scholarly journals Visual Perception during Mirror-Gazing at One’s Own Face in Patients with Depression

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Giovanni B. Caputo ◽  
Marco Bortolomasi ◽  
Roberta Ferrucci ◽  
Mario Giacopuzzi ◽  
Alberto Priori ◽  
...  
Keyword(s):  
Visual Perception ◽  
Facial Expression ◽  
Facial Recognition ◽  
Face Image ◽  
Illumination Level ◽  
Healthy Controls ◽  
Self Evaluation ◽  
Low Illumination ◽  
Mirror Gazing ◽  
The Relationship

In normal observers, gazing at one’s own face in the mirror for a few minutes, at a low illumination level, produces the apparition of strange faces. Observers see distortions of their own faces, but they often see hallucinations like monsters, archetypical faces, faces of relatives and deceased, and animals. In this research, patients with depression were compared to healthy controls with respect to strange-face apparitions. The experiment was a 7-minute mirror-gazing test (MGT) under low illumination. When the MGT ended, the experimenter assessed patients and controls with a specifically designed questionnaire and interviewed them, asking them to describe strange-face apparitions. Apparitions of strange faces in the mirror were very reduced in depression patients compared to healthy controls. Depression patients compared to healthy controls showed shorter duration of apparitions; minor number of strange faces; lower self-evaluation rating of apparition strength; lower self-evaluation rating of provoked emotion. These decreases in depression may be produced by deficits of facial expression and facial recognition of emotions, which are involved in the relationship between the patient (or the patient’s ego) and his face image (or the patient’s bodily self) that is reflected in the mirror.

Impact of weight stigma on preadolescents' and adolescents' disordered eating behaviors: Testing two mediation models

2020 ◽  
Vol 48 (10) ◽  
pp. 1-15
Author(s):  
Hao Chen ◽  
Yiduo Ye ◽  
Jichang Guo
Keyword(s):  
Disordered Eating ◽  
Eating Behaviors ◽  
Weight Bias ◽  
Weight Stigma ◽  
Disordered Eating Behaviors ◽  
Self Evaluation ◽  
Weight Bias Internalization ◽  
Core Self ◽  
The Relationship ◽  
Mediation Models

We investigated potential mechanisms that may explain the relationship between weight stigma and disordered eating behaviors, using 2 mediation models. In the first model we hypothesized that the relationship between weight stigma and disordered eating behaviors would be mediated by weight bias internalization, and jointly mediated by both weight bias internalization and core self-evaluation. In the alternative model we hypothesized that this relationship would be mediated by core self-evaluation, and jointly mediated by both core selfevaluation and weight bias internalization. Participants were 421 primary and secondary school students (aged 9–14 years) representing various weight categories, who responded to items about their weight stigma, weight bias internalization, core self-evaluation, and disordered eating behaviors. Results show that the 2 mediation models had a good fit to the data. Thus, improving core self-evaluation and reducing weight bias internalization appear to be significant for treating disordered eating behaviors in preadolescents and adolescents.

scholarly journals Influence of chronotype on daily mood fluctuations: pilot study in patients with depression

BJPsych Open ◽  
2020 ◽  
Vol 6 (2) ◽  
Author(s):  
Konstantin F. Brückmann ◽  
Jürgen Hennig ◽  
Matthias J. Müller ◽  
Stanislava Fockenberg ◽  
Anne-Marthe Schmidt ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Pilot Study ◽  
Negative Affect ◽  
Clinical Setting ◽  
Early Morning ◽  
Healthy Controls ◽  
Patient Subgroup ◽  
Depression Risk ◽  
Gender And Age ◽  
The Relationship

Summary Depression risk is associated with a late chronotype pattern often described as an ‘evening chronotype’. Fluctuations in mood over consecutive days have not yet been measured according to chronotype in in-patients with depression. A total of 30 in-patients with depression and 32 healthy controls matched for gender and age completed a chronotype questionnaire and twice-daily ratings on mood for 10 consecutive days (registered in the German Clinical Trials Register: DRKS00010215). The in-patients had Saturdays and Sundays as hospital-leave days. The relationship between chronotype and daily mood was mediated by the weekday–weekend schedule with higher levels of negative affect in the evening-chronotype patient subgroup at weekends. Results are discussed with respect to a probably advantageous standardised clinical setting with early morning routines, especially for patients with evening chronotypes.

scholarly journals Glutamate connectivity associations converge upon the salience network in schizophrenia and healthy controls

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Robert A. McCutcheon ◽  
Toby Pillinger ◽  
Maria Rogdaki ◽  
Juan Bustillo ◽  
Oliver D. Howes
Keyword(s):  
Functional Connectivity ◽  
Frontal Cortex ◽  
Network Connectivity ◽  
Resonance Spectroscopy ◽  
Salience Network ◽  
Healthy Controls ◽  
1H Mrs ◽  
Before And After ◽  
Functional Brain Networks ◽  
The Relationship

AbstractAlterations in cortical inter-areal functional connectivity, and aberrant glutamatergic signalling are implicated in the pathophysiology of schizophrenia but the relationship between the two is unclear. We used multimodal imaging to identify areas of convergence between the two systems. Two separate cohorts were examined, comprising 195 participants in total. All participants received resting state functional MRI to characterise functional brain networks and proton magnetic resonance spectroscopy (1H-MRS) to measure glutamate concentrations in the frontal cortex. Study A investigated the relationship between frontal cortex glutamate concentrations and network connectivity in individuals with schizophrenia and healthy controls. Study B also used 1H-MRS, and scanned individuals with schizophrenia and healthy controls before and after a challenge with the glutamatergic modulator riluzole, to investigate the relationship between changes in glutamate concentrations and changes in network connectivity. In both studies the network based statistic was used to probe associations between glutamate and connectivity, and glutamate associated networks were then characterised in terms of their overlap with canonical functional networks. Study A involved 76 individuals with schizophrenia and 82 controls, and identified a functional network negatively associated with glutamate concentrations that was concentrated within the salience network (p < 0.05) and did not differ significantly between patients and controls (p > 0.85). Study B involved 19 individuals with schizophrenia and 17 controls and found that increases in glutamate concentrations induced by riluzole were linked to increases in connectivity localised to the salience network (p < 0.05), and the relationship did not differ between patients and controls (p > 0.4). Frontal cortex glutamate concentrations are associated with inter-areal functional connectivity of a network that localises to the salience network. Changes in network connectivity in response to glutamate modulation show an opposite effect compared to the relationship observed at baseline, which may complicate pharmacological attempts to simultaneously correct glutamatergic and connectivity aberrations.

scholarly journals Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 974
Author(s):  
Hayfa Sharif ◽  
Caroline L. Hoad ◽  
Nichola Abrehart ◽  
Penny A. Gowland ◽  
Robin C. Spiller ◽  
...  
Keyword(s):  
Linear Regression ◽  
Physiological State ◽  
Functional Constipation ◽  
Initial Study ◽  
Healthy Controls ◽  
Volume Changes ◽  
Additional Information ◽  
Symptom Reports ◽  
Magnetic Resonance Imaging Mri ◽  
The Relationship

Background: Functional constipation in children is common. Management of this condition can be challenging and is often based on symptom reports. Increased, objective knowledge of colonic volume changes in constipation compared to health could provide additional information. However, very little data on paediatric colonic volume is available except from methods that are invasive or require unphysiological colonic preparations. Objectives: (1) To measure volumes of the undisturbed colon in children with functional constipation (FC) using magnetic resonance imaging (MRI) and provide initial normal range values for healthy controls, and (2) to investigate possible correlation of colonic volume with whole gut transit time (WGTT). Methods: Total and regional (ascending, transverse, descending, sigmoid, and rectum) colon volumes were measured from MRI images of 35 participants aged 7–18 years (16 with FC and 19 healthy controls), and corrected for body surface area. Linear regression was used to explore the relationship between total colon volume and WGTT. Results: Total colonic volume was significantly higher, with a median (interquartile range) of 309 mL (243–384 mL) for the FC group than for the healthy controls of 227 mL (180–263 mL). The largest increase between patients and controls was in the sigmoid colon–rectum region. In a linear regression model, there was a positive significant correlation between total colonic volume and WGTT (R = 0.56, p = 0.0005). Conclusions: This initial study shows increased volumes of the colon in children with FC, in a physiological state, without use of any bowel preparation. Increased knowledge of colonic morphology may improve understanding of FC in this age group and help to direct treatment.

scholarly journals Decision making under ambiguity and risk in adolescent-onset schizophrenia

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dandan Li ◽  
Fengyan Zhang ◽  
Lu Wang ◽  
Yifan Zhang ◽  
Tingting Yang ◽  
...  
Keyword(s):  
Decision Making ◽  
Executive Function ◽  
Iowa Gambling Task ◽  
Clinical Symptoms ◽  
Healthy Controls ◽  
Syndrome Scale ◽  
Significant Difference ◽  
Abnormal Pattern ◽  
Negative Syndrome ◽  
The Relationship

Abstract Objective Numerous studies have identified impaired decision making (DM) under both ambiguity and risk in adult patients with schizophrenia. However, the assessment of DM in patients with adolescent-onset schizophrenia (AOS) has been challenging as a result of the instability and heterogeneity of manifestations. The Iowa Gambling Task (IGT) and Game of Dice Task (GDT), which are frequently used to evaluate DM respectively under ambiguity and risk, are sensitive to adolescents and neuropsychiatric patients. Our research intended to examine the performance of DM in a relatively large sample of patients with AOS using the above-mentioned two tasks. We also aimed to take a closer look at the relationship between DM and symptom severity of schizophrenia. Methods We compared the performance of DM in 71 patients with AOS and 53 well-matched healthy controls using IGT for DM under ambiguity and GDT for DM under risk through net scores, total scores and feedback ration. Neuropsychological tests were conducted in all participants. Clinical symptoms were evaluated by using Positive and Negative Syndrome Scale (PANSS) in 71 patients with AOS. Pearson’s correlation revealed the relationship among total score of DM and clinical and neuropsychological data. Results Compared to healthy controls, patients with AOS failed to show learning effect and had a significant difference on the 5th block in IGT and conducted more disadvantageous choices as well as exhibited worse negative feedback rate in GDT. Apart from DM impairment under risk, diminished DM abilities under ambiguity were found related to poor executive function in AOS in the present study. Conclusions Our findings unveiled the abnormal pattern of DM in AOS, mainly reflected under the risky condition, extending the knowledge on the performance of DM under ambiguity and risk in AOS. Inefficient DM under risk may account for the lagging impulse control and the combined effects of developmental disease. In addition, our study demonstrated that the performance on IGT was related to executive function in AOS.

The Psychologist-Educator Views the Relationship of Vision to Reading and Related Learning Disabilities

1981 ◽  
Vol 14 (10) ◽  
pp. 565-567 ◽  
Author(s):  
Jules C. Abrams
Keyword(s):  
Learning Disabilities ◽  
Visual Field ◽  
Visual Perception ◽  
Learning Disability ◽  
Visual Defects ◽  
Considerable Controversy ◽  
Visual Problems ◽  
Relationship Of ◽  
The Relationship

The role of visual problems in learning disability has been a source of considerable controversy for many years. One major issue in the continuing argument is the frequent confusion of labels and concepts in the visual field. It is important to view vision as a psychophysiologic mechanism and to differentiate it from a mechanistic orientation emphasizing the eyes. Most visual problems related to learning disability represent a breakdown in the ability of the eyes to function in an harmonious fashion, that is, some interference in binocular function. While visual defects should not be confused with defects in visual perception, the identification and treatment of visual problems is an important element in the diagnosis and remediation of learning disabilities.

scholarly journals The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis

2018 ◽  
Vol 315 (1) ◽  
pp. L1-L10 ◽  
Author(s):  
Tsukasa Okamoto ◽  
Susan K. Mathai ◽  
Corinne E. Hennessy ◽  
Laura A. Hancock ◽  
Avram D. Walts ◽  
...  
Keyword(s):  
Pulmonary Fibrosis ◽  
Lung Injury ◽  
Lung Tissue ◽  
Complement System ◽  
Fold Increase ◽  
Complement C3 ◽  
Healthy Controls ◽  
C3 Gene ◽  
The Relationship ◽  
The Complement System

The common gain-of-function MUC5B promoter variant ( rs35705950 ) is the strongest risk factor for the development of idiopathic pulmonary fibrosis (IPF). While the role of complement in IPF is controversial, both MUC5B and the complement system play a role in lung host defense. The aim of this study was to evaluate the relationship between complement component 3 (C3) and MUC5B in patients with IPF and in bleomycin-induced lung injury in mice. To do this, we evaluated C3 gene expression in whole lung tissue from 300 subjects with IPF and 175 healthy controls. Expression of C3 was higher in IPF than healthy controls {1.40-fold increase [95% confidence interval (CI) 1.31–1.50]; P < 0.0001} and even greater among IPF subjects with the highest-risk IPF MUC5B promoter genotype [TT vs. GG = 1.59-fold (95% CI 1.15–2.20); P < 0.05; TT vs. GT = 1.66-fold (95% CI 1.20–2.30); P < 0.05]. Among subjects with IPF, C3 expression was significantly higher in the lung tissue without microscopic honeycombing than in the lung tissue with microscopic honeycombing [1.40-fold increase (95% CI 1.23– 1.59); P < 0.01]. In mice, while bleomycin exposure increased Muc5b protein expression, C3-deficient mice were protected from bleomycin-induced lung injury. In aggregate, our findings indicate that the MUC5B promoter variant is associated with higher C3 expression and suggest that the complement system may contribute to the pathogenesis of IPF.

The Medium and the Message

1999 ◽  
Vol 2 (2) ◽  
pp. 187-215 ◽  
Author(s):  
Wendy Sandler
Keyword(s):  
Facial Expression ◽  
Sign Language ◽  
Spoken Language ◽  
Sign Languages ◽  
Prosodic Word ◽  
Special Stress ◽  
New Perspective ◽  
New Evidence ◽  
Phonological Phrase ◽  
The Relationship

In natural communication, the medium through which language is transmitted plays an important and systematic role. Sentences are broken up rhythmically into chunks; certain elements receive special stress; and, in spoken language, intonational tunes are superimposed onto these chunks in particular ways — all resulting in an intricate system of prosody. Investigations of prosody in Israeli Sign Language demonstrate that sign languages have comparable prosodic systems to those of spoken languages, although the phonetic medium is completely different. Evidence for the prosodic word and for the phonological phrase in ISL is examined here within the context of the relationship between the medium and the message. New evidence is offered to support the claim that facial expression in sign languages corresponds to intonation in spoken languages, and the term “superarticulation” is coined to describe this system in sign languages. Interesting formaldiffer ences between the intonationaltunes of spoken language and the “superarticulatory arrays” of sign language are shown to offer a new perspective on the relation between the phonetic basis of language, its phonological organization, and its communicative content.

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