scholarly journals Prx1 Suppresses Radiation-Induced c-Jun NH2-Terminal Kinase Signaling in Lung Cancer Cells through Interaction with the Glutathione S-Transferase Pi/c-Jun NH2-Terminal Kinase Complex

2006 ◽  
Vol 66 (14) ◽  
pp. 7136-7142 ◽  
Author(s):  
Yun-Jeong Kim ◽  
Weon-Sup Lee ◽  
Clement Ip ◽  
Ho-Zoon Chae ◽  
Eun-Mi Park ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Kinase Signaling ◽  
Glutathione S Transferase ◽  
Radiation Induced

scholarly journals Resveratrol enhances ionizing radiation-induced premature senescence in lung cancer cells

2013 ◽  
Vol 43 (6) ◽  
pp. 1999-2006 ◽  
Author(s):  
HONGMEI LUO ◽  
LU WANG ◽  
BRADLEY A. SCHULTE ◽  
AIMIN YANG ◽  
SHENGSONG TANG ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Ionizing Radiation ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Premature Senescence ◽  
Radiation Induced

scholarly journals Triterpenoids from the Leaves of Centella asiatica Inhibit Ionizing Radiation-Induced Migration and Invasion of Human Lung Cancer Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Ah-Reum Han ◽  
Sanghun Lee ◽  
Sujin Han ◽  
Yeon Jin Lee ◽  
Jin-Baek Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Ionizing Radiation ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Migration And Invasion ◽  
Asiatic Acid ◽  
Human Lung Cancer Cells ◽  
Radiation Induced

Radiotherapy using ionizing radiation is a major therapeutic modality for advanced human lung cancers. However, ionizing radiation itself can induce malignant behaviors such as cancer cell migration and invasion, leading to local recurrence or distal metastasis. Therefore, safer and more effective agents that inhibit the metastatic behaviors of cancer cells in radiotherapy are needed. As a part of our ongoing search for new radiotherapy enhancers from medicinal herbs, we isolated the following triterpenoids from the ethanol extract of Centella asiatica: asiatic acid (1), madecassic acid (2), and asiaticoside (3). These compounds inhibited the ionizing radiation-induced migration and invasion of A549 human lung cancer cells at noncytotoxic concentrations. These results suggest that triterpenoids 1–3 isolated from C. asiatica are candidate natural compounds to enhance the effect of radiotherapy in patients with non-small-cell lung cancer.

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