A Conservative Weight Loss Intervention Relieves Bowel Symptoms in Morbidly Obese Subjects with Irritable Bowel Syndrome: A Prospective Cohort Study

Background. Irritable bowel syndrome (IBS) is common in subjects with morbid obesity; the effect of weight loss programs on bowel symptoms is largely unknown. Methods. This prospective cohort study explored bowel symptoms, health scores, and biomarkers in subjects with morbid obesity during a six-month-long conservative weight loss intervention. Bowel symptoms were assessed with IBS-severity scoring system (IBS-SSS) and Gastrointestinal Symptom Rating Scale-IBS. Changes in all variables and associations between the changes in bowel symptoms and the other variables were analysed. Results. Eighty-eight subjects (81% females) were included. Body mass index was reduced from 42.0 (3.6) to 38.7 (3.5) (p<0.001). IBS-SSS was reduced from 116 (104) to 81 (84) (p=0.001). In all, 19 out of 25 variables improved significantly. In subjects with and without IBS at inclusion, the improvement in IBS-SSS was 88 (95% CI 55 to 121) and 10 (95% CI −9 to 29), respectively. Improved bowel symptoms were associated with improved subjective well-being, sense of humour, and vitamin D and negatively associated with reduced body mass index. Conclusion. Body mass index and health scores improved during a conservative weight loss intervention. Subjects with IBS before the intervention had a clinically significant improvement in bowel symptoms.

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Changes in C-reactive protein, neopterin and lactoferrin differ after conservative and surgical weight loss in individuals with morbid obesity

Scientific Reports ◽

10.1038/s41598-019-54107-z ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 4

Author(s):

Martin Aasbrenn ◽

Per G. Farup ◽

Vibeke Videm

Keyword(s):

Bariatric Surgery ◽

Body Mass Index ◽

Morbid Obesity ◽

Weight Loss ◽

Body Mass ◽

Weight Loss Intervention ◽

C Reactive Protein ◽

Reactive Protein ◽

Surgical Weight Loss ◽

Weight Loss Interventions

AbstractC-reactive protein, neopterin and lactoferrin are biomarkers of atherosclerotic disease. We aimed to assess changes in these biomarkers after conservative and surgical weight loss interventions in individuals with morbid obesity, to evaluate associations between biomarker changes and changes in body mass index and HbA1c, and to study associations between changes in the biomarkers. C-reactive protein, neopterin and lactoferrin were measured before and after conservative weight loss intervention and bariatric surgery. Data were analysed with mixed models. 137 individuals (mean age 43 years) were included. Body mass index decreased from 42.1 kg/m2 to 38.9 kg/m2 after the conservative intervention, and further to 30.5 kg/m2 after bariatric surgery. All biomarkers decreased after the conservative weight loss intervention. C-reactive protein and lactoferrin continued to decrease following bariatric surgery whereas neopterin remained stable. After adjustments for change in body mass index and HbA1c, all biomarkers decreased significantly after the conservative weight loss intervention, whereas none changed after bariatric surgery. There were no consistent correlations between changes in C-reactive protein, neopterin and lactoferrin. In conclusion, biomarkers of atherosclerosis decreased after weight loss interventions but had different trajectories. Neopterin, a marker related to atherosclerotic plaque stability, decreased after conservative weight loss but not following bariatric surgery.

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Effect of Exercise and Weight Loss in People Who Have Hip Osteoarthritis and Are Overweight or Obese: A Prospective Cohort Study

Physical Therapy ◽

10.2522/ptj.20110418 ◽

2013 ◽

Vol 93 (2) ◽

pp. 137-146 ◽

Cited By ~ 24

Author(s):

Nienke Paans ◽

Inge van den Akker-Scheek ◽

Roelien G. Dilling ◽

Martine Bos ◽

Klaas van der Meer ◽

...

Keyword(s):

Body Mass Index ◽

Weight Loss ◽

Cohort Study ◽

Physical Function ◽

Body Mass ◽

Prospective Cohort Study ◽

Combination Treatment ◽

Prospective Cohort ◽

Preliminary Evidence ◽

Walking Tests

BackgroundOsteoarthritis (OA) is the most common joint disorder in the world and is recognized as a substantial source of disability. For people with OA of the knee, exercise in combination with weight loss is a proven, effective, conservative treatment option, yet evidence is lacking for people with hip OA.ObjectiveThe aim of this study was to obtain preliminary evidence of the effect of a program of exercise in combination with weight loss on physical function in people who have hip OA and are overweight or obese.DesignThis investigation was a prospective cohort study.MethodsThirty-five people who were 25 years or older, had clinical and radiological evidence of hip OA, and were overweight or obese (body mass index of >25 kg/m2) were included. They participated in an 8-month program of exercise in combination with weight loss. A body mass index of 40 kg/m2 was used as the upper limit. The primary outcome was self-reported physical function, as measured with a subscale of the Western Ontario and McMaster Universities Osteoarthritis Index. Secondary outcome measures included pain and walking tests as quantitative measures of function.ResultsParticipation in the combination program resulted in a 32.6% improvement in self-reported physical function after 8 months, a finding that could be considered clinically relevant. Significant improvements also were seen in pain and on walking tests.LimitationsThe lack of a control group was a limitation of this study.ConclusionsThis appears to be the first study investigating the effect of exercise and weight loss as a combination treatment in people with hip OA. The results provide preliminary evidence that this combination treatment is effective in people with hip OA.

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The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study

Cancers ◽

10.3390/cancers13133245 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3245

Author(s):

Emma C. Atakpa ◽

Adam R. Brentnall ◽

Susan Astley ◽

Jack Cuzick ◽

D. Gareth Evans ◽

...

Keyword(s):

Body Mass Index ◽

Weight Loss ◽

Body Mass ◽

Breast Density ◽

Small Sample ◽

Weight Loss Intervention ◽

Short Term ◽

Dense Area ◽

Short Term Change ◽

Term Change

We evaluated the association between short-term change in body mass index (BMI) and breast density during a 1 year weight-loss intervention (Manchester, UK). We included 65 premenopausal women (35–45 years, ≥7 kg adult weight gain, family history of breast cancer). BMI and breast density (semi-automated area-based, automated volume-based) were measured at baseline, 1 year, and 2 years after study entry (1 year post intervention). Cross-sectional (between-women) and short-term change (within-women) associations between BMI and breast density were measured using repeated-measures correlation coefficients and multivariable linear mixed models. BMI was positively correlated with dense volume between-women (r = 0.41, 95%CI: 0.17, 0.61), but less so within-women (r = 0.08, 95%CI: −0.16, 0.28). There was little association with dense area (between-women r = −0.12, 95%CI: −0.38, 0.16; within-women r = 0.01, 95%CI: −0.24, 0.25). BMI and breast fat were positively correlated (volume: between r = 0.77, 95%CI: 0.69, 0.84, within r = 0.58, 95%CI: 0.36, 0.75; area: between r = 0.74, 95%CI: 0.63, 0.82, within r = 0.45, 95%CI: 0.23, 0.63). Multivariable models reported similar associations. Exploratory analysis suggested associations between BMI gain from 20 years and density measures (standard deviation change per +5 kg/m2 BMI: dense area: +0.61 (95%CI: 0.12, 1.09); fat volume: −0.31 (95%CI: −0.62, 0.00)). Short-term BMI change is likely to be positively associated with breast fat, but we found little association with dense tissue, although power was limited by small sample size.

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Su1583 – Mortality Risk in Irritable Bowel Syndrome: Results from a Nationwide, Prospective Cohort Study

Gastroenterology ◽

10.1016/s0016-5085(19)38322-2 ◽

2019 ◽

Vol 156 (6) ◽

pp. S-571-S-572

Author(s):

Kyle Staller ◽

Jonas Soderling ◽

Ola Olen ◽

Hans Törnblom ◽

Braden Kuo ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Cohort Study ◽

Prospective Cohort Study ◽

Mortality Risk ◽

Prospective Cohort ◽

Irritable Bowel

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Group-Based Trajectory Analysis of Physical Activity Change in a US Weight Loss Intervention

Journal of Physical Activity and Health ◽

10.1123/jpah.2017-0484 ◽

2018 ◽

Vol 15 (11) ◽

pp. 840-846 ◽

Cited By ~ 1

Author(s):

Christopher C. Imes ◽

Yaguang Zheng ◽

Dara D. Mendez ◽

Bonny J. Rockette-Wagner ◽

Meghan K. Mattos ◽

...

Keyword(s):

Physical Activity ◽

Body Mass Index ◽

Weight Loss ◽

Body Mass ◽

Behavioral Treatment ◽

Group Membership ◽

Multinomial Logistic Regression ◽

Step Count ◽

Weight Loss Intervention ◽

Trajectory Group

Background: The obesity epidemic is a global concern. Standard behavioral treatment including increased physical activity, reduced energy intake, and behavioral change counseling is an effective lifestyle intervention for weight loss. Purpose: To identify distinct step count patterns among weight loss intervention participants, examine weight loss differences by trajectory group, and examine baseline factors associated with trajectory group membership. Methods: Both groups received group-based standard behavioral treatment while the experimental group received up to 30 additional, one-on-one self-efficacy enhancement sessions. Data were analyzed using group-based trajectory modeling, analysis of variance, chi-square tests, and multinomial logistic regression. Results: Participants (N = 120) were mostly female (81.8%) and white (73.6%) with a mean (SD) body mass index of 33.2 (3.8) kg/m2. Four step count trajectory groups were identified: active (>10,000 steps/day; 11.7%), somewhat active (7500–10,000 steps/day; 28.3%), low active (5000–7500 steps/day; 27.5%), and sedentary (<5000 steps/day; 32.5%). Percent weight loss at 12 months increased incrementally by trajectory group (5.1% [5.7%], 7.8% [6.9%], 8.0% [7.4%], and 13.63% [7.0%], respectively; P = .001). At baseline, lower body mass index and higher perceived health predicted membership in the better performing trajectory groups. Conclusions: Within a larger group of adults in a weight loss intervention, 4 distinct trajectory groups were identified and group membership was associated with differential weight loss.

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Effects of demographic factors, body mass index, alcohol drinking and smoking habits on irritable bowel syndrome: A case control study

Annals of Medical and Health Sciences Research ◽

10.4103/2141-9248.117958 ◽

2013 ◽

Vol 3 (3) ◽

pp. 391 ◽

Cited By ~ 13

Author(s):

F Fadai ◽

N Farzaneh ◽

M Ghobaklou ◽

B Moghimi-Dehkordi ◽

N Naderi

Keyword(s):

Body Mass Index ◽

Irritable Bowel Syndrome ◽

Body Mass ◽

Alcohol Drinking ◽

Case Control Study ◽

Demographic Factors ◽

Case Control ◽

Smoking Habits ◽

Irritable Bowel ◽

Control Study

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Serotonin Level and Lipid Metabolism Indices in Patients with Irritable Bowel Syndrome with Constipation Against the Background of Various Degrees of Obesity

Galician Medical Journal ◽

10.21802/gmj.2018.2.1 ◽

2018 ◽

Vol 25 (2) ◽

Author(s):

Vasyl Mishchuk ◽

Galina Grygoruk

Keyword(s):

Body Mass Index ◽

Irritable Bowel Syndrome ◽

Lipid Profile ◽

Body Mass ◽

Density Lipoprotein ◽

Functional Constipation ◽

The Body ◽

Normal Body Mass Index ◽

Serotonin Level ◽

Irritable Bowel

Recent research shows that the number of diseases associated with obesity has been increasing. In obese persons, association with functional constipation is noted in 24.0% of cases, and obesity is recorded in 60.0% of patients with functional constipation. Among the possible mechanisms for the development of such a combination are changes in serotonin level in the blood, although the existing data are ambiguous and sometimes controversial.The objective of the study is to investigate the changes in serotonin level in the blood of obese patients in combination with constipation and its relationship with the lipid profile of the blood.Materials and methods. 63 patients with obesity in combination with irritable bowel syndrome with constipation (IBSc), 24 patients with normal body mass index and 10 practically healthy people were examined. 25 patients with obesity and constipation had a body mass index of 32.8±0.24kg/m2, 28 patients – 37.8±kg/m2, and 10 patients – 42.6±0.5kg/m2. In patients with irritable bowel syndrome without obesity, the body mass index was 21.7±0.4kg/m2. The blood serotonin level and lipid profile of the blood was determined in all patients.Results. It was deermined that in case of irritable bowel syndrome with constipation, serotonin level in the blood was reduced. In obesity with IBSc, the concentration of serotonin, on the contrary, was elevated. All patients with IBSc and obesity were marked an elevated level of total cholesterol and triglycerides. A direct correlation between high levels of triglycerides and serotonin concentration in serum of such comorbid patients was detected. The increase in the degree of obesity in the presence of IBSc was accompanied by a decrease in the concentration of cholesterol of high density lipoprotein. Patients with IBSc without excessive body weight had no such deviations.Conclusions. With an increase in the degree of obesity, serotonin level in the blood increases and the lipid blood spectrum worsens.

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