scholarly journals Origin of the MRI Contrast in Natural and Hydrogel Formulation of Pineapple Juice

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Domenico Rizzo ◽  
Enrico Ravera ◽  
Marco Fragai ◽  
Giacomo Parigi ◽  
Claudio Luchinat
Keyword(s):  
Contrast Agents ◽  
Metal Ion ◽  
Sodium Acetate Solution ◽  
Acetate Solution ◽  
Oral Contrast ◽  
Manganese Ions ◽  
Relaxation Rates ◽  
Mri Contrast ◽  
Pineapple Juice ◽  
Oral Agents

Magnetic resonance imaging (MRI) often requires contrast agents to improve the visualization in some tissues and organs, including the gastrointestinal tract. In this latter case, instead of intravascular administration, oral agents can be used. Natural oral contrast agents, such as fruit juice, have the advantages of better taste, tolerability, and lower price with respect to the artificial agents. We have characterized the relaxometry profiles of pineapple juice in order to understand the origin of the increase in relaxation rates (and thus of the MRI contrast) in reference to its content of manganese ions. Furthermore, we have characterized the relaxometry profiles of pineapple juice in the presence of alginate in different amounts; the interaction of the manganese ions with alginate slows down their reorientation time to some extent, with a subsequent increase in the relaxation rates. The relaxometry profiles were also compared with those of manganese(II) solutions in 50 mmol/dm3 sodium acetate solution (same pH of pineapple juice), which revealed sizable differences, mostly in the number of water molecules coordinated to the metal ion, their lifetimes, and in the constant of the Fermi-contact interaction. Finally, the fit of the transverse relaxivity shows that the increased viscosity in the hydrogel formulations can improve significantly the negative contrast of pineapple juice at the magnetic fields relevant for clinical MRI.

scholarly journals Comparison of divalent transition metal ion paraCEST MRI contrast agents

2013 ◽  
Vol 19 (2) ◽  
pp. 191-205 ◽  
Author(s):  
Sarina J. Dorazio ◽  
Abiola O. Olatunde ◽  
Pavel B. Tsitovich ◽  
Janet R. Morrow
Keyword(s):  
Transition Metal ◽  
Contrast Agents ◽  
Metal Ion ◽  
Mri Contrast Agents ◽  
Transition Metal Ion ◽  
Mri Contrast

scholarly journals Imaging Tissue Physiology In Vivo by Use of Metal Ion-Responsive MRI Contrast Agents

2020 ◽  
Vol 13 (10) ◽  
pp. 268 ◽  
Author(s):  
Pooyan Khalighinejad ◽  
Daniel Parrott ◽  
A. Dean Sherry
Keyword(s):  
Contrast Agents ◽  
Metal Ion ◽  
Relaxation Times ◽  
Essential Element ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Mr Contrast Agents ◽  
Wide Range ◽  
Paramagnetic Metal

Paramagnetic metal ion complexes, mostly based on gadolinium (Gd3+), have been used for over 30 years as magnetic resonance imaging (MRI) contrast agents. Gd3+-based contrast agents have a strong influence on T1 relaxation times and are consequently the most commonly used agents in both the clinical and research environments. Zinc is an essential element involved with over 3000 different cellular proteins, and disturbances in tissue levels of zinc have been linked to a wide range of pathologies, including Alzheimer’s disease, prostate cancer, and diabetes mellitus. MR contrast agents that respond to the presence of Zn2+ in vivo offer the possibility of imaging changes in Zn2+ levels in real-time with the superior spatial resolution offered by MRI. Such responsive agents, often referred to as smart agents, are typically composed of a paramagnetic metal ion with a ligand encapsulating it and one or more chelating units that selectively bind with the analyte of interest. Translation of these agents into clinical radiology is the next goal. In this review, we discuss Gd3+-based MR contrast agents that respond to a change in local Zn2+ concentration.

scholarly journals THE ROLE OF BLACK TEA AND PINEAPPLE JUICE AS NEGATIVE ORAL CONTRASTS ON MAGNETIC RESONANCE CHOLANGIOPANCREATOGRAPHY (MRCP) EXAMINATION

2019 ◽  
Vol 2 (3) ◽  
pp. 121
Author(s):  
Shinta J. Hapsari ◽  
Risalatul Latifah ◽  
Muhaimin Muhaimin
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agents ◽  
Negative Contrast ◽  
Magnetic Resonance Cholangiopancreatography ◽  
Black Tea ◽  
Plain Water ◽  
Oral Contrast ◽  
Pineapple Juice ◽  
Long Time

Background: Magnetic resonance cholangiopancreatography examination is a superior examination in the detection of anatomic structures or pathological abnormalities in the human pancreatobiliary system. This examination is recommended to use negative oral contrast which aims to eliminate gastrointestinal signals that are around the pancreatobiliary system which can be a barrier to the visualization of the pancreatobiliary tract. Materials that can be used as oral contrast contrast must be able to survive for a long time in the gastrointestinal tract and contain elements of iron (Fe) and Manganese (Mn). The high Mn content of black and pineapple juice and its abundance need to be explored as contrast oral negative. Purpose: To prove the role of pineapple juice and black tea which are natural ingredients of negative oral contrast in the visualization of the pancreatobiliary system on MRCP examination. Methods: Experimental quasy studies have been carried out on 9 samples prospectively. Each sample underwent MRCP examination with three treatments, namely given black tea, pineapple juice and plain water. The image results from the three treatments were assessed by Radiology Doctors to assess the quality of their image. Results: The results showed that black tea was more effective in providing optimal image results on MRCP examination than pineapple juice and without using oral contrast contrast. The metal content of negative oral contrast can cause magnetic susceptibility which is characterized by the presence of shortening at the time of T2 relaxation. Negative contrast agents affect signal intensity usually by shortening T2 or T2 *, as an effect, areas of concern, especially areas with negative contrast agents will experience darkening. Conclusion: Black tea is effectively used as a negative oral contrat on MRCP examination.

Ultrasound Contrast Agents

1997 ◽  
Vol 13 (5_suppl) ◽  
pp. 29S-34S
Author(s):  
William B. Robinette
Keyword(s):  
Contrast Agents ◽  
Ultrasound Contrast Agents ◽  
Oral Contrast ◽  
Uniform Size ◽  
Ultrasound Contrast ◽  
Oral Agents ◽  
Organ Specific ◽  
Upper Abdomen ◽  
New Applications ◽  
Short Time

The introduction of ultrasound contrast agents will bring new applications of this diagnostic imaging technology into clinical practice. Vascular, organ-specific, and oral agents are now in clinical trials and will soon be available. The development and properties of ultrasound contrast agents, most of which are based on gas-filled microbubbles, are reviewed. The first group of agents designed to overcome the limitations of free gas bubbles were of more uniform size but were either too large to cross the pulmonary capillary bed or lasted for only a short time in the circulation. The next group was able to produce enhancement over a period of minutes, but did not enhance the parenchyma of organs. The most recently developed intravenous agents exhibit parenchymal enhancement or are tissue-specific during B-mode imaging. Oral contrast agents may be used to reduce the artifacts created by gas in the gastrointestinal tract and to more clearly image the upper abdomen. Specific agents within each of the groups are described. The use of harmonic imaging is reviewed.

Cubosomes as Carriers for MRI Contrast Agents

2017 ◽  
Vol 24 (5) ◽  
pp. 470-482 ◽  
Author(s):  
Nicolas Alcaraz ◽  
Ben J. Boyd
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast

Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T1 relaxivity and selective cytotoxicity to cancer cells

2021 ◽  
Author(s):  
Anton Popov ◽  
Maxim Artemovich Abakumov ◽  
Irina Savintseva ◽  
Artem Ermakov ◽  
Nelly Popova ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Selective Cytotoxicity ◽  
Magnetic Resonance Imaging Mri

Gd-based complexes are widely used as magnetic resonance imaging (MRI) contrast agents. The safety of previously approved contrast agents is questionable and is being re-assessed. The main causes of concern...

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