The aim of this in vitro study is to compare the load-to-fracture performance of polymethyl methacrylates (PMMA) provisional restorations manufactured with a traditional laboratory technique in comparison to a computer-assisted design and computer-assisted manufacturing (CAD-CAM) technique. Five interim three-unit fixed dental prostheses were fabricated with the conventional indirect technique, on a standard typodont. The same model was scanned with an intraoral scanner and the digital design of identical fixed dental prostheses was made. Then other five interim three-unit fixed dental prostheses were milled from PMMA CAD/CAM blocks with an in office milling machine. All specimens were tested for flexural strength in a universal testing machine, and the maximum load to fracture was measured. For the conventional provisional restorations, the load to fracture was 121.16 � 24.6, in comparison to CAD/CAM interim restorations, for which the load to fracture was 728.88 � 228.7. Within the limitations of this study, one can conclude that CAD/CAM provisional restorations present a higher fracture load than the conventional manufactured interim restorations.