
Top View ◽  
Better Than

The accuracy with which the attachment site of immunolabels bound to macromolecules may be localized in electron microscopic images can be considerably improved by using single particle averaging. The example studied in this work showed that the accuracy may be better than the resolution limit imposed by negative staining (∽2nm).The structure used for this demonstration was a halfmolecule of Limulus polyphemus (LP) hemocyanin, consisting of 24 subunits grouped into four hexamers. The top view of this structure was previously studied by image averaging and correspondence analysis. It was found to vary according to the flip or flop position of the molecule, and to the stain imbalance between diagonally opposed hexamers (“rocking effect”). These findings have recently been incorporated into a model of the full 8 × 6 molecule.LP hemocyanin contains eight different polypeptides, and antibodies specific for one, LP II, were used. Uranyl acetate was used as stain. A total of 58 molecule images (29 unlabelled, 29 labelled with antl-LPII Fab) showing the top view were digitized in the microdensitometer with a sampling distance of 50μ corresponding to 6.25nm.

Closing the GAP—A 5Å Scanning Microscope

1969 ◽  
Vol 27 ◽  
pp. 6-7
Author(s):  
A. V. Crewe
Keyword(s):  
Normal Form ◽  
The Other ◽  
Resolving Power ◽  
Scanning Microscope ◽  
Conventional Microscope ◽  
Other Hand ◽  
Closing The Gap ◽  
Thermal Sources ◽  
Better Than ◽  
Transmission Microscope

We have become accustomed to differentiating between the scanning microscope and the conventional transmission microscope according to the resolving power which the two instruments offer. The conventional microscope is capable of a point resolution of a few angstroms and line resolutions of periodic objects of about 1Å. On the other hand, the scanning microscope, in its normal form, is not ordinarily capable of a point resolution better than 100Å. Upon examining reasons for the 100Å limitation, it becomes clear that this is based more on tradition than reason, and in particular, it is a condition imposed upon the microscope by adherence to thermal sources of electrons.

Electron Microscopic Observation of the Longitudinal Organization of Poly (p-Phenylene Terephthalamide) Fibers

1982 ◽  
Vol 40 ◽  
pp. 680-681
Author(s):  
Li Li-Sheng ◽  
L.F. Allard ◽  
W.C. Bigelow
Keyword(s):  
Electron Microscopy ◽  
Mechanical Properties ◽  
Scanning Electron Microscopy ◽  
Microscopic Observation ◽  
Electron Microscopic Observation ◽  
Electron Microscopic ◽  
Aromatic Polyamides ◽  
Radial Arrangement ◽  
Scanning Electron ◽  
Better Than

The aromatic polyamides form a class of fibers having mechanical properties which are much better than those of aliphatic polyamides. Currently, the accepted morphology of these fibers as proposed by M.G. Dobb, et al. is a radial arrangement of pleated sheets, with the plane of the pleats parallel to the axis of the fiber. We have recently obtained evidence which supports a different morphology of this type of fiber, using ultramicrotomy and ion-thinning techniques to prepare specimens for transmission and scanning electron microscopy.

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