Abstract P085: Effects of Psychological Factors on the Risk of Cardiovascular Diseases in Adolescents

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Zhen Zhang ◽  
Ren Rong Gong ◽  
Yong Yan Song ◽  
Yuan Hao Li ◽  
Minshan Hu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Psychological Factors ◽  
Longitudinal Design ◽  
Systolic Pressure ◽  
Depression Symptoms ◽  
Post Traumatic Stress ◽  
Follow Up Study ◽  
Increased Risk

The association of psychological factors with the risk of cardiovascular diseases (CVD) has been reported before. However, few studies have evaluated whether psychological factors are associated with increased risk of CVD in adolescents with longitudinal design. Our hypothesis is that post-traumatic stress disorder (PTSD) and depression may increase the risk of CVD by changing its risk factors in adolescents. A total of 746 students at a high school 10 km away from the epicenter of Wenchuan earthquake were enrolled 6 months after the earthquake, and was followed up at 18 months. A total of 737 (98.8%) students completed the study 6 months after the earthquake. In the 18-month follow-up, 478 (64.1%) students completed the study. PTSD was assessed using PTSD Checklist-Civilian Version. Beck Depression Inventory (BDI) was used to assess depression. Fasting blood samples were collected. Serum variables of lipid and glucose metabolism were analyzed. The prevalences of PTSD symptoms were 10.6% and 1.9% at 6- and 18-month follow-up respectively. At 6- and 18-month follow-up, 40.7% and 30.3% of the students were found to have depression. The subjects with PTSD had significantly higher BMI ( p <0.05), WHR ( p <0.05) and triglyceride (TG) ( p <0.05) than subjects with no PTSD 6 months after the earthquake. The boy subjects with PTSD had significantly higher BMI ( p <0.05) than boy subjects with no PTSD. The girl subjects with PTSD had significantly higher BMI ( p <0.05) and WHR ( p <0.05) than girl subjects with no PTSD. In the 18-month follow-up study, the boy subjects with PTSD had significantly lower WHR ( p <0.05) than boy subjects with no PTSD. Six months after the earthquake, subjects with depression had significantly higher BMI ( p <0.05) and WHR ( p <0.05) than subjects with no depression. The boy subjects with depression had significantly higher WHR ( p <0.05) than boy subjects with no depression. The girl subjects with depression had significantly lower total cholesterol (TC) ( p <0.05) than girl subjects with no depression. In the 18-month follow-up study, subjects with depression had significantly lower HDL-cholesterol (HDL-C) ( p <0.05) than subjects with no depression. The boy subjects with depression had significantly higher systolic pressure ( p <0.05), higher LDL-cholesterol (LDL-C) ( p <0.05) but lower HDL-C ( p <0.05) than boy subjects with no depression. The girl subjects with depression had significantly lower systolic pressure ( p <0.05) and HDL-C ( p <0.05) than girl subjects with no depression. These findings provide preliminary evidence linking of PTSD and depression symptoms with risk factors for CVD in adolescents.

scholarly journals Incidence of cardiovascular diseases and associated risk factors among subjects with type 2 diabetes – An 11-year follow up study

2014 ◽  
Vol 66 (1) ◽  
pp. 5-10 ◽  
Author(s):  
K. Umamahesh ◽  
A. Vigneswari ◽  
G. Surya Thejaswi ◽  
K. Satyavani ◽  
Vijay Viswanathan
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cardiovascular Diseases ◽  
Follow Up Study ◽  
Associated Risk Factors

Psychological factors and incident heart disease

ESC CardioMed ◽  
2018 ◽  
pp. 3041-3041
Author(s):  
Susanne Pedersen
Keyword(s):  
Risk Factors ◽  
Traumatic Stress ◽  
Psychological Factors ◽  
Hazard Ratio ◽  
Post Traumatic Stress ◽  
Vital Exhaustion ◽  
Increased Risk ◽  
Post Traumatic ◽  
Traditional Risk Factors ◽  
Artery Disease

Psychological factors, such as depression, have long been known to be associated with an increase in the risk of onset of coronary artery disease (CAD) in initially healthy individuals. Recent reviews and meta-analyses also confirm a potential link between anxiety and incident CAD, with up to a 52% increased risk, independent of depression and traditional risk factors. A recent study in women found that exposure to trauma and post-traumatic stress accounted for 47% of the association with incident CAD, while health behaviours and traditional risk factors accounted for 14% in comparison. This is concurrent with an earlier meta-analytic review of 362,950 individuals, which found a 55% increased risk of onset of CAD associated with post-traumatic stress disorder, which was reduced to a 27% risk when also adjusting for depression and other covariates. Other factors than affective and psychiatric disorders, however, such as vital exhaustion (i.e. a feeling of unusual fatigue, demoralization, and increased irritability), have also been linked to risk of incident CAD. In a recent follow-up of 3714 men and 5168 women from the population-based Copenhagen City Heart Study that ranked the importance of both traditional and psychosocial risk factors with respect to their association with incident CAD, vital exhaustion was in men the highest ranking factor with a hazard ratio of 2.36 and the second highest ranking factor in women with a hazard ratio of 2.07 in adjusted analyses. Vital exhaustion also significantly improved the SCORE risk prediction model that is used by the European Society of Cardiology.

Can falls be predicted with gait analytical and posturographic measurement systems? A prospective follow-up study in a nursing home population

2012 ◽  
Vol 27 (2) ◽  
pp. 183-190 ◽  
Author(s):  
René Schwesig ◽  
David Fischer ◽  
Andreas Lauenroth ◽  
Stephan Becker ◽  
Siegfried Leuchte
Keyword(s):  
Risk Factors ◽  
Nursing Home ◽  
Predictive Value ◽  
Fall Risk ◽  
Inertial Sensor ◽  
Measurement Tool ◽  
Balance System ◽  
Follow Up Study ◽  
Increased Risk

Objective: To validate previously proposed findings and to develop an objective, feasible and efficient bifactorial (risk factors: gait impairment and balance disorders) fall risk assessment. Design: Prospective follow-up study Setting: Nursing homes (Halle/Saale, Germany). Subjects: One hundred and forty-six nursing home residents (aged 62–101 years) were recruited. Methods: Gait data were collected using a mobile inertial sensor-based system (RehaWatch). Postural regulation data were measured with the Interactive Balance System. Falls were recorded in standardized protocols over a follow-up period of 12 months. Main measures: Gait parameters (e.g. spatial-temporal parameters), posturographic parameters (e.g. postural subsystems), number of falls. Results: Seventeen (12%) of the participants had more than two falls per year. The predictive validity of the previously selected posturographic parameters was inadequate (sensitivity: 47%). The new measurement tool defined 67 participants showing an increased risk of falls. In reality, only 8 participants actually fell more than twice during the follow-up period (positive predictive value (PPV): 12%). The negative predictive value (NPV) was 88%. The posturographic frequency range F2–4 (peripheral–vestibular system), stride time and standard deviation of landing phase were the most powerful parameters for fall prediction. Gait and postural variability were larger in the high-risk group (e.g. gait speed; confidence interval (CI)high: 0.57–0.79 vs. CIlow: 0.72–0.81 m/s). Conclusion: RehaWatch and the Interactive Balance System are able to measure two of the most important fall risk factors, but their current predictive ability is not satisfactory yet. The correlation with physiological mechanisms is only shown by the Interactive Balance System.

P3624Prevalence and severity of coronary artery disease linked to prognosis in psoriasis patients referred for coronary computed tomography angiography: A multicentre cohort study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A B Tinggaard ◽  
K F Hjuler ◽  
I T Andersen ◽  
S Winther ◽  
L Iversen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Follow Up Study ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Artery Disease

Abstract Background Psoriasis (Pso) is a disease characterized by systemic inflammation and is associated with an increased risk of cardiovascular disease. However, the degree of coronary artery calcification in Pso and its relation to prognosis is largely unknown. Purpose The aim of this study was 1) to estimate the prevalence and severity of coronary artery disease (CAD) in this patient group and 2) to asses the risk of major adverse cardiovascular events (MACE) including revascularization and all-cause mortality after initial diagnosis and treatment in a large-scale cohort of patients who underwent coronary computed tomography angiography (CCTA) due to angina symptoms. Methods This study consists of two parts using data from the Western Denmark Heart Registry; a cross-sectional study included 40,125 patients and a follow-up study included 42,861 patients. Pso patients were identified by the National Patient Registry and verified by nationwide prescription and treatment code registers. Primary outcome in the cross-sectional study was a coronary artery calcium score (CACS) >0, with a secondary outcome defined as a CACS ≥400. In the follow-up study, the primary outcome was a combined outcome including myocardial infarction, revascularization, ischemic or unspecified stroke and all-cause mortality. Events within the first 90 days after CCTA were attributed to initial treatment and consequently excluded. All outcomes were adjusted for common cardiovascular risk factors and comorbidities. Results In the cross-sectional study 1,407 (3.5%) Pso patients were identified. OR was 1.31 (95% CI; 1.15–1.49) for CACS >0 and 1.33 (95% CI; 1.10–1.62) for CACS ≥400 in Pso patients compared to non-Pso patients. In the follow-up study 1,591 (3.7%) Pso patients were identified. The mean duration of follow-up after CCTA was 4.0 years (min/max 0.0/10.2). Crude HR for the combined outcome was 1.52 (95% CI; 1.24–1.87), while adjusted HR was 1.16 (95% CI; 0.95–1.43). Conclusion In this clinically relevant cohort of patients referred to CCTA for CAD rule out, coronary artery calcification was more frequent and more severe in Pso patients even compared to the control patients with several risk factors and angina symptoms, but without inflammatory diseases. An increased risk of the combined outcome of MACE including revascularization and all-cause mortality after initial treatment in Pso patients was found in the crude analysis. The increased risk seemed predominantly carried by an increase in traditional risk factors.

Causes of death, incidence and risk factors of cardiovascular diseases in Thai type 2 diabetic patients: a 5-year follow-up study

2003 ◽  
Vol 60 (3) ◽  
pp. 183-189 ◽  
Author(s):  
Rattana Leelawattana ◽  
Chatchalit Rattarasarn ◽  
Apiradee Lim ◽  
Supamai Soonthornpun ◽  
Worawong Setasuban
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Causes Of Death ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Follow Up Study ◽  
Type 2 Diabetic

scholarly journals β-cell dysfunction in women with previous gestational diabetes is associated with visceral adipose tissue distribution

2015 ◽  
Vol 173 (1) ◽  
pp. 63-70 ◽  
Author(s):  
Tove Lekva ◽  
Jens Bollerslev ◽  
Kristin Godang ◽  
Marie Cecilie Paasche Roland ◽  
Camilla Margrethe Friis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Visceral Fat ◽  
Cell Function ◽  
Post Partum ◽  
Β Cell ◽  
Follow Up Study ◽  
Increased Risk ◽  
Β Cell Function ◽  
In Pregnancy

ContextGlucose intolerance in pregnancy predicts an increased risk of future type 2 diabetes.ObjectiveThe aim of the study was to evaluate glucose metabolism in women with and without gestational diabetes mellitus (GDM) at 5 years follow-up and identify risk factors associated with disturbed glucose metabolism post-partum.DesignThis follow-up study included 300 consecutively enrolled women from a previous population-based cohort study. The participants underwent oral glucose tolerance test under pregnancy and in the follow-up study, in addition to dual-energy X-ray absorptiometry in the follow-up study.ResultsFifty-two women (17.7%) were found to have GDM in pregnancy with an odds ratio of 4.8 developing prediabetes 5 years later. β-cell function, but not insulin resistance or sensitivity, was reduced in the follow-up study after adjusting for known risk factors. Furthermore, visceral fat content at follow-up was increased in GDM women compared to non-GDM women, and the β-cell function declined with increasing visceral fat in both groups but was more pronounced in the women with previous GDM.ConclusionsWomen with GDM are at increased risk of developing prediabetes and have a decreased β-cell function 5 years post-partum that is associated with increased visceral fat mass.

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