Human Umbilical Arteries and Veins: Generation of Leukotrienes and Response to Exogenous Leukotrienes

Neonatology ◽  
1987 ◽  
Vol 52 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Priscilla J. Piper ◽  
Sara Levene
Keyword(s):  
Umbilical Arteries ◽  
Arteries And Veins

scholarly journals The Croonian lecture. On the existence of nerves in the placenta

1833 ◽  
Vol 2 ◽  
pp. 226-227
Keyword(s):  
Blood Vessels ◽  
Pregnant Uterus ◽  
Umbilical Arteries ◽  
Arteries And Veins

In this lecture the author makes known his discovery of the ex­istence of nerves, both in the fœtal and maternal portions of the pla­centa. His previous researches had led him to doubt the existence of blood-vessels without nerves, and the extreme vascularity of the placenta led him to suspect them in that organ. With the assistance of Mr. Bauer, therefore, he first examined the placenta of the Seal, the arteries and veins of which had been injected, and in which nerves were discovered, not only surrounding the umbilical arteries, but also in the uterine portion. In the pregnant uterus of the Tapir of Sumatra, in which, there being no placenta, the umbilical chord is connected with the chorion, the nerves were very conspicuous in the transparent portion of the chorion, along which the branches of the funis pass before they ar­rive at the spongy part.

Fatty acid composition of umbilical arteries and veins: Possible implications for the fetal EFA-status

Lipids ◽  
1989 ◽  
Vol 24 (6) ◽  
pp. 511-517 ◽  
Author(s):  
G. Hornstra ◽  
A. C. van Houwelingen ◽  
M. Simonis ◽  
J. M. Gerrard
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Umbilical Arteries ◽  
Arteries And Veins

Vasoactive Actions of Prostaglandins and Serotonin on Isolated Human Umbilical Arteries and Veins

1972 ◽  
Vol 50 (5) ◽  
pp. 393-399 ◽  
Author(s):  
Myung K. Park ◽  
Charles Rishor ◽  
Donald C. Dyer
Keyword(s):  
Propylene Glycol ◽  
High Concentration ◽  
Umbilical Arteries ◽  
Arteries And Veins ◽  
Prostaglandins E

Cumulative responses to prostaglandins E1 (PGE1), E2 (PGE2), F1α(PGF1α), and F2α (PGF2α) were obtained on isolated human umbilical arteries and veins. All four prostaglandins produced contractions. PGF2α was the most active prostaglandin on umbilical arteries, while PGE2 and PGF2α were equiactive and more potent than PGE1 or PGF1α on umbilical veins. 5-Hydroxytryptamine (5-HT) was at least 100 times more potent than the prostaglandins. SC-19220, a prostaglandin antagonist, in a high concentration was found to moderately antagonize the vasoactive effect of PGE2 and to slightly antagonize contractions to 5-HT. Also, propylene glycol, the solvent for SC-19220, was observed to antagonize contractions to both PGE2 and 5-HT, thereby indicating that solvent controls are necessary when evaluating compounds such as SC-19220.

The Release Of Prostacyclin (PGI2) By Pentoxyfyl- Line From Human And Animal Vascular Tissue And Its Implications For Vascular And Antiplatelet Activities

1981 ◽  
Author(s):  
H Schrör ◽  
R Matzky ◽  
T Kahlen ◽  
H Darius
Keyword(s):  
Platelet Aggregation ◽  
Vascular Tissue ◽  
Significant Inhibition ◽  
Similar Data ◽  
Isolated Artery ◽  
Umbilical Arteries ◽  
Dose Dependent Increase ◽  
Dose Dependent ◽  
Arteries And Veins

The action of pentoxyfylline (POF) on vascular tone and PGI2-release was studied in-vitro and compared to its antiplatelet activities. POF at concentrations of 10-40 μM dose-dependently increased the PGI2-formation of isolated bovine coronary arteries and veins in-vitro. Similar data were obtained with human umbilical arteries and veins. The maximum stimulation in all of the vascular tissues studied was about 2-3-fold above basal levels. Dose-dependent increase of PGI2-production was observed at concentrations of POF comparable to those which dose-dependently relaxed isolated artery strips, whereas the investigated venous tissue was relaxed by both POF and nitroglycerine but not by PGI2. In isolated guinea pig hearts the positive ionotropic action of POF (100 μM) was blocked by propranolol (10 μM), whereas the coronary relaxation remained unchanged. POF did not influence the ADP- and collagen-induced platelet aggregation in-vitro in concentrations up to 100 μM. The data suggest that POF is able to increase significantly the vascular PGI2-form- ation at concentrations above 10 μM, whereas minimum concentrations for obtaining significant inhibition of platelet aggregation in-vitro are above 100 μM. This indicates that the reported clinical efficiency of POF in protecting blood cells and improvement of regional perfusion might in part be due to stimulation of the vascular PGI2-formation.

Pressures in Umbilical Arteries and Veins of the Fetal Lamb in Utero

1958 ◽  
Vol 193 (2) ◽  
pp. 257-259 ◽  
Author(s):  
S. R. M. Reynolds ◽  
W. M. Paul
Keyword(s):  
Blood Pressure ◽  
Umbilical Artery ◽  
Fetal Death ◽  
Respiratory Activity ◽  
Umbilical Vein ◽  
Venous Pressure ◽  
Blood Pressures ◽  
Umbilical Arteries ◽  
Arteries And Veins ◽  
Respiratory Movements

During the last third of gestation in the ewe (149 days), the first branch of an umbilical artery and of an umbilical vein was catheterized. Access was obtained by going through a small opening in the uterus to the vessels, leaving the membranes intact. Blood pressures in the main artery and vein were recorded, along with carotid blood pressure and respiratory activity in the ewe. Normal venous pressures were 20–35 mm Hg; arterial pressures, 50–70 mm Hg. The pressure gradient across the placenta, 10–20 mm Hg. Arterial and venous pulsations have been observed, most often synchronous, but at times out of phase. Pressure on the uterine contents by strong respiratory movements or use of Pitocin have caused equal rises of pressure in arteries and veins. When mild and severe hypoxia occur in the ewe (10–13% O2 and 6% O2 in the inspired air), changes in blood pressure occur, but more commonly in the artery than in the vein. Venous pressure falls with terminal hypoxia, indicating a failure of cardiac output. Venous pressure has been seen to remain near normal levels even though heart rate increases or decreases and even though arterial pressure go up or down. When umbilical vein pressure fails, however, fetal death is imminent.

Relaxant effects of benzodiazepines on isolated human umbilical arteries and veins

1993 ◽  
Vol 13 (6) ◽  
pp. 373-379 ◽  
Author(s):  
A. B. Elgoyhen ◽  
P. S. Lorenzo ◽  
R. P. Rothlin ◽  
D. Spacavento ◽  
E. Adler-Graschinsky
Keyword(s):  
Umbilical Arteries ◽  
Arteries And Veins
Sign in / Sign up

Export Citation Format

Share Document