Abstract IA17: The power of ONE: Immunology in the age of single cell genomics

AbstractSingle cell genomics (SCG) can provide reliable context for assembled genome fragments on the level of individual prokaryotic genomes and has rapidly emerged as an essential complement to cultivation-based and metagenomics research approaches. Targeted cell sorting approaches, which enable the selection of specific taxa by fluorescent labeling, compatible with subsequent single cell genomics offers an opportunity to access genetic information from rare biosphere members which would have otherwise stayed hidden as microbial dark matter.

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What's New Is Old: Resolving the Identity of Leptothrix ochracea Using Single Cell Genomics, Pyrosequencing and FISH

PLoS ONE ◽

10.1371/journal.pone.0017769 ◽

2011 ◽

Vol 6 (3) ◽

pp. e17769 ◽

Cited By ~ 72

Author(s):

Emily J. Fleming ◽

Amy E. Langdon ◽

Manuel Martinez-Garcia ◽

Ramunas Stepanauskas ◽

Nicole J. Poulton ◽

...

Keyword(s):

Single Cell ◽

Single Cell Genomics

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Serial single-cell genomics reveals convergent subclonal evolution of resistance as patients with early-stage breast cancer progress on endocrine plus CDK4/6 therapy

Nature Cancer ◽

10.1038/s43018-021-00215-7 ◽

2021 ◽

Author(s):

Jason I. Griffiths ◽

Jinfeng Chen ◽

Patrick A. Cosgrove ◽

Anne O’Dea ◽

Priyanka Sharma ◽

...

Keyword(s):

Breast Cancer ◽

Single Cell ◽

Early Stage ◽

Early Stage Breast Cancer ◽

Single Cell Genomics ◽

Evolution Of Resistance

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Development of a platform for single cell genomics using convex lens-induced confinement

Lab on a Chip ◽

10.1039/c5lc00492f ◽

2015 ◽

Vol 15 (14) ◽

pp. 3013-3020 ◽

Cited By ~ 17

Author(s):

Sara Mahshid ◽

Mohammed Jalal Ahamed ◽

Daniel Berard ◽

Susan Amin ◽

Robert Sladek ◽

...

Keyword(s):

Single Cell ◽

Base Pair ◽

Single Cell Analysis ◽

Lab On A Chip ◽

Cell Analysis ◽

Next Generation ◽

Single Cell Genomics ◽

Convex Lens ◽

Genomic Dnas

We present a lab-on-a-chip for the next generation of single-cell genomics, performing full-cycle single-cell analysis by demonstrating mega-base pair genomic DNAs in nanochannels extracted in situ.

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