Effects of Visceral Fat Accumulation Awareness on a Web-Based Weight-Loss Program: Japanese Study of Visceral Adiposity and Lifestyle Information—Utilization and Evaluation (J-VALUE)

A reduction of visceral fat is important for improvement of metabolic risk. This study was designed to compare the effects of a web-based program alone or together with measurement and self-awareness of accumulated visceral fat in Japanese workers. A new noninvasive device to measure visceral fat accumulation was introduced, and efficacy on weight-loss and improvement of healthy behaviors were examined. This study was conducted according to Helsinki declaration and approved by the ethical committee of Japan Hospital Organization, National Kyoto Hospital. Two-hundred and sixteen overweight and obese males with BMI of more than 23 participated from 8 healthcare offices of 3 Japanese private companies. Subjects were randomly allocated into control group, Web-based weight-loss program (Web), or Web + Visceral fat measurement group (Web + VFA). Eighty-one percent of participants completed the study. Reductions of body weight, waist circumference, and BMI were the largest in Web + VFA group, and the differences between groups were significant by ANOVA. Improvements of healthy behaviors were the largest in Web + VFA group, and the differences of healthy eating improvement scores between Web + VFA and control groups were significant. Our findings suggest that measurement and awareness of visceral fat are effective in weight reduction in overweight and obese males in the workplace.

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Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight loss therapy.

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem.78.6.8200956 ◽

1994 ◽

Vol 78 (6) ◽

pp. 1515-1520 ◽

Cited By ~ 3

Author(s):

R Leenen ◽

K van der Kooy ◽

J C Seidell ◽

P Deurenberg ◽

H P Koppeschaar

Keyword(s):

Weight Loss ◽

Sex Hormones ◽

Visceral Fat ◽

Men And Women ◽

Fat Accumulation ◽

Visceral Fat Accumulation ◽

Weight Loss Therapy

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Visceral fat accumulation in obese subjects: relation to energy expenditure and response to weight loss

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1992.263.5.e913 ◽

1992 ◽

Vol 263 (5) ◽

pp. E913-E919 ◽

Cited By ~ 6

Author(s):

R. Leenen ◽

K. van der Kooy ◽

P. Deurenberg ◽

J. C. Seidell ◽

J. A. Weststrate ◽

...

Keyword(s):

Weight Loss ◽

Energy Expenditure ◽

Visceral Fat ◽

Resting Metabolic Rate ◽

Subcutaneous Fat ◽

Premenopausal Women ◽

Energy Deficit ◽

Fat Accumulation ◽

Visceral Fat Accumulation ◽

Obese Subjects

Seventy-eight healthy obese subjects, 40 premenopausal women and 38 men aged 27-51 yr received a 4.2 MJ/day energy-deficit diet for 13 wk. Resting metabolic rate (RMR) and diet-induced thermogenesis (DIT) were measured by indirect calorimetry. Abdominal subcutaneous and visceral fat areas were calculated from magnetic resonance imaging scans before and after weight loss. Before weight loss, visceral fat accumulation was positively correlated with higher levels of RMR (P < 0.05) and DIT (P < 0.01) in women but not in men. The mean weight reduction was 12.2 +/- 3.5 (SD) kg. In men but not in women, an initially large visceral fat depot was associated with a reduced loss of weight and total fat mass (P < 0.05). Within each sex, an initial abundance of visceral fat was significantly related to a larger loss of visceral fat (P < 0.001) and in men to a smaller loss of subcutaneous fat (P < 0.05). These results suggest that there may be gender differences in the associations between visceral fat accumulation and components of energy expenditure (RMR and DIT) in obese subjects. Obese subjects with an initial abundance of visceral fat do not lose more body weight but more visceral fat than subjects with less visceral fat.

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Time-Restricted Feeding in Commercial Layer Chickens Improves Egg Quality in Old Age and Points to Lack of Adipostat Activity in Chickens

Frontiers in Physiology ◽

10.3389/fphys.2021.651738 ◽

2021 ◽

Vol 12 ◽

Author(s):

Ganesan Saibaba ◽

Mark Ruzal ◽

Dima Shinder ◽

Sara Yosefi ◽

Shelly Druyan ◽

...

Keyword(s):

Feed Intake ◽

Visceral Fat ◽

Egg Production ◽

Egg Quality ◽

Feed Consumption ◽

Control Group ◽

Restricted Feeding ◽

Fat Accumulation ◽

Visceral Fat Accumulation ◽

Ad Libitum

In mammals, time-restricted feeding (TRF) with no caloric restriction provides health benefits and extends longevity, usually with a minor (∼3%) or no reduction in total food consumption. In the current study, a TRF regimen of 6 h free access to food (08:00–14:00 h) was applied to Leghorn chickens from 25 to 86 weeks of age; control birds ate freely during the light hours (06:00–20:00 h). Unexpectedly, the TRF-treated birds consumed, on average, 11.7% less food than the controls. This was manifested by an average reduction of 9.6% in body weight, 2.6-fold in visceral fat accumulation, and 6.5% in egg weight. Hen-housed egg production was reduced by 3.6% in the TRF group compared with the control, along the first 40 weeks of the follow-up (P < 0.05), and changed into a tendency of 0.7% higher egg production thereafter. Several parameters of egg quality showed significant improvement (P < 0.05) in the TRF group compared with the controls. A comparison of diurnal patterns of feed consumption revealed a higher rate of hourly consumption in the TRF group and increased consumption before dark in the control group. In conclusion, the reduced feed intake in response to the TRF treatment and loss in visceral fat accumulation supports the lack of a strong adipostat activity in chickens and different appetite regulation mechanisms compared with mammals. Therefore, future TRF studies in chickens should be adjusted by extending the ad libitum time window. The lower feed intake by the TRF-treated chickens compared with the ad libitum-fed controls seems to reduce the efficiency of egg production. Nevertheless, the improved egg quality and persistence of egg lay at the older age suggest that similarly to mammals, the TRF treatment delayed at least some of the negative impacts associated with advanced age.

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Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight loss therapy

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.78.6.1515 ◽

1994 ◽

Vol 78 (6) ◽

pp. 1515-1520 ◽

Cited By ~ 46

Author(s):

R. Leenen

Keyword(s):

Weight Loss ◽

Sex Hormones ◽

Visceral Fat ◽

Men And Women ◽

Fat Accumulation ◽

Visceral Fat Accumulation ◽

Weight Loss Therapy

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Liraglutide may affect visceral fat accumulation in diabetic rats via changes in FTO, AMPK, and AKT expression

International Journal of Diabetes in Developing Countries ◽

10.1007/s13410-021-00974-0 ◽

2021 ◽

Author(s):

Shan Xiao ◽

Ye Yang ◽

Yuetong Liu ◽

Jun Zhu

Keyword(s):

Body Weight ◽

Visceral Fat ◽

Diabetic Rats ◽

The Body ◽

Control Group ◽

Adipose Tissues ◽

Fat Accumulation ◽

Visceral Fat Accumulation ◽

Underlying Mechanisms ◽

Visceral Adipose

Abstract Purpose The aim of this study is to explore the effects of liraglutide (LRG) on the expression of FTO, AMPK, and AKT in the visceral adipose tissues of obese and diabetic rats and the underlying mechanisms thereof. Methods Thirty SPF-grade, male SD rats were randomly divided into the healthy control, diabetic model (DM), and DM + LRG groups. The DM and DM + LRG groups were administered normal saline and LRG (0.6 mg/kg/d), respectively. After 12 weeks, the body weight of the rats was measured, and their visceral adipose tissues were collected and weighed; the levels of serum biochemical indicators and FTO, AMPK, and AKT in these tissues were then measured using qRT-PCR and western blotting. Results Compared to the control group, the body weight and visceral fat accumulation and blood glucose, TG, TC, and LDL-C levels increased significantly, while the HDL-C levels decreased significantly, in the DM group (p < 0.05). After LRG treatment, the HDL-C levels increased significantly, but the levels of the other indicators decreased significantly (p < 0.05). Compared to the control group, the visceral adipose tissue levels of FTO and AKT increased significantly, while the AMPK levels decreased significantly in the DM group (p < 0.05). After LRG treatment, the FTO and AKT levels decreased significantly, and the AMPK levels increased significantly (p < 0.05). Conclusion LRG may activate and inhibit the AMPK and AKT pathways, respectively, and decrease FTO expression, thereby alleviating abdominal obesity in type 2 diabetes.

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