scholarly journals Short-term increases of plasma cardiac troponin I are better evaluated by comparison with the reference change value

2010 ◽  
pp. 327-333 ◽  
Author(s):  
Giovanni Introcaso ◽  
Monica Raggi ◽  
Tiziana D'Errico ◽  
Annalisa Cavallero
Keyword(s):  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Short Term ◽  
Reference Change Value

Short-term biological variation and diurnal rhythm of cardiac troponin I (Access hs-TnI) in healthy subjects

2020 ◽  
Vol 504 ◽  
pp. 163-167 ◽  
Author(s):  
Martina Zaninotto ◽  
Andrea Padoan ◽  
Monica Maria Mion ◽  
Mariela Marinova ◽  
Mario Plebani
Keyword(s):  
Diurnal Rhythm ◽  
Cardiac Troponin ◽  
Healthy Subjects ◽  
Troponin I ◽  
Biological Variation ◽  
Cardiac Troponin I ◽  
Short Term

scholarly journals Biological variation of cardiac troponins in chronic kidney disease

2020 ◽  
Vol 57 (2) ◽  
pp. 162-169
Author(s):  
RA Jones ◽  
J Barratt ◽  
EA Brettell ◽  
P Cockwell ◽  
RN Dalton ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Troponin T ◽  
Biological Variation ◽  
Cardiac Troponin I ◽  
Cardiac Troponin T ◽  
Reference Change Value

Background Patients with chronic kidney disease often have increased plasma cardiac troponin concentration in the absence of myocardial infarction. Incidence of myocardial infarction is high in this population, and diagnosis, particularly of non ST-segment elevation myocardial infarction (NSTEMI), is challenging. Knowledge of biological variation aids understanding of serial cardiac troponin measurements and could improve interpretation in clinical practice. The National Academy of Clinical Biochemistry (NACB) recommended the use of a 20% reference change value in patients with kidney failure. The aim of this study was to calculate the biological variation of cardiac troponin I and cardiac troponin T in patients with moderate chronic kidney disease (glomerular filtration rate [GFR] 30–59 mL/min/1.73 m2). Methods and results Plasma samples were obtained from 20 patients (median GFR 43.0 mL/min/1.73 m2) once a week for four consecutive weeks. Cardiac troponin I (Abbott ARCHITECT® i2000SR, median 4.3 ng/L, upper 99th percentile of reference population 26.2 ng/L) and cardiac troponin T (Roche Cobas® e601, median 11.8 ng/L, upper 99th percentile of reference population 14 ng/L) were measured in duplicate using high-sensitivity assays. After outlier removal and log transformation, 18 patients’ data were subject to ANOVA, and within-subject (CVI), between-subject (CVG) and analytical (CVA) variation calculated. Variation for cardiac troponin I was 15.0%, 105.6%, 8.3%, respectively, and for cardiac troponin T 7.4%, 78.4%, 3.1%, respectively. Reference change values for increasing and decreasing troponin concentrations were +60%/–38% for cardiac troponin I and +25%/–20% for cardiac troponin T. Conclusions The observed reference change value for cardiac troponin T is broadly compatible with the NACB recommendation, but for cardiac troponin I, larger changes are required to define significant change. The incorporation of separate RCVs for cardiac troponin I and cardiac troponin T, and separate RCVs for rising and falling concentrations of cardiac troponin, should be considered when developing guidance for interpretation of sequential cardiac troponin measurements.

scholarly journals Cardiac Troponin I Predicts Short-Term Mortality in Vascular Surgery Patients

Circulation ◽  
2002 ◽  
Vol 106 (18) ◽  
pp. 2366-2371 ◽  
Author(s):  
Lauren J. Kim ◽  
Elizabeth A. Martinez ◽  
Nauder Faraday ◽  
Todd Dorman ◽  
Lee A. Fleisher ◽  
...  
Keyword(s):  
Vascular Surgery ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Short Term ◽  
Short Term Mortality

scholarly journals Clinical meaning and prognosis of the elevation degree of cardiac Troponin I in pericarditis of the adult: short-term and mid-term follow-up results

Critical Care ◽  
2007 ◽  
Vol 11 (Suppl 2) ◽  
pp. P243 ◽  
Author(s):  
E Abu Assi ◽  
C Peña Gil ◽  
R Vidal Perez ◽  
J Garcia Acuña ◽  
A Amaro Cendon
Keyword(s):  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Short Term ◽  
Clinical Meaning

scholarly journals Prognostic Value of Serial Changes in High-Sensitivity Cardiac Troponin I and T over 3 Months Using Reference Change Values in Hemodialysis Patients

2016 ◽  
Vol 62 (4) ◽  
pp. 631-638 ◽  
Author(s):  
Yader Sandoval ◽  
Charles A Herzog ◽  
Sara A Love ◽  
Jing Cao ◽  
Yan Hu ◽  
...  
Keyword(s):  
Cardiac Troponin ◽  
Prognostic Value ◽  
Troponin I ◽  
High Sensitivity ◽  
Cardiac Troponin I ◽  
Adverse Outcomes ◽  
Cox Models ◽  
Reference Change Value ◽  
Hazard Ratios ◽  
All Cause Mortality

Abstract INTRODUCTION Serial changes in cardiac troponin in hemodialysis (HD) patients have uncertain clinical implications. We evaluated associations of adverse outcomes in HD patients with reference change value (RCV) data and tertile concentrations for cardiac troponin I (cTnI) and cTnT measured by high-sensitivity (hs) assays. METHODS RCV data and tertiles for hs-cTnI and hs-cTnT were determined from plasma samples collected 3 months apart in 677 stable outpatient HD patients and assessed for their associations with adverse outcomes using adjusted Cox models. Primary outcomes were all-cause mortality and sudden cardiac death (SCD). RESULTS During a median follow-up of 23 months, 18.6% of patients died. RCVs were: hs-cTnI +37% and −30%; hs-cTnT +25% and −20%. Patients with serial hs-cTnI and hs-cTnT changes >RCV (increase or decrease) had all-cause mortality of 25.2% and 23.8% respectively, compared to 15.0% and 16.5% with changes ≤RCV [adjusted hazard ratios (aHRs): 1.9, P = 0.0003 and 1.7, P = 0.0066), respectively]. Only hs-cTnI changes >RCV were predictive of SCD (aHR 2.6, P = 0.005). hs–Cardiac troponin changes >RCV improved all-cause mortality prognostication compared to changes ≤RCV in tertile 2: hs-cTnI aHR, 2.70 (P = 0.003); hs-cTnT aHR, 1.98 (P = 0.043). The aHR of changes in hs-cTnI in tertile 2 >RCV for SCD was 5.62 (P = 0.039). CONCLUSIONS Changes over 3 months in hs-cTnI and hs-cTnT of >RCV identified patients at greater risk of all-cause mortality, and for hs-cTnI were also predictive of SCD. Among patients with middle tertile cardiac troponin concentrations, hs-cTnI changes >RCV provided additive prognostic value for both SCD and all-cause mortality, whereas those for hs-cTnT provided additive prognostic value only for all-cause mortality.

Cord Blood Cardiac Troponin I as an Early Predictor of Short-Term Outcome in Perinatal Hypoxia

Neonatology ◽  
2004 ◽  
Vol 86 (2) ◽  
pp. 131-137 ◽  
Author(s):  
Gülcan Türker ◽  
Kadir Babaoğlu ◽  
Ayşe S. Gökalp ◽  
Nazan Sarper ◽  
Emine Zengin ◽  
...  
Keyword(s):  
Cord Blood ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Perinatal Hypoxia ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome ◽  
Early Predictor

scholarly journals Short term physical exercise leads to a small troponin increase measurable with a high-sensitive cardiac troponin I assay

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P4008-P4008
Author(s):  
T. Reichlin ◽  
S. M. Sou ◽  
T. H. Hochgruber ◽  
E. Vogler ◽  
K. Roost ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Short Term
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