scholarly journals Ovarian Carcinosarcoma and Its Association with Mature Cystic Teratoma and Primary Tubal Carcinoma

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Sunida Rewsuwan ◽  
Nopporn Satabongkoch ◽  
Prapaporn Suprasert ◽  
Surapan Khunamornpong
Keyword(s):  
Fallopian Tube ◽  
Epithelial Mesenchymal Transition ◽  
Cystic Teratoma ◽  
Pelvic Mass ◽  
Mature Cystic Teratoma ◽  
High Grade ◽  
Ovarian Mass ◽  
Serous Adenocarcinoma ◽  
Mesenchymal Transition ◽  
Ovarian Carcinosarcoma

Introduction. Carcinosarcoma is an uncommon form of ovarian cancers, classified as being part of the group of mixed epithelial and mesenchymal tumors. The occurrence of carcinosarcoma in association with a mature cystic teratoma and synchronous tubal carcinoma is very rare.Case Report. A 69-year-old woman presented with a pelvic mass. An abdominal computerized tomographic scan detected a 15 cm right pelvic mass which was suggestive of malignant transformation of a dermoid cyst. Intraoperative, bilateral ovarian masses (left 10 cm and right 12 cm) with diffuse peritoneal metastatic nodules were identified. Histologically, the left ovarian mass was composed of 2 components including carcinosarcoma and mature cystic teratoma, whereas the right ovarian mass represented a mature cystic teratoma with serosal surface involvement of high-grade serous adenocarcinoma. The left fallopian tube was macroscopically unremarkable but contained a 5.0 mm focus of high-grade serous adenocarcinoma in the distal part, with adjacent serous tubal intraepithelial carcinoma.Conclusion. As the fallopian tube has recently been proposed to be an origin for a majority of pelvic or ovarian high-grade serous adenocarcinomas, tubal carcinoma may be the origin for ovarian carcinosarcomas through an epithelial-mesenchymal transition. The coexistence of ovarian carcinosarcoma and teratoma in the present case should represent a collision tumor.

scholarly journals Pancreatic Cancers with High Grade Tumor Budding Exhibit Hallmarks of Diminished Anti-Tumor Immunity

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1090
Author(s):  
Hassan Sadozai ◽  
Animesh Acharjee ◽  
Thomas Gruber ◽  
Beat Gloor ◽  
Eva Karamitopoulou
Keyword(s):  
Gene Expression ◽  
Pancreatic Cancer ◽  
Disease Progression ◽  
Immune Escape ◽  
Epithelial Mesenchymal Transition ◽  
Tumor Budding ◽  
Ductal Adenocarcinoma ◽  
Low Grade ◽  
High Grade ◽  
Mesenchymal Transition

Tumor budding is associated with epithelial-mesenchymal transition and diminished survival in a number of cancer types including pancreatic ductal adenocarcinoma (PDAC). In this study, we dissect the immune landscapes of patients with high grade versus low grade tumor budding to determine the features associated with immune escape and disease progression in pancreatic cancer. We performed immunohistochemistry-based quantification of tumor-infiltrating leukocytes and tumor bud assessment in a cohort of n = 111 PDAC patients in a tissue microarray (TMA) format. Patients were divided based on the ITBCC categories of tumor budding as Low Grade (LG: categories 1 and 2) and High Grade (HG: category 3). Tumor budding numbers and tumor budding grade demonstrated a significant association with diminished overall survival (OS). HG cases exhibit notably reduced densities of stromal (S) and intratumoral (IT) T cells. HG cases also display lower M1 macrophages (S) and increased M2 macrophages (IT). These findings were validated using gene expression data from TCGA. A published tumor budding gene signature demonstrated a significant association with diminished survival in PDAC patients in TCGA. Immune-related gene expression revealed an immunosuppressive TME in PDAC cases with high expression of the budding signature. Our findings highlight a number of immune features that permit an improved understanding of disease progression and EMT in pancreatic cancer.

scholarly journals Mature Cystic Teratoma of the Fallopian Tube in a Postmenopausal Woman: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Mustafa Erkan Sari ◽  
Ozhan Ozdemir ◽  
Pinar Kadirogullari ◽  
Funda Arpaci Ertugrul ◽  
Cemal Resat Atalay
Keyword(s):  
Postmenopausal Woman ◽  
Fallopian Tube ◽  
Frozen Section ◽  
Operative Procedure ◽  
Cystic Teratoma ◽  
Cystic Mass ◽  
Hair Follicles ◽  
Mature Cystic Teratoma ◽  
Abdominal Masses ◽  
The Right

Background. Mature cystic teratomas of the fallopian tube are extremely rare and only 54 cases have been reported in the literature. In this paper, we report a mature cystic teratoma of the fallopian tube in a postmenopausal woman and we report the review of literature of tubal cystic teratomas.Case. A 62-year-old, gravida 4 postmenopausal woman presented with pain in the right lower abdominal region for a long time. An 88 × 72 × 95 mm heterogeneous mass which contained calcifications and lipoid components was detected in the right adnexal region by transvaginal ultrasonogram (TV-USG). Serum tumour markers, namely, CA125, CA15-3, and CA19-9, were within normal range. A laparotomy revealed a 9 × 10 cm cystic mass within the fimbrial region in the right fallopian tube, and right salpingoopherectomy was performed consequently. Microscopic examination revealed squamous epithelium with sebaceous glands and hair follicles, and pseudostratified ciliated respiratory epithelium with cartilage and mucous glands. Because the frozen section resulted in a benign dermoid cyst, no further operative procedure was performed. The postoperative follow-up was uneventful and the patient was discharged on the second postoperative day.Conclusion. In cases of undetermined pelvic or abdominal masses, a teratoma of the fallopian tube should be considered.

scholarly journals Exosome-Derived LINC00960 and LINC02470 Promote the Epithelial-Mesenchymal Transition and Aggressiveness of Bladder Cancer Cells

Cells ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 1419
Author(s):  
Cheng-Shuo Huang ◽  
Jar-Yi Ho ◽  
Jung-Hwa Chiang ◽  
Cheng-Ping Yu ◽  
Dah-Shyong Yu
Keyword(s):  
Bladder Cancer ◽  
Notch Signaling ◽  
Cancer Cells ◽  
Signaling Pathways ◽  
Cancer Progression ◽  
Epithelial Mesenchymal Transition ◽  
Low Grade ◽  
High Grade ◽  
Mesenchymal Transition ◽  
Bladder Cancer Cells

Exosomes are essential for several tumor progression-related processes, including the epithelial–mesenchymal transition (EMT). Long non-coding RNAs (lncRNAs) comprise a major group of exosomal components and regulate the neoplastic development of several cancer types; however, the progressive role of exosomal lncRNAs in bladder cancer have rarely been addressed. In this study, we identified two potential aggressiveness-promoting exosomal lncRNAs, LINC00960 and LINC02470. Exosomes derived from high-grade bladder cancer cells enhanced the viability, migration, invasion and clonogenicity of recipient low-grade bladder cancer cells and activated major EMT-upstream signaling pathways, including β-catenin signaling, Notch signaling, and Smad2/3 signaling pathways. Nevertheless, LINC00960 and LINC02470 were expressed at significantly higher levels in T24 and J82 cells and their secreted exosomes than in TSGH-8301 cells. Moreover, exosomes derived from LINC00960 knockdown or LINC02470 knockdown T24 cells significantly attenuated the ability of exosomes to promote cell aggressiveness and activate EMT-related signaling pathways in recipient TSGH-8301 cells. Our findings indicate that exosome-derived LINC00960 and LINC02470 from high-grade bladder cancer cells promote the malignant behaviors of recipient low-grade bladder cancer cells and induce EMT by upregulating β-catenin signaling, Notch signaling, and Smad2/3 signaling. Both lncRNAs may serve as potential liquid biomarkers for the prognostic surveillance of bladder cancer progression.

Mature cystic teratoma of the fallopian tube

2010 ◽  
Vol 94 (7) ◽  
pp. 2708-2709 ◽  
Author(s):  
Satoe Fujiwara ◽  
Yoshiki Yamashita ◽  
Yoko Yoshida ◽  
Yoshito Terai ◽  
Kiyoji Okuda ◽  
...  
Keyword(s):  
Fallopian Tube ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma

scholarly journals Torsion of dermoid cyst in a perimenopausal woman: a case report

2018 ◽  
Vol 7 (10) ◽  
pp. 4321
Author(s):  
Kondareddy Radhika ◽  
Sonam Singh ◽  
Munikrishna M.
Keyword(s):  
Dermoid Cyst ◽  
Histopathological Examination ◽  
Lower Abdominal Pain ◽  
Cystic Teratoma ◽  
Pelvic Mass ◽  
Total Abdominal Hysterectomy ◽  
Mature Cystic Teratoma ◽  
Gravid Uterus ◽  
Abdominal Ultrasonography ◽  
Perimenopausal Woman

Mature cystic teratoma comprise 20-30% of all ovarian tumours. They are mostly seen in patients between 20 and 40 years of age and are mostly asymptomatic. Incidence of malignancy is high in perimenopausal and postmenopausal group. Here, authors report a case of torsion of dermoid cyst presenting unusually in a 45-year-old perimenopausal woman with acute abdomen. A 45-year-old perimenopausal woman presented with lower abdominal pain of 8 hours duration and 3-4 episodes of vomiting. Abdominal examination revealed a regular, firm to cystic, tender abdomino-pelvic mass corresponding to the size of 28 weeks gravid uterus by palpation. Abdominal ultrasonography revealed the presence of right ovarian cyst measuring 12.9x12.8x10.1 cm. Total abdominal hysterectomy with bilateral salpingo oopherectomy was done. Histopathological examination confirmed mature cystic teratoma. Although mature cystic teratoma is rare after 40 years age, especially in perimenopausal women and are usually malignant in that age group, it can have an unusual age presentation at 45 years with benign nature as in present case.

Mature cystic teratoma of the fallopian tube

2013 ◽  
Vol 33 (2) ◽  
pp. 120-124 ◽  
Author(s):  
G. Khatib ◽  
A. B. Guzel ◽  
U. Kucukgoz-Gulec ◽  
M. A. Vardar ◽  
A. Musaev ◽  
...  
Keyword(s):  
Fallopian Tube ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma
Sign in / Sign up

Export Citation Format

Share Document