scholarly journals Association between Hyperhomocysteinemia and Thyroid Hormones in Euthyroid Diabetic Subjects

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Yun Zhang ◽  
Qiong Wang ◽  
Quanzhong Li ◽  
Ping Lu
Keyword(s):  
Blood Pressure ◽  
Fasting Glucose ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Diabetic Patients ◽  
Biomedical Data ◽  
Sectional Study ◽  
Free Triiodothyronine ◽  
Cross Sectional ◽  
Elderly Males

Objectives. The concept now emerging is that higher thyroid-stimulating hormone (TSH) and lower thyroid hormone levels within the euthyroid range may adversely affect atherosclerosis. The present study aimed to investigate the potential associations between thyroid parameters and hyperhomocysteinaemia in a cohort of euthyroid diabetic subjects.Material and Methods. Two hundred and seventy-three euthyroid diabetic subjects (167 males and 106 females) were consecutively recruited in this cross-sectional study. Clinical and biomedical data was collected.Results. TSH level was higher in females than males. Compared to normal-homocysteine group, hyperhomocysteinaemia group was more likely to be elderly, males, with longer diabetes history, and with lower diastolic blood pressure. Free thyroxine (FT4) level was lower in hyperhomocysteinaemia group than in normal-homocysteine group; however, it was not statistically significant. Adjusted for age, sex, body mass index, duration of diabetes, blood pressure, fasting glucose, total cholesterol, and triglyceride in logistic regression analyses, hyperhomocysteinaemia was significantly correlated with FT4 (P=0.021). No significant association was found with TSH or free triiodothyronine. When analyzed in subjects with TSH < 2.5 uIU/mL separately, we got similar results.Conclusions. In conclusion, we identified a relation between hyperhomocysteinemia and FT4 in a group of euthyroid diabetic patients.

scholarly journals Management and treatment patterns of diabetes patients having blood pressure complications living in Dhaka city, Bangladesh

2016 ◽  
Vol 2 (3) ◽  
pp. 458-463
Author(s):  
AHM Mahmudur Rahman ◽  
Lutful Haque Saran ◽  
Md Mamun Ur Rashid ◽  
Adnan Taher
Keyword(s):  
Blood Pressure ◽  
Cross Sectional Study ◽  
Treatment Patterns ◽  
Diabetic Patients ◽  
Survey Questionnaire ◽  
Dhaka City ◽  
Sectional Study ◽  
Cross Sectional ◽  
Almost All ◽  
Diabetes Patients

A study way carried out in Dhaka city to find out the management and treatment patterns of diabetic patients those having blood pressure complications. It was a cross sectional study of 150 patients by using self administered survey questionnaire and founded data was analyzed and described. In this study, it is found that almost all of the patients (92%) were from Dhaka and just were a few those were outsider but came as referred patients. The male and female percentages were accordingly 64.67% and 35.33% and among those diabetes patients 47.33% had hypertension and 10.66% had hypotension and most of them (74%) check their diabetes monthly. Among those patients 79.33% patients were prescribed only drugs while 17% patients were prescribed to change their routine only and 4% were prescribed both (drug and routine). Most of the diabetes patients having blood pressure complicacy were prescribed only drugs which is very significant and those are going to do further research in this aspect will be benefited by getting this information.Asian J. Med. Biol. Res. September 2016, 2(3): 458-463

Microalbuminuria in Type 2 Diabetic Patients: A Cross-Sectional Study of Frequency, Sex Distribution and Relation to Hypertension

1994 ◽  
Vol 31 (2) ◽  
pp. 160-164 ◽  
Author(s):  
Thorkild Friis ◽  
Laurids R Pedersen ◽  
Susanne Arnold-Larsen ◽  
Dorthe B Nielsen
Keyword(s):  
Blood Pressure ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Sex Distribution ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
C Peptide ◽  
Type 2 Diabetic

We studied 112 type 2 diabetic patients. Fourteen patients had frank proteinuria, and 37 of the remaining 98 had microalbuminuria which was more frequent in men than in women ( P<0·02). Hypertension was found in 47 of the patients, equally distributed between sexes. Male diabetics with microalbuminuria had higher systolic blood pressure than diabetics without microalbuminuria ( P<0·02). Body mass index was higher in both sexes with hypertension compared to patients without hypertension. In the hypertensive men plasma C-peptide values were higher compared to patients without hypertension ( P<0·01) irrespective of the presence of microalbuminuria. A positive correlation between blood pressure and C-peptide was found ( P<0·01) in the men. We suggest that gender should be taken into account in the analysis and interpretation of microalbuminuria in type 2 diabetes.

scholarly journals Evaluation of autonomic neuropathy in newly diagnosed and chronic type 2 diabetic patients: A retrospective cross-sectional study

2020 ◽  
Vol 8 (1) ◽  
pp. 49-49
Author(s):  
Mahsa Esmaeillou ◽  
Jalil Houshyar ◽  
Fariborz Akbarzadeh ◽  
Akbar Aliasgarzadeh
Keyword(s):  
Blood Pressure ◽  
Autonomic Neuropathy ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Newly Diagnosed ◽  
Sectional Study ◽  
Cross Sectional ◽  
Type 2 Dm ◽  
History Of

Abstract Introduction: Diabetic autonomic neuropathy is one of the most important complications of diabetes mellitus (DM) that ultimately occurs in most patients. The purpose of this study was to screen and diagnose latent cases of autonomic neuropathy between patients who have a history of over 10 years DM and recently diagnosed diabetic patients. Methods: This cross-sectional study was performed on 104 patients (52 type 2 DM patients diagnosed in the last 6 months; and 52 type 2 DM patients with more than 10 years history) referred to outpatient Endocrine Clinic of Imam Reza Medical Center in Tabriz University of Medical Sciences between 2015-2016. Blood pressure, resting heart rate and corrected QT interval were evaluated according to standard methods. The history of gastrointestinal and urinary tract neuropathy was extracted from patients’ history and physical exam. Results: Of the 104 patients studied, 54 were male and 50 were female. Standing heart rate (p=0.02), resting (p<0.0002) and standing (p<0.0001) systolic blood pressure, and resting diastolic blood pressure (p=0.03) were significantly higher in chronic diabetic patients compared to newly diagnosed group. Additionally, blood glucose levels (p=0.03) and body mass index (BMI) (p<0.0001) were significantly higher in patients with neuropathy. Conclusion: Overall, the results of this study showed that in patients with type 2 DM, cardiac autonomic dysfunction is more common in patients with a longer history of DM.

scholarly journals Associations between thyroid-stimulating hormone and hypertension according to thyroid cyst status in the general population: a cross-sectional study

2020 ◽  
Vol 25 (1) ◽  
Author(s):  
Yuji Shimizu ◽  
Yuko Nabeshima-Kimura ◽  
Shin-Ya Kawashiri ◽  
Yuko Noguchi ◽  
Yasuhiro Nagata ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Sectional Study ◽  
Free Triiodothyronine ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
Thyroid Cyst ◽  
Stimulating Hormone

Abstract Background The absence of thyroid cysts may indicate latent thyroid damage, as demonstrated in our previous study. However, the association between the absence of thyroid cysts and latent functional damage of the thyroid is unknown. At low thyroid hormone productivity, which may be associated with latent functional damage of the thyroid, the association between thyroid-stimulating hormone (TSH) and hypertension might be enhanced. Therefore, we evaluated the association between TSH level and hypertension stratified by thyroid cyst status. Methods We conducted a cross-sectional study of 1724 euthyroid Japanese individuals aged 40–74 years who participated in an annual health checkup in 2014. Results In the study population, 564 and 686 participants had thyroid cysts and hypertension, respectively. A significant positive association was observed between TSH and hypertension in subjects without a thyroid cyst but not in subjects with thyroid cysts. There was a significant positive association between hypertension and TSH in subjects without a thyroid cyst (odds ratio [OR] 1.27; 95% confidence intervals [CI] 1.01, 1.61) but not in subjects with thyroid cysts (OR 0.79; CI 0.57, 1.09) in the model fully adjusted for known confounding factors. The correlation between the TSH and free triiodothyronine (fee T3) levels (simple correlation coefficient [r] = − 0.13, p < 0.01) was stronger in the subjects without thyroid cysts than in those with thyroid cysts (r = − 0.03, p = 0.525). Conclusions TSH is positively associated with hypertension only in individuals without thyroid cysts. The correlation between the TSH and free T3 levels was stronger in the subjects without thyroid cysts than in those with thyroid cysts. Therefore, the absence of thyroid cysts could be related to the association between TSH level and hypertension, possibly by indicating that the subjects without thyroid cysts had limited thyroid hormone reserves. Therefore, the absence of thyroid cysts could indicate the latent functional damage of the thyroid.

scholarly journals Effect of Dyslipidaemia on Arrhythmia in Diabetic Patients

2017 ◽  
Vol 46 (1) ◽  
pp. 20-24
Author(s):  
Shabnam Jahan Hoque ◽  
Aparna Rahman ◽  
Md Babul Miah ◽  
Md Zahid Alam ◽  
SM Rezaul Irfan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Risk Factor ◽  
Cross Sectional Study ◽  
P Value ◽  
Diabetic Patients ◽  
Ecg Monitoring ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cardiovascular Morbidity And Mortality

Dyslipidaemia is an important risk factor for cardiovascular morbidity and mortality. This cross-sectional study aims to find out the effect of dyslipidaemia on arrhythmia in diabetic patients. A total of sixty (60) diabetic patients, 31 were male and 29 were female, mean age was 59.58±11.38 (range 40 to 84) years with arrhythmia were selected at the department of Cardiology at Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorder(BIRDEM) General Hospital, Dhaka over a period of six months from January to July 2014. All the patients were accomplished with 24 hours Holter ECG monitoring, among them 40 were dyslipidaemia with mean age 60.7±13.1years and 20 were without dyslipidaemia with mean age 58±10.3 years (p-value was 0.424). Mean pulse, systolic and diastolic blood pressure were 78±15 (range 55-98) beats/min, 132±20 (range 90-180) mm of Hg and 79±8 (range 60-100) mm of Hg respectively. Mean maximum and minimum heart rate were 114±22 and 57±14 beats respectively. Mean cholesterol level was 222.58±55.51 mg/dl, mean triglyceride 241.26±98.81 mg/dl, LDL 135.53±35.61 mg/dl and HDL 41.46 ±15.46 mg/dl. Mean supraventricular beats in 24 hours was 12031± 4201 with dyslipidaemia and 8522± 2099 without dyslipidaemia which was statistically significant. Mean ventricular beats in 24 hours was 13472 ± 4872 with dyslipidaemia and 8754 ± 2689 without dyslipidaemia which was also statistically significant. Arrhythmia was found more common among diabetic patients having dyslipidaemia than without dyslipidaemia.Bangladesh Med J. 2017 Jan; 46 (1): 20-24

scholarly journals HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0253841
Author(s):  
Yuji Shimizu ◽  
Shin-Ya Kawashiri ◽  
Yuko Noguchi ◽  
Yasuhiro Nagata ◽  
Takahiro Maeda ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Peroxidase ◽  
Sectional Study ◽  
Normal Range ◽  
Free Triiodothyronine ◽  
Free T4 ◽  
Cross Sectional ◽  
Normal Thyroid Function

Anti-thyroid peroxidase antibody (TPO-Ab) is revealed to be inversely associated with thyroid cysts among euthyroid population. TPO-Ab causes autoimmune thyroiditis by bolstering thyroid inflammation. Therefore, at least partly, absence of thyroid cysts could indicate latent thyroid damage. Since participants with subclinical hypothyroidism are reported to have higher HbA1c than normal healthy controls, HbA1c could be inversely associated with thyroid cysts through a mechanism reflecting latent thyroid damage. To investigate the association between HbA1c and thyroid cysts among a euthyroid population, a cross-sectional study was conducted on 1,724 Japanese individuals who were within the normal range of thyroid function [i.e., normal range of free triiodothyronine (T3) and free thyroxine (T4)] and aged 40–74 years. Among this study population, 564 were diagnosed with thyroid cysts. Independently of thyroid related hormones [thyroid stimulating hormone (TSH), free T3, and free T4] and known cardiovascular risk factors, HbA1c was found to be significantly inversely associated with the presence of thyroid cysts. This association remained significant even after this analysis was limited to participants within a normal range of TSH. The fully adjusted odds ratios (ORs) of thyroid cysts for 1 standard deviation (SD) increment of HbA1c were 0.84 (0.74, 0.95) for total participants and 0.80 (0.70, 0.92) for participants within a normal range of TSH. Among participants with normal thyroid function, HbA1c was inversely associated with the presence of thyroid cysts. The absence of thyroid cysts and higher levels of HbA1c could indicate the latent functional damage of the thyroid.

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