scholarly journals Diagnosis of MALT Lymphoma from Surveillance Endoscopy of a Patient with a CDH1 Gene Germline Mutation

2021 ◽  
pp. 1-5
Author(s):  
Cláudia Pinto ◽  
Ana Luísa Cunha ◽  
Ângelo Rodrigues ◽  
Renata Dias ◽  
Catarina Brandão ◽  
...  
Keyword(s):  
Malt Lymphoma ◽  
B Cell Lymphoma ◽  
Signet Ring Cell ◽  
Cdh1 Gene ◽  
Surgical Specimen ◽  
Prophylactic Gastrectomy ◽  
Increased Risk ◽  
Signet Ring ◽  
Ring Cell ◽  
Surveillance Endoscopy

Carriers of the mutated CDH1 gene have an increased risk of developing early-onset signet-ring cell (diffuse) gastric cancer. We present a case of a young patient with a confirmed mutation of the CDH1 gene, who was diagnosed with a gastric marginal zone B-cell lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT lymphoma) from surveillance endoscopy. He underwent Helicobacter pylori eradication treatment and was subsequently submitted to a total prophylactic gastrectomy. The surgical specimen only revealed foci of signet-ring cell carcinoma (SRCC) in situ without lymphoma signs. We highlight here the occurrence of other pathology in high-risk patients as well as its possible influence on the decision to perform gastrectomy.

Gastric Collision Tumor of MALT Lymphoma and Signet Ring Cell Adenocarcinoma: a Rare Preoperative Diagnosis

2021 ◽  
Author(s):  
Haythem Yacoub ◽  
Nour Ben Safta ◽  
Zein El Imene Abdelaali ◽  
Sarra Ben Rejeb ◽  
Syrine Bellakhal ◽  
...  
Keyword(s):  
Malt Lymphoma ◽  
Preoperative Diagnosis ◽  
Collision Tumor ◽  
Signet Ring Cell ◽  
Signet Ring Cell Adenocarcinoma ◽  
Signet Ring ◽  
Ring Cell

A STUDY OF HISTOPATHOLOGICAL DISTRIBUTION IN COLORECTAL CANCER

2021 ◽  
pp. 24-25
Author(s):  
Shipra Singh ◽  
Kailash Chand Jat ◽  
Ajit Singh ◽  
Kunal Purohit
Keyword(s):  
Colorectal Cancer ◽  
Surgical Techniques ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Lymph Node Status ◽  
Sex Distribution ◽  
Surgical Specimen ◽  
Signet Ring ◽  
Ring Cell ◽  
Causes Of Deaths

Despite of advances in surgical techniques and adjuvant chemotherapeutic regimens, colorectal cancer remains one of the major leading causes of deaths worldwide. Histopathology is an important factor in the treatment and prognosis of cancer. The purpose of this study was to describe the different histopathological pattern in colorectal cancer. 81 cases of colorectal carcinoma received in pathology department over a period of four years were included in the study. The surgical specimen and colonoscopic biopsies' gross features were noted and samples were stained with Haematoxylin and Eosin. Detailed microscopic examination of tumor with lymph node status was done followed by histological typing. Grading of the tumor, age and sex distribution of cases were also noted. The commonest histopathological nding was adenocarcinoma 75.32% followed by mucinous adenocarcinoma 9.88% and signet ring cell carcinoma 8.64%. Among 61 cases of adenocarcinoma most commonly moderately differentiated adenocarcinoma 60.66% was noted.

Primary signet ring cell histology does not portend worse survival for early stage lung cancer following lobectomy

2021 ◽  
pp. 021849232110459
Author(s):  
Terrance Peng ◽  
Anita Yau ◽  
Li Ding ◽  
Elizabeth A. David ◽  
Sean C. Wightman ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Early Stage ◽  
Signet Ring Cell ◽  
Rank Test ◽  
Poor Prognostic Factor ◽  
Risk Of Death ◽  
Increased Risk ◽  
Signet Ring ◽  
Ring Cell ◽  
The Impact

Introduction Signet ring cell (SRC) histology is considered a poor prognostic factor in various cancers. However, primary SRC lung adenocarcinoma is rare and poorly understood. Methods The National Cancer Database was queried to identify treatment-naïve patients who received lobectomy for primary SRC or non-SRC pT1-2N0 lung adenocarcinoma <4 cm within four months of diagnosis. SRC lung adenocarcinoma was defined by ICD-O-3 code 8490, while non-SRC lung adenocarcinoma was defined by ICD-O-3 codes 8140, 8141, 8143, 8147, 8255, 8260, 8310, 8481, 8560, and 8570–8574. The Kaplan-Meier curve and log-rank test was used to compare five-year OS between SRC versus non-SRC lung adenocarcinoma cohorts. The impact of SRC histology on risk of death was assessed using the Cox proportional hazards regression model. Results 48,399 patients were included in this study: 62 with primary SRC lung adenocarcinoma and 48,337 with non-SRC lung adenocarcinoma. The mean age of the overall cohort was 67.0 ± 9.6 years. Five-year OS following lobectomy did not differ significantly between SRC lung adenocarcinoma and non-SRC lung adenocarcinoma cohorts (SRC 73.9% vs. non-SRC 69.3%, p = 0.64). SRC histology did not significantly impact risk of death within five years after lobectomy (HR 0.89, p = 0.66). Conclusions Following lobectomy for pT1-2N0 tumors <4 cm, patients with primary SRC lung adenocarcinoma do not experience worse five-year OS or increased risk of death within five years relative to those with non-SRC lung adenocarcinoma. Additional study, including exploration of emerging molecular profiling data, may serve to better define optimal treatment for this histopathologic group of lung adenocarcinomas.

P.01.28 A NEW MUTATION OF THE CDH1 GENE IN A PATIENT WITH AN AGGRESSIVE SIGNET-RING CELL CARCINOMA OF THE STOMACH

2018 ◽  
Vol 50 (2) ◽  
pp. e130-e131
Author(s):  
V. De Re ◽  
L. Caggiari ◽  
G. Miolo ◽  
V. Canzonieri ◽  
M. Fornasarig ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Cdh1 Gene ◽  
New Mutation ◽  
Carcinoma Of The Stomach ◽  
Signet Ring ◽  
Ring Cell

593 CONFOCAL LASER ENDOMICROSCOPY FOR DETECTION OF EARLY GASTRIC SIGNET RING CELL CARCINOMA IN PATIENTS WITH CDH1 GENE MUTATIONS

2020 ◽  
Vol 158 (6) ◽  
pp. S-127
Author(s):  
Samuel A. Schueler ◽  
Lauren A. Gamble ◽  
Bryan F. Curtin ◽  
Samantha M. Ruff ◽  
Maureen Connolly ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Gene Mutations ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Cdh1 Gene ◽  
Signet Ring ◽  
Ring Cell

Extreme Signet Ring Cell Change in a Large B-Cell Lymphoma of Follicular Origin

2013 ◽  
Vol 21 (4) ◽  
pp. 399-403 ◽  
Author(s):  
Agata Monika Bogusz ◽  
Bethany Tierno ◽  
Daniel Brown ◽  
German Pihan
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Signet Ring Cell ◽  
Large B Cell Lymphoma ◽  
Signet Ring ◽  
Ring Cell ◽  
Large B Cell

scholarly journals The Effect of Treatment Facility, Race, and Chemoradiation on Survival for Signet Ring Cell Carcinoma of the Esophagus: An Analysis of the National Cancer Database

2021 ◽  
pp. 1-6
Author(s):  
Jonathan Gootee ◽  
Jonathan Gootee ◽  
Claire Willman ◽  
Sarah Aurit ◽  
Peter Silberstein
Keyword(s):  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
National Cancer Database ◽  
Treatment Facility ◽  
Adjuvant Chemoradiation ◽  
Carcinoma Of The Esophagus ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Signet Ring ◽  
Ring Cell

Background: Signet ring cell carcinoma of the esophagus (SRCCE) is an aggressive tumor that represents approximately 3.5-5.0% of all esophageal cancers. Prior studies have shown a strong correlation between treating facility and survival for different cancers, but this has not been studied in SRCCE. The goal of this study is to assess differences in survival based on the type of treatment facility. Methods: There were 2,021 patients with SRCCE identified using the histology 8490 and topography codes C15.0-C15.9 in the National Cancer Database (NCDB). Descriptive analysis, Kaplan-Meier curves, and a multivariable Cox hazard regression analysis were all utilized to determine the significance of treatment facility type and other variables. Results: The cohort mostly received treatment at academic centers (47.7%). As age increased, mortality also increased (HR=1.01; 95% CI:1.01-1.02, p<0.001). Africans Americans (HR=1.44; 95% CI:1.02-2.02, p=0.036) had an increased risk of mortality when compared to Non-Hispanic Caucasians. Patients at academic facilities demonstrated a decreased risk of mortality when compared to community programmes (HR=0.73; 95% CI:0.64-0.84, p<0.001) and integrated cancer programmes (HR=0.69; 95% CI:0.58-0.83, p=0.008). Neoadjuvant chemoradiation resulted decreased mortality when compared to adjuvant chemoradiation (HR=1.41; 95% CI:1.21-1.63, p<0.001) and no chemoradiation (HR=1.84; 95% CI:1.58- 2.14, p<0.001). Conclusion: For patients diagnosed with SRCCE, receiving treatment at academic centers resulted in better survival probabilities compared to nonacademic facilities. Older patients, African Americans, increasing tumor stage, no and adjuvant chemoradiation, and comorbidities with Charlson-Deyo scores of 1 and 2+ were all associated with an increased risk of mortality from SRCCE.

CDH1 gene mutation in early-onset, colorectal signet-ring cell carcinoma

2020 ◽  
Vol 216 (5) ◽  
pp. 152912
Author(s):  
Alan Aitchison ◽  
Christopher Hakkaart ◽  
Martin Whitehead ◽  
Sadaf Khan ◽  
Sabeehuddin Siddique ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Gene Mutation ◽  
Early Onset ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Cdh1 Gene ◽  
Signet Ring ◽  
Ring Cell
Sign in / Sign up

Export Citation Format

Share Document