Abstract P1-11-03: Receipt of Risk Reduction strategies among an underserved population of BRCA mutation carriers

2015 ◽  
Author(s):  
Romy Thekkekara ◽  
Christina Seelaus ◽  
Maria O"Connell ◽  
Elizabeth Marcus ◽  
Pamela S Ganschow
Keyword(s):  
Risk Reduction ◽  
Brca Mutation ◽  
Underserved Population ◽  
Mutation Carriers ◽  
Reduction Strategies ◽  
Brca Mutation Carriers ◽  
Risk Reduction Strategies

Risk reduction and survival benefit of prophylactic surgery in BRCA mutation carriers, a systematic review

2016 ◽  
Vol 212 (4) ◽  
pp. 660-669 ◽  
Author(s):  
Kandice K. Ludwig ◽  
Joan Neuner ◽  
Annabelle Butler ◽  
Jennifer L. Geurts ◽  
Amanda L. Kong
Keyword(s):  
Systematic Review ◽  
Risk Reduction ◽  
Survival Benefit ◽  
Brca Mutation ◽  
Prophylactic Surgery ◽  
Mutation Carriers ◽  
Brca Mutation Carriers

Risk-reduction surgery in BRCA mutation carriers in a Spanish population: adherence and results

2008 ◽  
Vol 10 (10) ◽  
pp. 660-664 ◽  
Author(s):  
Pedro Pérez Segura ◽  
Paula Jiménez ◽  
Helena Olivera ◽  
Raquel Andrés Conejero ◽  
Trinidad Caldés ◽  
...  
Keyword(s):  
Risk Reduction ◽  
Brca Mutation ◽  
Spanish Population ◽  
Mutation Carriers ◽  
Brca Mutation Carriers

Uptake of surgical prophylaxis in underserved, ethnic minority BRCA mutation carriers.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 45-45
Author(s):  
Heather R. Macdonald ◽  
Charite Ricker ◽  
Neisha Opper ◽  
Grace G. Wong
Keyword(s):  
Cancer Diagnosis ◽  
Brca Mutation ◽  
Medically Underserved ◽  
Prophylactic Surgery ◽  
Underserved Population ◽  
Surgical Prophylaxis ◽  
Brca Mutations ◽  
Mutation Carriers ◽  
Brca Mutation Carriers ◽  
Medically Underserved Population

45 Background: Little data exist regarding uptake of surgical prophylaxis in the underserved clinical setting. This study describes acceptance of surgical prophylaxis amongst BRCA mutation carriers in a primarily Hispanic (60%) and Asian (15%) medically underserved population. Methods: An IRB-approved retrospective chart review of deleterious or suspected deleterious BRCA mutations carriers extracted clinicopathologic data, surgical history, and family cancer history. Patients younger than the recommended age of prophylaxis, undergoing active therapy, or with metastatic cancer were excluded. Results: Forty-six carriers of known or suspected deleterious BRCA mutations expressed decisions regarding prophylactic bilateral salpingo-oophorectomy and/or mastectomy. Thirty nine women identified themselves as Hispanic, 32 from Mexico. Three women were Asian, 2 African American and 1 Middle Eastern. Forty-two patients were previously affected by cancer, with a mean age at first cancer diagnosis of 42. Four patients were unaffected. Thirty-two women with a previous cancer diagnosis accepted prophylaxis: 11 RRM plus RRSO, 10 RRSO only, 11 RRM only. Three unaffected women underwent RRSO only. None of the unaffected patients chose RRM only. Presence of an affected family member younger than 35 at time of cancer diagnosis correlated with uptake of prophylactic surgery (18 accepted vs. 1 declined; p=0.01). There was a trend towards acceptance of prophylaxis among women with earlier TNM stage that did not reach statistical significance. Conclusions: More than 50% of eligible BRCA mutation carriers in this medically underserved population underwent RRM, RRSO, or both. Young family members affected with cancer positively influenced acceptance of surgical prophylaxis. [Table: see text]

Factors influencing risk reduction surgery among BRCA mutation carriers: A qualitative analysis.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 53-53 ◽  
Author(s):  
Rachael Brandt ◽  
Cristina Polinsky ◽  
Jessica Katz ◽  
Minal Dhamankar ◽  
Rosemarie Tucci ◽  
...  
Keyword(s):  
High Risk ◽  
Qualitative Analysis ◽  
Risk Reduction ◽  
Surgical Intervention ◽  
Brca Mutation ◽  
Carrier Status ◽  
Care Providers ◽  
Factors Influencing ◽  
Mutation Carriers ◽  
Brca Mutation Carriers

53 Background: Women known to carry deleterious mutations in BRCA1 and BRCA2 have a substantially increased lifetime risk to develop breast and ovarian cancer. Current risk management options include increased surveillance, chemoprevention and risk reducing surgery. Several studies have quantitatively evaluated the reasoning of high risk women for electing surgical intervention, noting mutation carrier status as a significant, but not sole rationale for this decision. The decision for surgery has also been associated with family cancer history, anxiety, demographics, healthcare setting and prior counseling. More insights regarding factors influencing women’s choice for risk reduction are needed. Methods: To further assess factors influencing the decision to have risk reduction surgery among women in a community hospital system, 129 BRCA mutation carriers in a community-based genetic counseling program were invited to participate in a qualitative study using questionnaires. A thematic analysis was performed by two independent reviewers on open dialogue responses. Results: Of the 59 respondents, 54 completed the question specifically addressing factors regarding the decision on surgery. Of them, 32 opted for mastectomy, salpingo-oophorectomy or both and 22 opted against surgical risk reduction. Themes emerging in support of surgery included: vicarious experience attributable to a strong family history of cancer; desire for control over risk through surgical intervention; high risk perception; co-morbidities; desire for living, regarding longevity and for loved ones; fear of cancer; and skepticism related to cancer detection methods. For women opting against surgery, themes included: co-morbidities; age (too old/young); incomplete childbearing; logistics (scheduling, finances); lack of disease; and skepticism in effectiveness of surgery. Conclusions: While various factors have been studied regarding the association with or probability of women’s decisions for risk reduction surgery, a deeper comprehension of women’s reasoning can be attained through qualitative analysis. This understanding may enhance health care providers’ ability to counsel women regarding this choice.

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