Multifokale Neoplasien der Haut: Biologie, Ätiologie und zielgerichtete Therapien von nicht-melanozytärem Hautkrebs

2018 ◽  
Vol 6 (3) ◽  
pp. 135-146
Author(s):  
Ana R. Fernandes ◽  
Ana C. Santos ◽  
Elena Sanchez-Lopez ◽  
Andjekla B. Kovačević ◽  
Marta Espina ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Photodynamische Therapie ◽  
Zielgerichtete Therapien ◽  
Aktinische Keratose ◽  
Skin Cancers ◽  
Nonmelanoma Skin Cancers

Neoplastische Hautläsionen sind multifokal auftretende, diffuse Hautinfiltrationen, die besonders in der Differentialdiagnose ulzerativer, nodulärer oder verkrustender Hautläsionen von Bedeutung sind. Nicht-melanozytäre Hautkrebsformen (nonmelanoma skin cancers, NMSC) wie das Basalzellkarzinom (basal cell carcinoma, BCC), das Plattenepithelkarzinom (squamous cell carcinoma, SCC) und die aktinische Keratose (AK) sind die häufigsten malignen Tumoren beim Menschen. BCC wachsen langsam und bilden meist keine Metastasen, wohingegen SCC ein stärker infiltrierendes, destruierendes Wachstum zeigen und Metastasen bilden. AK sind Vorstufen des kutanen SCC. Bei der klassischen NMSC-Therapie kommt die photodynamische Therapie in Verbindung mit Chemotherapeutika zur Anwendung. Das zunehmende Verständnis der Pathomechanismen, die bei der Tumorentstehung, -progression und -differenzierung eine Rolle spielen, stützt die Anwendung zielgerichteter Chemotherapien zur Verringerung der Zytotoxizität klassischer Therapien. Die vorliegende Übersichtsarbeit beschreibt den aktuellen Wissensstand über NMSC, einschließlich der Risikofaktoren, Onkogene und Karzinogenese von Hautkrebs und erörtert die herkömmliche Behandlung im Vergleich zu neuartigen therapeutischen Optionen. Übersetzung aus Skin Pharmacol Physiol 2018;31:59-73 (DOI: 10.1159/000479529)

scholarly journals Association between Blood Group and Nonmelanoma Skin Cancers (Basal Cell Carcinoma and Squamous Cell Carcinoma)

2019 ◽  
Vol 16 (13) ◽  
pp. 2267
Author(s):  
Dijana Celić ◽  
Jasna Lipozenčić ◽  
Branko Kolarić ◽  
Goran Ferenčak ◽  
Jolanda Kanižaj Rajković ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Blood Group ◽  
Squamous Cell ◽  
Basal Cell ◽  
Skin Cancers ◽  
Study Results ◽  
Nonmelanoma Skin Cancers

Background: Development of nonmelanoma skin cancers (NMSCs) has been associated with certain risk factors, but studies of the association between ABO blood group and NMSCs have been rare and inconclusive. The aim of this study was to assess the association of the previously known risk factors and blood group as a new potential risk factor in NMSCs. Methods: The study included 401 patients, 202 men, and 199 women, which included 367 diagnosed cases of basal cell carcinoma and 148 diagnosed cases of squamous cell carcinoma. The control group consisted of 438 subjects, 198 men, and 240 women. A standardized questionnaire adapted for this targeted study was used. The relation between the dependent variable (NMSCs) and independent variables was investigated by logistic regression. Results: Compared to the non AB blood group, the risk of developing NMSCs was significantly higher in the AB blood group (MOR = 2.28; 95% CI = 1.41–3.69). We established a logistic model that could best describe the probability of NMSCs development. Conclusion: Study results are expected to instigate basic research into the role of A and B antigens in normal skin epithelium, NMSCs etiopathogenesis, possible effect on metastatic potential and disease prognosis, potential tumor immunotherapy, and targeted detection and prevention in subjects at an increased risk of NMSCs development.

scholarly journals Histopathological pattern of skin cancer at tertiary referral skin health centre

2019 ◽  
Vol 9 (2) ◽  
pp. 1555-1559
Author(s):  
Ram Chandra Adhikari ◽  
Mahesh Shah ◽  
Anil Kumar Jha
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Verrucous Carcinoma ◽  
Health Centre ◽  
Female Ratio ◽  
Skin Cancers

Background: The skin is a heterogeneous organ, capable of producing various types of skin tumors. The incidence of skin cancers, including melanoma and non-melanoma has been reported to have risen in many parts of the world. In Asian and African countries, individuals with pigmented races have a much lower incidence of skin cancers despite sunny hot weather. This study is aimed to analyze age, sex and site wise of distribution of skin cancers. Materials and Methods: The study included a total of 60 patients with histopathologically proven skin cancers from January 2015 to December 2018 in the department of pathology, DI skin health and referral centre, Kathmandu, Nepal. Results: A total of 60 cases of histopathologically proven skin cancer constituted 3.69% of total skin biopsies. Patient age ranged from 15 to 88 years with mean age being 61 years. The majority of the patients were in the age group of 61-70 yrs. The male to female ratio is 1:1.3. Basal cell carcinoma was the most common skin cancer constituting 43.4%, followed by squamous cell carcinoma (28.3%). The most common site of skin cancer is head & neck (73.3%), followed by lower extremities (8.3%). Other skin cancers were Bowen’s disease, melanoma, verrucous carcinoma, keratoacanthoma, trichilemmal carcinoma, extramammary Paget’s disease, Non-Hodgkin lymphoma and metastatic tumor. Conclusions: The most common type of skin cancer is basal cell carcinoma, followed by squamous cell carcinoma and head & neck being the commonest site.

scholarly journals Climate change and its relationship with non-melanoma skin cancers

2018 ◽  
Vol 17 (12) ◽  
pp. 1913-1917 ◽  
Author(s):  
Rubén D. Piacentini ◽  
Lara Sofía Della Ceca ◽  
Adriana Ipiña
Keyword(s):  
Climate Change ◽  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Ambient Temperature ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Skin Cancers ◽  
Melanoma Skin

The increase in ambient temperature due to climate change is expected to affect the carcinogenicity of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC).

scholarly journals Tumor Suppressor Function of CYLD in Nonmelanoma Skin Cancer

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
K. C. Masoumi ◽  
Gina Shaw-Hallgren ◽  
Ramin Massoumi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Tumor Suppressor ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Hedgehog Signaling ◽  
Cancer Type ◽  
Skin Cancers

Ubiquitin and ubiquitin-related proteins posttranslationally modify substrates, and thereby alter the functions of their targets. The ubiquitination process is involved in various physiological responses, and dysregulation of components of the ubiquitin system has been linked to many diseases including skin cancer. The ubiquitin pathways activated among skin cancers are highly diverse and may reflect the various characteristics of the cancer type. Basal cell carcinoma and squamous cell carcinoma, the most common types of human skin cancer, are instances where the involvement of the deubiquitination enzyme CYLD has been recently highlighted. In basal cell carcinoma, the tumor suppressor protein CYLD is repressed at the transcriptional levels through hedgehog signaling pathway. Downregulation of CYLD in basal cell carcinoma was also shown to interfere with TrkC expression and signaling, thereby promoting cancer progression. By contrast, the level of CYLD is unchanged in squamous cell carcinoma, instead, catalytic inactivation of CYLD in the skin has been linked to the development of squamous cell carcinoma. This paper will focus on the current knowledge that links CYLD to nonmelanoma skin cancers and will explore recent insights regarding CYLD regulation of NF-κB and hedgehog signaling during the development and progression of these types of human tumors.

Analysis of Basal Cell Carcinoma and Squamous Cell Carcinoma according to Nasal Subunit Location

2021 ◽  
Author(s):  
Handan Derebaşınlıoğlu ◽  
Neşe Kurt Özkaya
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Reconstruction Method ◽  
Tumor Type ◽  
Common Location ◽  
Skin Cancers ◽  
Significant Difference

AbstractThe nose is highly vulnerable to skin cancers due to the unavoidable sun exposure. The most common localization of skin cancers on the face is nose. Although the nose appears to be a single structure, it comprises many aesthetic units with different histological and anatomical properties. Our aim was to determine the relationship between the prevalence of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), histologically and anatomically distinct nasal subunits. The study included patients who underwent excision and repair due to BCC or SCC of the nose. The lesions were classified according to their location in the following topographic subunits: tip, alar lobule, dorsum, sidewall, and medial canthal region. Patients were analyzed according to age, sex, topographic subunit, tumor type, and repair technique. There was no statistically significant difference in tumor location according to etiology (p > 0.05). The alar subunit was the most common location of BCC, while the dorsum was the most common location for SCC. There is no statistical relationship between the two most common skin cancers, BCC and SCC, and the aesthetic subunits of the nose. The only factor associated with the reconstruction method used was the subunit in which the tumor was located.

Management of Non-melanoma Skin Cancers: Basal Cell Carcinoma, Squamous Cell Carcinoma

Melanoma ◽  
2018 ◽  
pp. 591-604 ◽  
Author(s):  
Sheila Jalalat ◽  
Corin Agoris ◽  
Neil Alan Fenske ◽  
Basil Cherpelis
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Skin Cancers ◽  
Carcinoma Squamous Cell ◽  
Melanoma Skin

scholarly journals Analysis of the Histopathological Profile and Surgical Margins Resulting from Resection of Nonmelanoma Skin Cancers

2021 ◽  
Vol 5 (1) ◽  
pp. 22-26
Author(s):  
Marcus Vinícius Jardini Barbosa ◽  
◽  
Anna Rita de Cascia Carvalho Barbosa ◽  
Frederico Alonso Sabino de Freitas
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Risk Group ◽  
Surgical Margins ◽  
Cervical Region ◽  
Skin Cancers ◽  
Melanoma Skin

: Introduction: Non-melanoma skin cancer is a group of malignant neoplasms composed basically by sarcomas, basal cell carcinoma and squamous cell carcinoma. Its etiology is multifactorial with specificity for each of the two types, except for exposure to ultraviolet radiation, which is a common factor between both. When detected early, it has a high cure rate, and surgical excision with safety margins being the treatment of choice in most cases. Thus, it is important to recognize the profile of the patients, as well as the histopathological characteristics of the lesions and the medical approach used to avoid recurrences. Purpose: This study aimed to analyze the histopathological profile and surgical margins resulting from the resection of non-melanoma skin cancers in patients treated at a plastic surgery facility in Brazil. Methods: The cases of squamous cell carcinoma and the histopathological types of the basal cell carcinoma were individually analyzed for compromised margins, and later divided into a low-risk group and a high-risk group. Results: 228 lesions were resected from 141 patients. Gender distribution was 55.3% female and 44.6% male. The most affected age group was over 70 years old. The predominant histological type was basal cell carcinoma (74.6%) followed by squamous cell carcinoma (25.4%); the most affected site was the cephalic-cervical segment (71.92%). Surgical margins were compromised in 12.3% with no significant difference between the two types of carcinoma. Conclusion: There was a predominance of basal cell carcinoma (nodular type) in women over 40 years old, predominantly in the cephalic-cervical region. The number of recurrences was proportionally higher in the BCC, unrelated to the presence of positive margins. Keywords: Skin Neoplasms, Basal Cell Carcinoma, Squamous Cell Carcinoma, Recurrence, Margins of Excision.

scholarly journals Clinicopathological profile, diagnosis and treatment of skin cancers at a tertiary care center: a retrospective study

2017 ◽  
Vol 4 (8) ◽  
pp. 2549
Author(s):  
Abhishek Jina ◽  
Vineet Singh ◽  
Sunil Saini ◽  
Neena Chotan ◽  
Manu Rajan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retrospective Study ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Lower Socioeconomic Status ◽  
Lower Socioeconomic ◽  
Skin Cancers ◽  
Clinicopathological Profile

Background: Majority of skin cancers are basal cell carcinoma, Squamous cell carcinoma and Malignant melanoma which account for more than 95% of total skin malignancies. There is an increase in incidence in India over some 10 years of period. This study was done for analysing clinicopathological profile of skin malignancies and association of human papilloma virus (HPV) in skin malignancies in Himalayan Institute of Medical Sciences (HIMS, Uttarakhand, India.Methods: It was a retrospective study done on 101 patients having malignant skin lesions attending the Department of Surgery at HIMS from October 2005 to October 2008 and given their consent.Results: Out of 101 patients, 68 had squamous cell carcinoma, 21 had basal cell carcinoma and 10 had malignant melanoma, prevalence is high in men of lower socioeconomic status (M:F) 1.9:1. The mean age was 54.50 years. Most of the patients were laborers, farmers and factory workers. Ulcers and ulceroproliferative growth were common mode of presentation. Most commonly associated risk factor was exposure to sunlight, the commonest location of skin cancer was face and scalp. Wide local excision was the commonest done procedure with closure of primary defect by SSG, fasciocutaneous or cutaneous flaps. No HPV association was seen.Conclusions: Skin cancers are quite common and their incidence has increased in last few decades, in this study we found that skin cancer were more common in males of lower socioeconomic status, probable cause was increased sun exposure and chemical exposure, in respect to females. Cancer could manifest in many forms but ulcers quite common, Squamous cell carcinoma outnumbered basal cell carcinoma, Wide local excision with skin grafts was main stay of treatment.

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